Abstract
This study is to investigate the association between nickel exposure and serum lipid profiles. We analyzed the population from the National Health and Nutrition Examination Surveys (NHANES) 2017–2018. Urinary nickel exposure was measured using inductively coupled-plasma mass spectrometry. Serum lipid profiles, including triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C), were measured using the standard biochemistry assays. The association between urinary nickel and lipid profiles was examined using multivariable linear regression models and restricted cubic spine plots. There was a significant negative relationship between nickel level and TC (β, − 9.67; 95% CI, − 13.58 to − 5.76), HDL-C (β, − 1.57; 95% CI, − 2.98 to − 0.16), and LDL-C (β, − 5.88; 95% CI, − 11.04 to − 0.71) after adjusting for potential confounding factors. Furthermore, restricted cubic spines showed that only HDL-C was nonlinearly associated with nickel (p for nonlinearity 0.004). However, nickel exposure was not related to the level of triglyceride. The exposure to nickel was linearly associated with serum total cholesterol and LDL-C while nonlinearly associated with HDL-C in general population.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data Availability
The datasets were available from NHANES 2017–2018 (https://www.cdc.gov/nchs/nhanes/index.htm).
References
Angerer J, Ewers U, Wilhelm M (2007) Human biomonitoring: state of the art. Int J Hyg Environ Health 210:201–228
Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH (2009) Heavy metals, islet function and diabetes development. Islets 1:169–176
Das Gupta A, Das SN, Dhundasi SA, Das KK (2008) Effect of garlic (Allium sativum) on heavy metal (nickel II and chromium VI) induced alteration of serum lipid profile in male albino rats. Int J Environ Res Public Health 5:147–151
Das KK, Gupta AD, Dhundasi SA, Patil AM, Das SN, Ambekar JG (2006) Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology in rats. J Basic Clin Physiol Pharmacol 17:29–44
Das S, Reddy RC, Chadchan KS, Patil AJ, Biradar MS, Das KK (2020) Nickel and oxidative stress: cell signaling mechanisms and protective role of vitamin C. Endocr Metab Immune Disord Drug Targets 20:1024–1031
Fu Z, Xi S (2020) The effects of heavy metals on human metabolism. Toxicol Mech Methods 30:167–176
Guo H, Chen L, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wang X, Wu B (2015): Research advances on pathways of nickel-induced apoptosis. Int. J. Mol. Sci. 17
Jiang Q, Xiao Y, Long P, Li W, Yu Y, Liu Y, Liu K, Zhou L, Wang H, Yang H, Li X, He M, Wu T, Yuan Y (2021) Associations of plasma metal concentrations with incident dyslipidemia: prospective findings from the Dongfeng-Tongji cohort. Chemosphere 285:131497
Kang P, Shin HY, Kim KY (2021): Association between dyslipidemia and mercury exposure in adults. Int. J. Environ. Res. Public Health 18
Liu A, Xu P, Gong C, Zhu Y, Zhang H, Nie W, Zhou X, Liang X, Xu Y, Huang C, Liu XL, Zhou JC (2020) High serum concentration of selenium, but not calcium, cobalt, copper, iron, and magnesium, increased the risk of both hyperglycemia and dyslipidemia in adults: a health examination center based cross-sectional study. J Trace Elem Med Biol 59:126470
Liu G, Sun L, Pan A, Zhu M, Li Z, ZhenzhenWang Z, Liu X, Ye X, Li H, Zheng H, Ong CN, Yin H, Lin X, Chen Y (2015) Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults. Int J Epidemiol 44:240–248
Liu Y, Wu M, Xu B, Kang L (2021) Association between the urinary nickel and the diastolic blood pressure in general population. Chemosphere 286:131900
Mania M, Rebeniak M, Postupolski J (2019) Food as a source of exposure to nickel. Rocz Panstw Zakl Hig 70:393–399
Morsy GM, El-Ala KS, Ali AA (2016) Studies on fate and toxicity of nanoalumina in male albino rats: lethality, bioaccumulation and genotoxicity. Toxicol Ind Health 32:344–359
Ohashi F, Fukui Y, Takada S, Moriguchi J, Ezaki T, Ikeda M (2006) Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan. Int Arch Occup Environ Health 80:117–126
Stangl GI, Kirchgessner M (1996) Nickel deficiency alters liver lipid metabolism in rats. J Nutr 126:2466–2473
Tobert JA, Newman CB (2016) Management of dyslipidemia for cardiovascular disease risk reduction. Ann Intern Med 164:509
Tsang ACO, Nicholson P, Pereira VM (2018) Nickel-related adverse reactions in the treatment of cerebral aneurysms: a literature review. World Neurosurg 115:147–153
Xiao L, Zhou Y, Ma J, Cao L, Wang B, Zhu C, Yang S, Li W, Zhang Z, Wang D, Guo Y, Mu G, Yuan J, Chen W (2019) The cross-sectional and longitudinal associations of chromium with dyslipidemia: a prospective cohort study of urban adults in China. Chemosphere 215:362–369
Xu H, Mao Y, Xu B, Hu Y (2021) Low-level environmental lead and cadmium exposures and dyslipidemia in adults: findings from the NHANES 2005–2016. J Trace Elem Med Biol 63:126651
Zhang Z, Chau PY, Lai HK, Wong CM (2009) A review of effects of particulate matter-associated nickel and vanadium species on cardiovascular and respiratory systems. Int J Environ Health Res 19:175–185
Zhou Z, Lu YH, Pi HF, Gao P, Li M, Zhang L, Pei LP, Mei X, Liu L, Zhao Q, Qin QZ, Chen Y, Jiang YM, Zhang ZH, Yu ZP (2016) Cadmium exposure is associated with the prevalence of dyslipidemia. Cell Physiol Biochem 40:633–643
Zhu X, Fan Y, Sheng J, Gu L, Tao Q, Huang R, Liu K, Yang L, Chen G, Cao H, Li K, Tao F, Wang S (2021) Association between blood heavy metal concentrations and dyslipidemia in the elderly. Biol Trace Elem Res 199:1280–1290
Author information
Authors and Affiliations
Contributions
Y XH designed the study; C ZW and H J performed statistical analysis; C LH and W XH wrote the manuscript.
Corresponding author
Ethics declarations
Ethics approval
The study protocol was approved by NCHS Research Ethics Review Board.
Consent to participate
The author consented to participate in this research study.
Consent for publication
The author consents to publish the current research in the Environmental Science and Pollution Research journal.
Conflict of interest
The author declares no competing interests.
Additional information
Responsible Editor: Lotfi Aleya
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Chen, Z., He, J., Chen, L. et al. Association between the nickel exposure and lipid profiles in general population from NHANES. Environ Sci Pollut Res 29, 66383–66388 (2022). https://doi.org/10.1007/s11356-022-20509-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-022-20509-2