Abstract
Among residents living close to agricultural fields who are potentially exposed to pesticides, pregnant women and their fetuses are of particular concern for their vulnerability to environmental chemicals. In this collaborative multicenter study, we covered a wide distribution of participants in the most important fruit production zone of north Patagonia (Argentina) to investigate whether maternal residential proximity to fruit croplands with intense pesticide applications (rural group –RG-) is associated with pregnancy complications and alterations in their newborn parameters compared to the urban population (urban group –UG-). A total of 776 pregnant women met the inclusion criteria. The percentage of threatened miscarriage was significantly higher in the RG than in the UG. The percentage of miscarriage, threat of premature labor, intrauterine fetal death, preterm premature rupture of membranes, and intrauterine growth retardation were similar in both groups. Newborn anthropometric parameters were corrected by sex and gestational age prior to statistical analysis. Length at birth and head circumference were lower in the RG than in the UG. Birth weight was similar in both groups. The percentage of head circumference less than the 5th percentile and the ponderal index were greater in the RG than in the UG. Our results suggest that proximity to pesticide applications may increase the risk of pregnancy complications and altered newborn parameters.
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Data availability
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- BW:
-
Birth weight
- CBMs:
-
Carbamates
- HC:
-
Head circumference
- LB:
-
Length at birth
- NNTs:
-
Neonicotinoids
- OPs:
-
Organophosphates
- PI:
-
Ponderal index at birth
- RG:
-
Rural group
- UG:
-
Urban group
References
Arbuckle TE, Lin Z, Mery LS (2001) An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environ Health Perspect 109:851–857. https://doi.org/10.1289/ehp.01109851
Babina K, Dollard M, Pilotto L, Edwards JW (2012) Environmental exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children: a cross sectional study. Environ Int 48:109–120. https://doi.org/10.1016/j.envint.2012.07.007
Bell EM, Hertz-Picciotto I, Beaumont JJ (2001) Case-cohort analysis of agricultural pesticide applications near maternal residence and selected causes of fetal death. Am J Epidemiol 154:702–710. https://doi.org/10.1093/aje/154.8.702
Béranger R, Hardy EM, Binter AC, Charles MA, Cécile Zaros C, Appenzeller BMR, Chevrier C (2020) Multiple pesticides in mothers’ hair samples and children’s measurements at birth: results from the French national birth cohort (ELFE). Int J Hyg Environ Health 223:22–33. https://doi.org/10.1016/j.ijheh.2019.10.010
Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, Holzman IR, Wolff MS (2004) In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect 112:388–391. https://doi.org/10.1289/ehp.6414
Blanco-Muñoz J, Aguilar-Garduño C, Gamboa-Avila R, Rodríguez-Barranco M, Pérez-Méndez O, Huesca-Gómez C, González-Alzaga B, Lacasaña M (2013) Association between PON1 genetic polymorphisms and miscarriage in Mexican women exposed to pesticides. Sci Total Environ 449:302–308. https://doi.org/10.1016/j.scitotenv.2013.01.034
Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, Trujillo C, Johnson C, Bradman A, Barr DB, Eskenazi B (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect 119(8):1189–1195. https://doi.org/10.1289/ehp.1003185
Bradman A, Castorina R, Barr DB, Chevrier J, Harnly ME, Eisen EA, McKone TE, Harley K, Holland N, Eskenazi B (2011) Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community. Int. J. Environ. Res. Public Health 8:1061–1083. https://doi.org/10.3390/ijerph8041061
Bradman A, Kogut K, Eisen EA, Jewell NP, Quirós-Alcalá L, Castorina R, Chevrier J, Holland NT, Barr DB, Kavanagh-Baird G, Eskenazi B (2013) Variability of organophosphorous pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week. Environ Health Perspect 121(1):118–124. https://doi.org/10.1289/ehp.1104808
Buchmayer SM, Sparén P, Cnattingius S (2004) Previous pregnancy loss: risks related to severity of preterm delivery. Am J Obstet Gynecol 191(4):1225–1231. https://doi.org/10.1016/j.ajog.2004.02.066
Bukasala JS, Brunekreef B, Brouwer M, Koppelman GH, Wijga AH, Huss A, Gehring U (2018) Associations of residential exposure to agricultural pesticides with asthma prevalence in adolescence: the PIAMA birth cohort. Environ Int 121:435–442. https://doi.org/10.1016/j.envint.2018.09.029
Bulgaroni V, Rovedatti MG, Sabino G, Magnarelli G (2012) Organophosphate pesticide environmental exposure: analysis of salivary cholinesterase and carboxilesterase activities in preschool children and their mothers. Environ Monit Assess 184(5):3307–3314. https://doi.org/10.1007/s10661-011-2190-8
Bulgaroni V, Lombardo P, Rivero-Osimani V, Vera B, Dulgerian L, Cerbán F, Guiñazú N (2013) Environmental pesticide exposure modulates cytokines, arginase and ornithine decarboxylase expression in human placenta. Reprod Toxicol 39:23–32. https://doi.org/10.1016/j.reprotox.2013.03.010
Carmichael SL, Yang W, Roberts E, Kegley SE, Padula AM, English PB, Lammer EJ, Shaw GM (2014) Residential agricultural pesticide exposures and risk of selected congenital heart defects among offspring in the San Joaquin Valley of California. Environ Res 135:133–138. https://doi.org/10.1016/j.envres.2014.08.030
Cecchi A, Rovedatti MG, Sabino G, Magnarelli GG (2012) Environmental exposure to organophosphate pesticides: assessment of endocrine disruption and hepatotoxicity in pregnant women. Ecotox Environ Safe 80:280–287. https://doi.org/10.1016/j.ecoenv.2012.03.008
Cheikh Ismail L, Knight HE, Bhutta Z, Chumlea WC, International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) (2013) Anthropometric protocols for the construction of new international fetal and newborn growth standards: the INTERGROWTH-21st Project. BJOG 120(2):42–47. https://doi.org/10.1111/1471-0528.12125
Chiapella G, Genti-Raimondi S, Magnarelli G (2014) Placental oxidative status in rural residents environmentally exposed to organophosphates. Environ Toxicol Pharmacol 38:220–229. https://doi.org/10.1016/j.etap.2014.06.001
Copes WJ (2012) Evaluation of plant barriers to mitigate spray drift. Thesis, Master of Environmental Engineering, Faculty of Engeneering, National University of Comahue [in Spanish]. https://inta.gob.ar/documentos/evaluacion-de-barreras-vegetales-para-mitigar-la-deriva-de-pulverizaciones
Coronado GD, Vigoren EM, Thompson B, Griffith WC, Faustman EM (2006) Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway. Environ Health Perspect 114(7):999–1006. https://doi.org/10.1289/ehp.8620
Davari-Tanha F, Shariat M, Kaveh M, Ebrahimi M, Jalalvand S (2008) Threatened abortion: a risk factor for poor pregnancy outcome. Acta Med Iran 46(4):314–320. https://doi.org/10.1016/j.ajog.2003.09.023
Deziel NC, Freeman LE, Graubard BI, Jones RR, Hoppin JA, Thomas K, Hines CJ, Blair A, Sandler DP, Chen H, Lubin JH, Andreotti G, Alavanja MCR, Friesen MC (2017) Relative contributions of agricultural drift, para-occupational, and residential use exposure pathways to house dust pesticide concentrations: meta-regression of published data. Environ Health Perspect 125:296–305. https://doi.org/10.1289/EHP426
Ervalahti N, Korkman M, Fagerlund A, Autti-Rämö I, Loimu L, Hoyme HE (2007) Relationship between dysmorphic features and general cognitive function in children with fetal alcohol spectrum disorders. Am J Med Genet 43:2916–2923. https://doi.org/10.1002/ajmg.a.32009
Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell N, Barr D, Furlong C, Holland N (2004) Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect 112(10):1116–1124. https://doi.org/10.1289/ehp.6789
Fayyaz J (2005) Ponderal index. J Pak Med Assoc 55(6):228–229 https://ecommons.aku.edu/pakistan_fhs_mc_emerg_med/196
Fenik J, Tankiewicz M, Biziuk M (2011) Properties and determination of pesticides in fruits and vegetables. Trends Anal Chem 30(6):814–826. https://doi.org/10.1016/j.trac.2011.02.008
Fenske RA, Lu C, Curl CL, Shirai JH, Kissel JC (2005) Biologic monitoring to characterize organophosphorus pesticide exposure among children and workers: an analysis of recent studies in Washington State. Environ Health Perspect 113:1651–1657. https://doi.org/10.1289/ehp.8022
Friedman E, Hazlehurst MF, Loftus C, Karr C, McDonald KN, Suarez-Lopez JR (2020) Residential proximity to greenhouse agriculture and neurobehavioral performance in Ecuadorian children. Int J Hyg Environ Health 223:220–227. https://doi.org/10.1016/j.ijheh.2019.08.009
FunBaPa (2010) Evaluation of the impact of the National Program of Suppression of Carpocapsa on the pome fruit growing in the irrigated valleys of Norpatagonia. FunBaPa Eds., Viedma, 79pp [in Spanish]. http://www.funbapa.org.ar/funbapa/wp-content/uploads/2013/06/impacto-carpocapsa.pdf last. january 2020
García J, Ventura MI, Requena M, Hernández AF, Parrón T, Alarcón R (2017) Association of reproductive disorders and male congenital anomalies with environmental exposure to endocrine active pesticides. Reprod Toxicol 71:95–100. https://doi.org/10.1016/j.reprotox.2017.04.011
Gunier RB, Bradman A, Harley KG, Kogut K, Eskenazi B (2017) Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children. Environ Health Perspect 125(5):057002. https://doi.org/10.1289/EHP504
Hanke W, Jurewicz J (2004) The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence. Int J Occup Med Environ Health 17(2):223–243
Harley K, Huen K, Aguilar-Schall R, Holland N, Bradman A, Barr DB, Eskenazi B (2011) Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PLoS One 6(8):e23923. https://doi.org/10.1371/journal.pone.0023923
Harris SM, Jin Y, Loch-Caruso R, Padilla IY, Meeker JD, Bakulski KM (2020) Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database. Environ Res 184:109259. https://doi.org/10.1016/j.envres.2020.109259
Jaacks LM, Diao N, Calafat AM, Ospina M, Mazumdar M, Hasan M, Wright R, Quazi Quamruzzaman Q, Christiani DC (2019) Association of prenatal pesticide exposures with adverse pregnancy outcomes and stunting in rural Bangladesh. Environ Int 133:105243. https://doi.org/10.1016/j.envint.2019.105243
Jamal A, Moshfeghi M, Moshfeghi S, Mohammadi N, Zarean E, Jahangiri N (2017) Is preterm placental calcification related to adverse maternal and foetal outcome? J Obstet Gynaecol 37(5):605–609. https://doi.org/10.1080/01443615.2017.1285871
Janssen PA, Thiessen P, Klein MC, Whitfield MF, MacNab YC, Cullis-Kuhl SC (2007) Standards for the measurement of birth weight, length and head circumference at term in neonates of European, Chinese and South Asian ancestry. Open Med 1(2):e74–e88
Kirs VE (2002) Dynamic and Degradation of Organophosphate Pesticides in High Valley of Negro River Soil. Thesis, Master of Chemical Sciences, Faculty of Engeneering, National University of Comahue [in spanish]. http://opac.uncoma.edu.ar/cgi-bin/koha/opac-detail.pl?biblionumber=81
Koureas M, Tsakalof A, Tsatsakis A, Hadjichristodoulou C (2012) Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol Lett 210:155–168. https://doi.org/10.1016/j.toxlet.2011.10.007
Lejarraga H, Fustiñana C (1986) Weight, body length, and head circumference standards from 26 to 92 weeks of postmenstrual age. Arch Argent Pediatr 84:210–214 [in Spanish]. https://www.sap.org.ar/docs/publicaciones/archivosarg/1986/1986_84_4.pdf
Levario-Carrillo M, Olave ME, Corral D, Alderete JG, Gagioti S, Bevilacqua E (2004) Placental morphology of rats prenatally exposed to methyl parathion. Exp Toxicol Pathol 55(6):489–496. https://doi.org/10.1078/0940-2993-00346
Lindley A, Benson J, Grimes C, Cole T, Herman A (1999) The relationship in neonates between clinically measured head circumference and brain volume estimated from head CT-scans. Early Hum Dev 56(1):17–29. https://doi.org/10.1016/S0378-3782(99)00033-X
Ling C, Liew Z, von Ehrenstein OS, Heck JE, Park AS, Cui X, Cockburn M, Wu J, Ritz B (2018) Prenatal exposure to ambient pesticides and preterm birth and term low birthweight in agricultural regions of California. Toxics 6(3):E41. https://doi.org/10.3390/toxics6030041
Loewy RM, Monza LB, Kirs VE, Savini MC (2011) Pesticide distribution in an agricultural environment in Argentina. J Environ Sci Health A 46:662–670. https://doi.org/10.1080/03601234.2012.592051
Longnecker MP, Klebanoff MA, Dunson DB, Guo X, Chen Z, Zhou H, Brock JW (2005) Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies. Environ Res 97(2):127–133. https://doi.org/10.1016/S0013-9351(03)00108-7
Lu C, Fenske RA, Simcox NJ, Kalman D (2000) Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environ Res 84(3):290–302. https://doi.org/10.1006/enrs.2000.4076
Macchi P, Loewy RM, Lares B, Latini L, Monza L, Guiñazú N, Montagna CM (2018) The impact of pesticides on the macroinvertebrate community in the water channels of the Río Negro and Neuquén Valley, North Patagonia (Argentina). Environ Sci Pollut Res Int 25:1066–10678. https://doi.org/10.1007/s11356-018-1330-x
Magnarelli GG, Rovedatti MG, Pechen de D’Angelo AM (2011) Pesticides and human health. In: Anguiano OL, Montagna CM (eds) Pesticide classification and toxicology. EDUCO, Neuquén, pp 309–340 [in Spanish]. http://www.ctys.com.ar/index.php?idPage=20&idArticulo=1826
Mahibbur RM, Govindarajulu Z (1997) A modification of the test of Shapiro and Wilks for normality. J Appl Stat 24(2):219–235. https://doi.org/10.1080/02664769723828
Mardones F, Rosso P (1997) Design of a weight gain chart for pregnant women. Rev Méd Chile 125:1437–1448
Matthews G, Hamey P (2003) Exposure of bystanders to pesticides. Pestic Outlook 14:210–212. https://doi.org/10.1039/b311469b
Ministry of Public Finance, Presidency of Argentine (2016) Value chain analysis report. Fresh fruits - apples and pears [in Spanish]. https://www.economia.gob.ar/peconomica/docs/Complejo_fruta_pepita.pdf. Accessed 1 Apri 2020
Muñoz Quezada MT, Lucero B, Bradman A, Steenland K, Zúñiga L, Calafat AM, Ospina M, Iglesias V, Muñoz MP, Buralli RJ, Fredes C, Gutiérrez JP (2019) An educational intervention on the risk perception of pesticides exposure and organophosphate metabolites urinary concentrations in rural school children in Maule Region. Chile Environ Res 176:108554. https://doi.org/10.1016/j.envres.2019.108554
Mwila K, Burton MH, Van Dyk JS, Pletschke BI (2013) The effect of mixtures of organophosphate and carbamate pesticides on acetylcholinesterase and application of chemometrics to identify pesticides in mixtures. Environ Monit Assess 185(3):2315–2327. https://doi.org/10.1007/s10661-012-2711-0
Ortega-García JA, Gutierrez-Churango JE, Sánchez-Sauco MF, Martínez-Aroca M, Delgado-Marín JL, Sánchez-Solis M, Parrilla-Paricio JJ, Claudio L, Martínez-Lage JF (2012) Head circumference at birth and exposure to tobacco, alcohol and illegal drugs during early pregnancy. Childs Nerv Syst 28(3):433–439. https://doi.org/10.1007/s00381-011-1607-6
Park C, Kang M-Y, Kim D, Park J, Eom H, Kim E-A (2017) Prevalence of abortion and adverse pregnancy outcomes among working women in Korea: a cross-sectional study. PLoS One 12(8):e0182341. https://doi.org/10.1371/journal.pone.0182341
Parvez S, Gerona RR, Proctor C, Friesen M, Ashby JL, Reiter JL, Lui Z, Winchester PD (2018) Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study. Environ Health 17:23. https://doi.org/10.1186/s12940-018-0367-0
Pastore LM, Hertz-Picciotto I, Beaumont JJ (1997) Risk of stillbirth from occupational and residential exposures. Occup Environ Med 54:511–518. https://doi.org/10.1136/oem.54.7.511
Perera FP, Rauh V, Tsai WY, Kinney P, Camann D, Barr D, Bernert T, Garfinkel R, Tu YH, Diaz D, Dietrich J, Whyatt RM (2003) Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect 111:201–205. https://doi.org/10.1289/ehp.5742
Petit C, Chevrier C, Durand G, Monfort C, Rouget F, Ronan Garlantezec R, Cordier S (2010) Impact on fetal growth of prenatal exposure to pesticides due to agricultural activities: a prospective cohort study in Brittany. France Environ Health 9:71 http://www.ehjournal.net/content/9/1/71
Quintana MM, Vera B, Magnarelli G, Guiñazú N, Rovedatti MG (2017) Neonate, placental and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application. Environ Sci Pollut Res 24:20736–20746. https://doi.org/10.1007/s11356-017-9642-9
Raatikainen K, Huurinainen P, Heinonen S (2007) Smoking in early gestation or through pregnancy: a decision crucial to pregnancy outcome. Prev Med 44(1):59–63. https://doi.org/10.1016/j.ypmed.2006.07.017
Rappazzo KM, Warren JL, Meyer RE, Herring AH, Sanders AP, Brownstein NC, Luben TJ (2016) Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Res A 106:240–249. https://doi.org/10.1002/bdra.23479
Rauch SA, Braun JM, Barr DB, Calafat AM, Khoury J, Montesano MA, Yolton K, Lanphear BP (2012) Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birthweight. Environ Health Perspect 120(7):1055–1060. https://doi.org/10.1289/ehp.1104615
Rauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, Whyatt R (2011) Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect 119(8):1196–1201. https://doi.org/10.1289/ehp.1003160
Rivero - Osimani VL, Valdez SR, Guiñazú N, Magnarelli G (2016) Alteration of syncytiotrophoblast mitochondria function and endothelial nitric oxide synthase expressionin the placenta of rural residents. Reprod Toxicol 61:47–57. https://doi.org/10.1016/j.reprotox.2016.02.018
Roje D, Ivo B, Ivica T, Mirjana V, Vesna C, Aljosa B, Marko V, Zoran M, Marko M, Tomislav M (2004) Gestational age — the most important factor of neonatal ponderal index. Yonsei Med J 45(2):273–280. https://doi.org/10.3349/ymj.2004.45.2.273
Roshdy Ahmed S, El-Khatem El-Sammani M, Al-Alaziz Al-Sheeha M, Saeed Aitallah A, Jabin Khan F, Roshdy Ahmed S (2012) Pregnancy outcome in women with threatened miscarriage: a year study. Mat Soc Med 24(1):26–28. https://doi.org/10.5455/msm.2012.24.26-28
Rovedatti MG, Trapassi JH, Vela L, López A, Santa Cruz S y Magnarelli G (2006) Environmental health prevention for populations exposed to pesticides: interviews in rural communities and educational workshop for multiplier agents. Acta Toxicol Argent 14 (1): 1-6, [in Spanish]. https://www.toxicologia.org.ar/bibliotecavirtual/acta_toxicologica/vol14-1.pdf
Rowe C, Gunier R, Bradman A, Harley KG, Kogut K, Parra K, Eskenazi B (2016) Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children. Environ Res 150:128–137. https://doi.org/10.1016/j.envres.2016.05.048
Rull RP, Ritz B, Shaw GM (2006) Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol 163(8):743–753. https://doi.org/10.1093/aje/kwj101
Ryberg MW, Rosenbaum RK, Mosqueron L, Fantke P (2018) Addressing bystander exposure to agricultural pesticides in life cycle impact assessment. Chemosphere 197:541–549. https://doi.org/10.1016/j.chemosphere.2018.01.088
Sagiv SK, Harris MH, Gunier RB, Kogut KR, Harley KG, Deardorff J, Bradman A, Holland N, Eskenazi B (2018) Prenatal organophosphate pesticide exposure and traits related to autism spectrum disorders in a population living in proximity to agriculture. Environ Health Perspect 126(4):047012. https://doi.org/10.1289/EHP2580
Salihu HM, Wilson RE (2007) Epidemiology of prenatal smoking and perinatal outcomes. Early Hum Dev 83:713–720. https://doi.org/10.1016/j.earlhumdev.2007.08.002
Sánchez S, Vera B, Montagna C, Magnarelli G (2015) Characterization of placental cholinesterases and activity induction associated to environmental organophosphate exposure. Toxicol Rep 2:437–442. https://doi.org/10.1016/j.toxrep.2014.11.013
Santa- Cruz S, Magnarelli G, Rovedatti MG (2020) Evaluation of endocrine disruption and gestational disorders in women residing in areas with intensive pesticide application: an exploratory study. Environ Toxicol Pharmacol 73:103280. https://doi.org/10.1016/j.etap.2019.103280
Sapbamrer R, Hongsibsong S (2019) Effects of prenatal and postnatal exposure to organophosphate pesticides on child neurodevelopment in different age groups: a systematic review. Environ Sci Pollut Res 26:18267–18290. https://doi.org/10.1007/s11356-019-05126-w
Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I (2014) Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environ Health Perspect 122(10):1103–1109. https://doi.org/10.1289/ehp.1307044
Souza MS, Magnarelli GG, Rovedatti MG, Santa-Cruz S, Pechen de D’Angelo AM (2005) Prenatal exposure to pesticides: analysis of human placental acetylcholinesterase, glutathione-S-transferase and catalase as biomarkers of effect. Biomarkers 10(5):376–389. https://doi.org/10.1080/13547500500272614
Stillerman KP, Mattison DR, Giudice LC, Woodruff TJ (2008) Environmental exposures and adverse pregnancy outcomes: a review of the science. Reprod Sci 15:631–650. https://doi.org/10.1177/1933719108322436
Tosi A, de D’Angelo AM P, Savini MC, Loewy MC (2009) Pesticide risk analysis on surface water of the Northern Argentine Patagonic region. Acta Toxicol Argent 17(1):1–6 [in Spanish]. https://toxicologia.org.ar/bibliotecavirtual/acta_toxicologica/ata17_1.pdf
van den Berg F, Kubiak R, Benjey WG, Majewski MS, Yates SR, Reeves G, Smelt JH, van der Linden AMA (1999) Emission of pesticides into the air. Water Air Soil Pollut 115:195–218. https://doi.org/10.1023/A:1005234329622
Vardavas CI, Plada M, Tzatzarakis M, Marcos A, Warnberg J, Gomez- Martinez S, Breidenassel C, Gonzalez-Gross M, Tsatsakis AM, Saris WH, Moreno LA, Kafatos AG (2010) Passive smoking alters circulating naive/memory lymphocyte T-cell subpopulations in children. Pediatr Allergy Immunol 21:1171–1178. https://doi.org/10.1111/j.1399-3038.2010.01039.x
Venners SA, Korrick S, Xu X, Chen C, Guang W, Huang A, Altshul L, Perry M, Fu L, Wang X (2005) Preconception serum DDT and pregnancy loss: a prospective study using a biomarker of pregnancy. Am J Epidemiol 162(8):709–716. https://doi.org/10.1093/aje/kwi275
Vera B, Santa- Cruz S, Magnarelli G (2012) Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associatedwith maternal exposure to pesticides. Reprod Toxicol 34(3):402–407. https://doi.org/10.1016/j.reprotox.2012.04.007
Wang Y, Chen HJ (2012) Use of percentiles and Z -Scores in anthropometry. In: Preedy VR (ed) Handbook of anthropometry: physical measures of human form in health and disease. Springer Science+Business Media, New York, LLC, pp 29–48. https://doi.org/10.1007/978-1-4419-1788-1_2
Wang P, Tian Y, Wang XJ, Gao Y, Shi R, Wang GQ, Hu GH, Shen XM (2012) Organophosphate pesticide exposure and perinatal outcomes in Shanghai. China Environ Internat 42:100–104. https://doi.org/10.1016/j.envint.2011.04.015
Wang Y, Zhang Y, Ji L, Hu Y, Zhang J, Wang C, Ding G, Chen L, Kamijima M, Ueyama J, Gao Y, Tian Y (2017) Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong. China Environ Int 108:119–126. https://doi.org/10.1016/j.envint.2017.08.010
Weselak M, Arbuckle TE, Wigle DT, Krewski D (2007) In utero pesticide exposure and childhood morbidity. Environ Res 103(1):79–86. https://doi.org/10.1016/j.envres.2006.09.001
Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, Hoepner LA, Diaz D, Dietrich J, Reyes A, Tang D, Kinney PL, Perera FP (2004) Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ Health Perspect 112:1125–1132. https://doi.org/10.1289/ehp.6641
Wigle DT, Arbuckle TE, Turner MC, Bérubé A, Yang Q, Liu S, Krewski D (2008) Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev 11:373–517. https://doi.org/10.1080/10937400801921320
Winchester PD, Huskins J, Ying J (2009) Agrochemicals in surface water and birth defects in the United States. Acta Paediatr 98(4):664–669. https://doi.org/10.1111/j.1651-2227.2008.01207.x
Wohlfahrt-Veje C, Main KM, Schmidt IM, Boas M, Jensen TK, Grandjean P, Skakkebæk NE, Andersen HR (2011) Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study. Environ Health 10:79. https://doi.org/10.1186/1476-069X-10-79
Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(1):e1–e20. https://doi.org/10.1016/j.fertnstert.2008.01.065
Woskie S, Kongtip P, Thanasanpaiboon W, Kiatdamrong N, Charoonrungsirikul N, Nankongnab N, Anu Surach A, Phamonphon A (2017) A pilot study of maternal exposure to organophosphate pesticides and newborn neurodevelopment in Thailand. Int J Occup Environ Health 23(3):193–201. https://doi.org/10.1080/10773525.2018.1450324
Zhang J, Cai WW, Lee DJ (1992) Occupational hazards and pregnancy outcomes. Am J Ind Med 21:397–408. https://doi.org/10.1002/ajim.4700210312
Acknowledgements
We thank all the women participating in this study, as well as the health agents who collaborated, especially Dr. Silvia Santa Cruz, nurse midwife Carina Romero, the staff of the Gynecology Service of the General Roca City Hospital, the Laboratory Staff of the Maternity Service and the Statistical Service of Dr. E. Accame Hospital of Allen City.
Funding
This research was conducted with the support of the Fellowship “Ramón Carrillo - Arturo Oñativia” Institutional Projects, issued by the Argentine National Ministry of Health, through the Argentine National Health Research (ECM 2010), and grants from Universidad Nacional del Comahue (I004/3) and Argentine National Agency for the Promotion of Science and Technology, FONCyT (PICT-Redes 2007-00214).
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AC: Methodology, Investigation, Data Curation, Resources
GA: Methodology, Investigation, Resources
NQ: Investigation, Data Curation
MCB: Investigation, Data Curation
SA: Investigation, Data Curation
GS: Formal analysis
GGM: Conceptualization, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition
MGR: Conceptualization, Writing - Review & Editing, Visualization, Supervision, Project administration, Funding acquisition
All authors read and approved the final manuscript.
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The study protocol was approved by the ethical committee of the local Advisory Committee of Biomedical Research in Humans.
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Amalia Cecchi, Gabriel Alvarez, Natalia Quidel, María Cecilia Bertone, Guillermo Sabino, and Gladis G. Magnarelli participated in the design, execution, and analysis of the paper entitled Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameter, have seen and approved the final version, and that it has neither been published nor submitted elsewhere.
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Not applicable.
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The authors declare no competing interests.
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Highlights
• Higher threatened miscarriage was the pregnancy complication associated to residential proximity to Patagonian fruit croplands with pesticide applications.
• Lower length at birth was associated to residential proximity to the fruit croplands in High Valley of Negro River, in Argentine Patagonia.
• Women living within a short distance of this agricultural field had babies with lower head circumference at birth.
• Higher ponderal index in newborns was associated to residential proximity to this fruit-growing zone.
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Cecchi, A., Alvarez, G., Quidel, N. et al. Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters. Environ Sci Pollut Res 28, 56565–56579 (2021). https://doi.org/10.1007/s11356-021-14574-2
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DOI: https://doi.org/10.1007/s11356-021-14574-2