Skip to main content

Advertisement

Log in

Trends in the levels of urine and serum creatinine: data from NHANES 2001–2014

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

Data from the National Health and Nutrition Examination Survey were used to study trends for urine and serum creatinine over 2001–2014 for those aged ≥20 years. In the absence of chronic kidney disease, levels of urine creatinine decreased for the total population, for those aged 20–29, 50–59, and ≥70 years, for males, and for Mexican Americans and other race/ethnicities. Levels of serum cotinine also exhibited a decreasing trend over 2001–2014 for the total population, for those aged 20–29 and 40–49 years, for females, and for non-Hispanic whites and Mexican Americans. In general, levels of serum creatinine and urine creatinine were positively correlated for chronic kidney disease stages 1–3 and negatively correlated for chronic kidney disease stages 4 and 5.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, de Boer IH (2013) Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol 24(2):302–308. doi:10.1681/ASN.2012070718

    Article  CAS  Google Scholar 

  • Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL (2005) Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 113:192–200

    Article  CAS  Google Scholar 

  • de Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, Himmelfarb J (2011) Temporal trends in the prevalence of diabetic kidney disease in the United States. J Am Med Assoc 305(24):2532–2539. doi:10.1001/jama.2011.861

    Article  Google Scholar 

  • Duru OK, Vargas RB, Kermah D, Nissenson AR, Norris KC (2009) High prevalence of stage 3 chronic kidney disease in older adults despite normal serum creatinine. J Gen Intern Med 24(1):86–92. doi:10.1007/s11606-008-0850-3

    Article  Google Scholar 

  • Foley RN (2010) Temporal trends in the burden of chronic kidney disease in the United States. Current Opinions in Nephrology and Hypertension 19(3):273–277. doi:10.1097/MNH.0b013e328337bba7

    Article  Google Scholar 

  • Fram, E.B., S. Moazami, and J.M. Stern. (2015) “The effect of disease severity on 24-hour urine parameters in kidney stone patients with type II diabetes.” Urology pii: S0090-4295(15)00992-9. doi: 10.1016/j.urology.2015.10.013.

  • Gambaro GTY, Graziani MS, Gemelli A, Abaterusso C, Frigo AC, Marchionna N, Citron L, Bonfante L, Grigoletto F, Tata S, Ferraro PM, Legnaro A, Meneghel G, Conz P, Rizzotti P, D’Angelo A, Lupo A, INCIPE Study Group (2010) Prevalence of CKD in northeastern Italy: results of the INCIPE study and comparison with NHANES. Clin J Am Soc Nephrol 5(11):1946–1953. doi:10.2215/CJN.02400310

    Article  Google Scholar 

  • Grams ME, Juraschek SP, Selvin E, Foster MC, Inker LA, Eckfeldt JH, Levey AS, Coresh J (2013) Trends in the prevalence of reduced GFR in the United States: a comparison of creatinine and cystatin C-based estimates. Am J Kidney Dis 62(2):253–260. doi:10.1053/j.ajkd.2013.03.013

    Article  CAS  Google Scholar 

  • Lascano, M.E., and E.D. Poggio. 2010. “Kidney function assessment by creatinine-based estimation equations. 2010.” Available at www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/nephrology/kidney-function/. Last accessed on December 28, 2015.

  • Levey ASJC, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek W, Van Lente F, Chronic Kidney Disease Epidemiology Collaboration (2006) Using standardized serum creatinine values in the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate. Ann Intern Med 145(4):247–254

    Article  CAS  Google Scholar 

  • Levey AS, Stevens LA, Schmid CS, Zhang YL, Castro AS III, Feldman HI, Kusak JW, Eggers P, Van Lente F, Green T, Coresh J, MHS (2009) A new equation to estimate glomerular filtration rate. Annals Internal Medicine 150:604–612

    Article  Google Scholar 

  • McCullough PA, Li S, Jurkovitz CT, Stevens LA, Wang C, Collins AJ, Chen SC, Norris KC, McFarlane SI, Johnson B, Shlipak MG, Obialo CI, Brown WW, Vassalotti JA, Whaley-Connell AT, Investigators KEEP (2008) CKD and cardiovascular disease in screened high-risk volunteer and general populations: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004. Am J Kidney Dis 51(4 Suppl 2):S38–S45. doi:10.1053/j.ajkd.2007.12.017

    Article  Google Scholar 

  • Murphy D, McCulloch CE, Lin F, Banerjee T, Bragg-Gresham JL, Eberhardt MS, Morgenstern H, Pavkov ME, Saran R, Powe NR, Hsu CY; Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team. “Trends in Prevalence of Chronic Kidney Disease in the United States.” Ann Intern Med 2016;165(7):473–481.

  • Odden MC, Amadu AR, Smit E, Lo L, Peralta CA (2014) Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002. Am J Kidney Dis 64(4):550–557. doi:10.1053/j.ajkd.2014.04.024

    Article  CAS  Google Scholar 

  • Odutayo, A., A.J. Hsiao, and C.A. Emdin (2016) “Prevalence of albuminuria in a general population cohort of patients with established chronic heart failure.” Journal of Cardiac Failure 22:33–37 pii: S1071-9164(15)01156-2. doi: 10.1016/j.cardfail.2015.10.009.

  • Ricardo AC, Fischer MJ, Peck A, Turyk M, Lash JP (2010) Depressive symptoms and chronic kidney disease: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Int Urol Nephrol 42(4):1063–1068. doi:10.1007/s11255-010-9833-5

    Article  CAS  Google Scholar 

  • Ricardo AC, Grunwald JE, Parvathaneni S, Goodin S, Ching A, Lash JP (2014) Retinopathy and CKD as predictors of all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 1988-1994. Am J Kidney Dis 64(2):198–203. doi:10.1053/j.ajkd.2014.01.437

    Article  Google Scholar 

  • Ricardo AC, Flessner MF, Eckfeldt JH, Eggers PW, Franceschini N, Go AS, Gotman NM, Kramer HJ, Kusek JW, Loehr LR, Melamed ML, Peralta CA, Raij L, Rosas SE, Talavera GA, Lash JP (2015a) Prevalence and correlates of CKD in Hispanics/Latinos in the United States. Clin J Am Soc Nephrol 10(10):1757–1766. doi:10.2215/CJN.02020215

    Article  CAS  Google Scholar 

  • Ricardo AC, Athavale A, Chen J, Hampole H, Garside D, Marucha P, Lash JP (2015b) Periodontal disease, chronic kidney disease and mortality: results from the third National Health and Nutrition Examination Survey. BMC Nephrol 216:97. doi:10.1186/s12882-015-0101-x

    Article  Google Scholar 

  • Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol (3):629–637. doi:10.1681/ASN.2008030287

  • Schwartz GJ, Work DF (2009) Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 4(11):1832–1843. doi:10.2215/CJN.01640309

    Article  Google Scholar 

  • Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J, Rossert J, Van Lente F, Bruce RD 3rd, Zhang YL, Greene T, Levey AS (2008) Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 51(3):395–406. doi:10.1053/j.ajkd.2007.11.018

    Article  CAS  Google Scholar 

  • Stevens LA, Li S, Wang C, Huang C, Becker BN, Bomback AS, Brown WW, Burrows NR, Jurkovitz CT, McFarlane SI, Norris KC, Shlipak M, Whaley-Connell AT, Chen SC, Bakris GL, McCullough PA (2010) Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis 55(3 Suppl 2):S23–S33. doi:10.1053/j.ajkd.2009.09.035

    Article  Google Scholar 

  • Stiegel MA, Pleil JD, Sobus JR, Angrish MM, MorganK MK (2015) Kidney injury biomarkers and urinary creatinine variability in nominally healthy adults. Biomarkers 20:436–452

    Article  CAS  Google Scholar 

  • Targher G, Bosworth C, Kendrick J, Smits G, Lippi G, Chonchol M (2009) Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006. Clin Chem Lab Med 47(9):1055–1062. doi:10.1515/CCLM.2009.244

    Article  CAS  Google Scholar 

  • Wang HE, Gamboa C, Warnock DG, Muntner P (2011) Chronic kidney disease and risk of death from infection. Am J Nephrol 34(4):330–336. doi:10.1159/000330673

    Article  Google Scholar 

  • Whaley-Connell A, Sowers JR, McCullough PA, Roberts T, McFarlane SI, Chen SC, Li S, Wang C, Collins AJ, Bakris GL, Investigators KEEP (2009) Diabetes mellitus and CKD awareness: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES). Am J Kidney Dis 53(4 Suppl 4):S11–S21. doi:10.1053/j.ajkd.2009.01.004

    Article  CAS  Google Scholar 

  • Wu CK, Chang MH, Lin JW, Caffrey JL, Lin YS (2011) Renal-related biomarkers and long-term mortality in the US subjects with different coronary risks. Atherosclerosis 216(1):226–236. doi:10.1016/j.atherosclerosis.2011.01.046

    Article  CAS  Google Scholar 

  • Xu R, Zhang L, Zhang P, Wang F, Zuo L, Wang H (2009) Comparison of the prevalence of chronic kidney disease among different ethnicities: Beijing CKD survey and American NHANES. Nephrol Dial Transplant 24(4):1220–1226. doi:10.1093/ndt/gfn609

    Article  Google Scholar 

Download references

Acknowledgement

Funding

The author declares that he did not receive any funds to conduct this research, and all data used in this research are available free of charge from www.cdc.gov/nchs/nhanes.htm.

Disclosure

The author had no financial or other conflicts including employment that could have affected the conclusions arrived at in this communication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ram B. Jain.

Additional information

Responsible editor: Philippe Garrigues

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jain, R.B. Trends in the levels of urine and serum creatinine: data from NHANES 2001–2014. Environ Sci Pollut Res 24, 10197–10204 (2017). https://doi.org/10.1007/s11356-017-8709-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-017-8709-y

Keywords

Navigation