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Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia

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Abstract

Bisphenol A (BPA) is a chemical endocrine disruptor to which humans are often exposed in daily life. Postnatal administration of BPA results in schizophrenia (SCZ)-like behaviours in rats. The present study was designed to elucidate whether treatment with astragaloside IV (ASIV) or saponins extracted from Astragalus spinosus improves the neurobehavioural and neurochemical disturbances induced by BPA. Fifty-two juvenile (PND20) male Sprague Dawley rats were divided into four groups. The rats in Group I were considered the control rats, while the rats in Group II were orally administered BPA (125 mg/kg) daily from PND20 to adult age (PND117). The rats in the third and fourth groups were administered BPA (125 mg/kg/day) supplemented with astragaloside IV (80 mg/kg/d) on PND20 or A. spinosus saponins (100 mg/kg/d) from PND50 to PND117, respectively. Administration of ASIV and saponins extracted from Astragalus spinosus reversed the anxiogenic and depressive-like behaviours and the social defects that were observed in the rats treated with BPA alone. Additionally, these compounds improved memory impairments, restored dopamine (DA), serotonin (5-HT), and monoamine oxidase (MAO-A) levels and normalized Tph2 mRNA expression towards the control values. Taken together, it can be concluded that orally administered ASIV and A. spinosus saponins exhibit neuroprotective effects and that these compounds can be used as therapeutic strategies against BPA-induced neuropsychiatric symptoms in a rat model of SCZ.

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  1. Zoology, Biological and Geological Sciences Department, Faculty of Education, Alexandria University, Alexandria, Egypt

    Heba-Tallah Abd Elrahim Abd Elkader

  2. Zoology Department, Faculty of Science, Alexandria University, Alexandria, Egypt

    Heba Mohamed Abdou & Amina Essawy Essawy

  3. Department of Genetic Engineering and Biotechnology, Institute of Genetic Engineering and Biotechnology, Sadat City University, Sadat City, Egypt

    Omaima Ahmed Khamiss

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  1. Heba-Tallah Abd Elrahim Abd Elkader
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Heba-Tallah Abd Elkader was responsible for the idea, performed experiments and made the statistical analysis of the data, Dr. Heba Mohamed Abdou was responsible for the design of the study. Heba-Tallah Abd Elkader, Dr. Heba Mohamed Abdou, Dr. Omaima Ahmed Abdel-Maguid Khamiss and Dr Amina Essawy Essawy are responsible for writing and revising the manuscript. Also, all authors have read and approved the manuscript.

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Abd Elkader, HT.A.E., Abdou, H.M., Khamiss, O.A. et al. Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia. Environ Sci Pollut Res 28, 35171–35187 (2021). https://doi.org/10.1007/s11356-021-12927-5

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