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An expanding GSK3 network: implications for aging research

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Abstract

The last few decades of longevity research have been very exciting. We now know that longevity and healthspan can be manipulated across species, from unicellular eukaryotes to nonhuman primates, and that while aging itself is inevitable, how we age is malleable. Numerous dietary, genetic, and pharmacological studies now point to links between metabolism and growth regulation as a central aspect in determining longevity and, perhaps more importantly, health with advancing age. Here, we focus on a relatively new player in aging studies GSK3, glycogen synthase kinase, a key factor in growth and metabolism whose name fails to convey the extensive breadth of its role in cellular adaptation. First, we provide a brief overview of GSK3, touching on those aspects that are likely relevant to aging. Then, we outline the role of GSK3 in cellular functions including growth signaling, cell fate, and metabolism. Next, we describe evidence demonstrating a direct role for GSK3 in a range of age-related diseases, despite the fact that they differ considerably in their etiology and pathology. Finally, we discuss the role that GSK3 may play in normative aging and how GSK3 might be a suitable target to oppose age-related disease vulnerability.

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Acknowledgments

The study was conducted with the use of resources and facilities at the William S. Middleton Memorial Veterans Hospital, Madison WI. The authors declare no conflict of interest.

Funding

This work was supported by NIH AG057408, The Glenn Foundation for Medical Research, the American Federation for Aging Research, and NIH training fellowship AG000213 (DSC).

Author information

Authors and Affiliations

  1. Division of Geriatrics, Department of Medicine, SMPH, University of Wisconsin, Madison, WI, 53705, USA

    Dylan C. Souder & Rozalyn M. Anderson

  2. Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI, 53705, USA

    Rozalyn M. Anderson

Authors
  1. Dylan C. Souder
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  2. Rozalyn M. Anderson
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Correspondence to Rozalyn M. Anderson.

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Souder, D.C., Anderson, R.M. An expanding GSK3 network: implications for aging research. GeroScience 41, 369–382 (2019). https://doi.org/10.1007/s11357-019-00085-z

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  • DOI: https://doi.org/10.1007/s11357-019-00085-z

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