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Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats

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Abstract

The effect of Eriobotrya japonica seed extract (ESE) prepared with 70% ethanol on gastric mucosal injury was investigated. Six experimental models with different action mechanisms were used for the evaluation. Three concentrations of ESE were prepared for each model. ESE administration was initiated 14 days before induction of gastric mucosal injury, and its effect was investigated. ESE inhibited formation of gastric mucosal injury.

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Authors and Affiliations

  1. Japan Science and Technology Agency, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Junko Yokota

  2. Department of Biomedical Science, Kochi Medical Graduate School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Daisuke Takuma, Masahide Onogawa & Yutaka Nishioka

  3. Department of Pharmacy, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Atsuhide Hamada, Masahide Onogawa, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani & Yutaka Nishioka

Authors
  1. Junko Yokota
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  2. Daisuke Takuma
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  3. Atsuhide Hamada
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  4. Masahide Onogawa
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  5. Saburo Yoshioka
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  6. Masahiko Kusunose
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  7. Mitsuhiko Miyamura
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  8. Shojiro Kyotani
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  9. Yutaka Nishioka
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Correspondence to Junko Yokota.

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Yokota, J., Takuma, D., Hamada, A. et al. Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats. J Nat Med 62, 96–100 (2008). https://doi.org/10.1007/s11418-007-0195-y

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  • DOI: https://doi.org/10.1007/s11418-007-0195-y

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