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Haworforbins A–C, new phenolics from Haworthia cymbiformis

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Abstract

Two new isocoumarin glucosides, haworforbins A (1) and B (2), and a new chromone, haworforbin C (3), have been isolated from Haworthia cymbiformis. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Haworforbin C (3) exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cell line.

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Fig. 1
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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and a grant from The Open Research Center Project in Hoshi University.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan

    Fumie Yamasaki, Shoko Machida, Asami Nakata, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda & Hiroshi Morita

  2. Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa, 769-2193, Japan

    Osamu Shirota

  3. Sabotensoudanshitsu, 4-23 Chiyoda-cho, Tatebayashi, Gunma, 374-0028, Japan

    Naoyuki Hagane & Tadayoshi Sugizaki

Authors
  1. Fumie Yamasaki
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  2. Shoko Machida
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  3. Asami Nakata
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  4. Alfarius Eko Nugroho
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  5. Yusuke Hirasawa
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  6. Toshio Kaneda
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  7. Osamu Shirota
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  8. Naoyuki Hagane
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  9. Tadayoshi Sugizaki
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  10. Hiroshi Morita
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Corresponding author

Correspondence to Hiroshi Morita.

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Yamasaki, F., Machida, S., Nakata, A. et al. Haworforbins A–C, new phenolics from Haworthia cymbiformis . J Nat Med 67, 212–216 (2013). https://doi.org/10.1007/s11418-012-0647-x

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  • DOI: https://doi.org/10.1007/s11418-012-0647-x

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