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Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation

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Abstract

Cardamonin is a chalconoid isolated from various herbs, such as Alpinia katsumadai and Carya cathayensis Sarg. This study examined the effect of cardamonin on angiotensin II (Ang II)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs) as well as its underlying mechanisms. The results showed that cardamonin significantly inhibited Ang II-induced proliferation and migration in rat VSMCs in a concentration-dependent manner. Moreover, cardamonin suppressed Ang II-induced phosphorylation of p38 MAPK, Akt, and extracellular regulated protein kinase (ERK). These findings indicate that the downregulation of p38 MAPK, Akt, and ERK phosphorylation might be, at least in part, involved in cardamonin-suppressed proliferation and migration induced by Ang II in rat VSMCs. As proliferation and migration of VSMCs play critical roles in the pathogenesis of atherosclerosis, cardamonin might be a potential candidate for atherosclerosis treatment.

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Acknowledgments

This study was supported by the National Science Foundation of China (No. 81303258) and the Medical Scientific Research of Zhejiang Province (2012KYB136). We greatly thank Mr. Fu-Sheng Jiang and Dr. Jian-Li Gao from Zhejiang Chinese Medical University for the technical advice.

Conflict of interest

The authors declare that no actual or potential conflict of interest exists in relation to this article.

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Authors and Affiliations

  1. College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China

    Yan-Jing Shen, Xue-Xin Zhu, Xian Yang, Bo Jin, Bin Ding & Zhi-Shan Ding

  2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

    Jin-Jian Lu

  3. Institute of Chinese Medicine, Wenzhou Medical University, Ouhai District, Wenzhou, China

    Su-Hong Chen

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  1. Yan-Jing Shen
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Correspondence to Su-Hong Chen.

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Shen, YJ., Zhu, XX., Yang, X. et al. Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation. J Nat Med 68, 623–629 (2014). https://doi.org/10.1007/s11418-014-0825-0

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  • DOI: https://doi.org/10.1007/s11418-014-0825-0

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