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Association of heat shock protein70-2 genotypes with hypertension among textile workers occupationally exposed to noise

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Abstract

Noise exposure is a primary cause of hearing loss with a broad range of auditory and non-auditory effects. It is one of the occupational health risks in both developed and industrialized countries. Heat shock proteins (HSPs) are induced after severe noise exposure. Those proteins protect the ear from damage following excessive noise exposure. This protection showed high variability between individuals. The aim of the study was to investigate the variation in hearing loss and blood pressure in textile workers and its association with genetic predisposition related to HSP70 genes. Also, the role of smoking was studied. We genotyped HSP-70 (hsp70-1, hsp70-2, and hsp70-hom) genes in 109 textile workers working in a noisy environment. Diastolic and systolic blood pressure was measured for workers. Hearing was assessed using an audiogram. We reported significant variation in HSP70-homo genotypes among smoker workers and nonsmoker ones. Only HSP70-2 genotypes were associated with high significant variations in both systolic and diastolic blood pressure among textile workers. Positive correlation between duration of exposure and both systolic (P < 0.047) and diastolic blood pressure (P < 0.033) was observed among workers. Our study recorded that HSP70-2 genotypes were associated with hypertension among textile workers with absence of that association with either HSP70-1 or HSP70-homo genotypes. We also confirmed the relationship between noise exposure and blood pressure (both systolic and diastolic blood pressure). Furthermore, significant variation was shown in HSP70-hom genotypes among smoker and nonsmoker workers.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Acknowledgements

The authors express their sincere thanks to Prof. Dr. Eman ElTahlawy, Prof. of Environmental and Preventive Medicine, National Research Centre, for her encouragement during the study and her help in analyzing the data.

Funding

The study was funded by the National Research Centre. The grant number is 11010180.

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Authors and Affiliations

  1. Department of Environmental and Occupational Medicine, Environmental Research Division, National Research Centre, Giza, Dokki, Egypt

    Mona Mohamed Taha, Nagat Mohamed Amer, Safia Beshir & Heba Mahdy-abdallah

Authors
  1. Mona Mohamed Taha
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  2. Nagat Mohamed Amer
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  3. Safia Beshir
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  4. Heba Mahdy-abdallah
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Contributions

MMT designed the study and performed genetic analysis and wrote the manuscript; NMA performed clinical examination. HMA interviewed the participants and performed audiometric analysis. SB interpreted the data. All authors have critically reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.

Corresponding author

Correspondence to Mona Mohamed Taha.

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Ethics approval and consent to participate

Consents were obtained from all subjects before onset of work. Approval of the ethical committee of the National Research Centre was taken prior to the study (Registration number 11010180).

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The corresponding author took the consent of all co-authors before sending the paper for publication.

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The authors declare no competing interests.

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Responsible Editor: Lotfi Aleya

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Taha, M.M., Amer, N.M., Beshir, S. et al. Association of heat shock protein70-2 genotypes with hypertension among textile workers occupationally exposed to noise. Environ Sci Pollut Res 29, 13998–14004 (2022). https://doi.org/10.1007/s11356-021-16802-1

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  • DOI: https://doi.org/10.1007/s11356-021-16802-1

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