Skip to main content

Advertisement

SpringerLink
Log in

Effects of sublethal Abamectin exposure on some hormonal profiles and testicular histopathology in male albino rats and the possible ameliorative role of Eruca sativa

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

The ameliorative role of Eruca sativa on some hormonal profile and testicular histopathology in male albino rats exposed to a sublethal dose of 1 mg/kg body weight (b.wt). Abamectin (Crater 3.37% EC) was evaluated. Eighteen male albino rats were divided into three groups: control group, Abamectin-treated group, and Abamectin + E. sativa-treated group. Rats of the second group were orally administrated 1 mg/kg b.wt. of Abamectin, the third group received a mixture of sublethal oral dose of Abamectin (1 mg/kg b.wt.) and E. sativa suspension (5 g/kg b.wt.) every 48 h for 28 days. At the end of the study, blood samples were collected from all groups to measure some hormonal parameters; also, rats were dissected and tissue sections from the testes were prepared and stained with hematoxylin and eosin for examination under light microscope. The results of the present study revealed a disturbance in the hormonal parameters and some testicular histopathological changes. In addition, administration of E. sativa might have a promising effect against Abamectin toxicity-induced disorders of thyroid hormones and impaired testicular functions, which were correlated with histopathological changes in the testes of male rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  • Abd-Elhady HK, Abou-Elghar GE (2013) Abamectin induced biochemical and istopathological changes in the albino rat, Rattus norvegicus. J Plant Prot Res 53:263–270

    Article  CAS  Google Scholar 

  • Ahmed SA, Mohammed AA, Saadoon AH (2013) The effect of Eurca saliva alcoholic extract in decreasing the induced toxicity of liver and kidney in mice. Eng & Tech Journal 31:574–580

    Google Scholar 

  • Al-Daraji HJ, Razuki RH (2012) Effect of dietary supplementation with different levels of rocket salad (Eruca sativa) seeds powder on blood plasma traits of white Hy-line laying breeder roosters. Kufa J Agric Sci 4:31–42

    Google Scholar 

  • Al-Okbi SY, Mohamed DA, Hamed TE, Esmail RSH, Donya SM (2014) Prevention of renal dysfunction by nutraceuticals prepared from oil rich plant foods. Asian Pac J Trop Biomed 4:618–626

  • Ansari MN, Ganaie MA (2014) Ameliorative effect of rocket leaves on fertility in streptozotocin-induced diabetic rats. Int Res J Biological Sci 3:89–97

    Google Scholar 

  • Burtis CA, Ashwood ER (eds) (1994) Tietz textbook of clinical chemistry, 2nd edn. W B Saunders Company, Philadelphia

  • Dutta HM, Meijer HJ (2003) Sublethal effects of diazinon on the structure of the testis of bluegill, Lepomis macrochirus: a microscopic analysis. Environ Pollut 125:355–360

    Article  CAS  Google Scholar 

  • Eissa FI, Zidan NA (2010) Haematological, biochemical and histopathological alterations induced by Abamectin and Bacillus thuringiensis in male albino rats. Acta Biol Hung 61:33–44

    Article  CAS  Google Scholar 

  • El-Kashoury AA, Salama AF, Selim AI, Mohamed RA (2010) Chronic exposure of dicofol promotes reproductive toxicity in male rats. Life Sci J 7:5–19

    Google Scholar 

  • Felig P, Baxter JD, Broadus AE, Frohman LA (1987) Endocrinology and metabolism, 2nd Ed. New York, McGraw-Hill book Co, pp 408-416

  • Gomes WR (1977) Pharmacological agents and male fertility in the testes, Vol IV, A.D. Johnson AD, Gomes WR, (eds), Academic Press, New York, pp 605-628

  • Hanafi EM, Hegazy EM, Riad RM, Amer HA (2010) Bio-protective effect of Eruca Sativa seed oil against the hazardus effect of aflatoxin B1 in male – rabbits. Int J Acad Res 2:67–74

    Google Scholar 

  • Hay ID, Klee GG (1993) Linking medical needs and performance goals: clinical and laboratory perspectives on thyroid disease. Clin Chem 39:1519–1524

    CAS  Google Scholar 

  • Hotz KJ, Wilson AG, Thake DC, Roloff MV, Capen CC, Kronenberg JM, Brewster DW (1997) Mechanism of thiazopyr induced effects of thyroid hormone homeostasis in male Sprague-Dawley rats. Toxicol Appl Pharmacol 142:133–142

    Article  CAS  Google Scholar 

  • Hussein ZF (2013) Study the effect of Eruca sativa leaves extract on male fertility in albino mice. J Al-Nahrain University 16:143–146

    Google Scholar 

  • Hussein J, Salah A, Oraby F, El-Deen AN, El-Khayat Z (2010) Antihepatotoxic effect of Eruca sativa extracts on alcohol induced liver injury in rats. J Am Sci 6:381–389

    Google Scholar 

  • Ismail AA, Astley P, Burr WA, Cawood M, Short F, Wakelin K, Wheeler MJ (1986) The role of testosterone measurement in the investigation of androgen disorders. Ann Clin Biochem 23:113–134

    Article  Google Scholar 

  • Izumi H, Kimura E, Ota T, Shimazu S (2005) A two-generation reproductive toxicity study of n-butylbenzene in rats. J Toxicol Sci 30:21–38

    Article  CAS  Google Scholar 

  • Kevin M, Pantalone DO, Ecnu CCD (2012) Male hypogonadism: more than just a low testosterone. Clevel Clin J Med 79:717–725

    Article  Google Scholar 

  • Kuhn R, Bergham LR, Moons L, Vandesande F, Decuypere E, Darres M (1993) Hypothalamic and peripheral control of thyroid function during the life cycle of the chicken. In: Sharp PJ (Ed) Avian Endocrinology. J Endocrinology Ltd., Bristol 29–46

  • Lafuente A, Marquez N, Pousada Y, Pazo D, Esquifino AI (2000) Possible estrogenic and/or antiandrogenic effects of methoxychlor on prolactin release in male rats. Arch Toxicol 74:270–275

    Article  CAS  Google Scholar 

  • Lankas, G. R and Gordon, L. R. Toxicology. In Ivermectin and Abamectin. Campbell, W. C., Ed. Springer Verlag, New York, NY, 1989.10–142

  • Mahgoub AA, El-Medany AH (2001) Evaluation of chronic exposure of the male rat reproductive system to the insecticide methomyl. Pharm Res 44:73–80

    Article  CAS  Google Scholar 

  • Marzouk MA, Abassy MA, Mansour SA, Shaldam HA (2012) Toxic effects of Lambada-cyhalothrin on kidney functions and hormonal alterations in male albino rats: the role of zinc. Agric Res J 12:103–115

    Google Scholar 

  • McCann D, Kirkish L (1985) Evaluation of free testosterone in serum. J Clin Immunoass 8:234–236

    CAS  Google Scholar 

  • Mosbah R, Chouabia A, Yousef MI, Boulakoud MS (2008) Lorsban-induced changes in haematological parameters, testosterone and thyroxin levels, and semen quality of male rats. Rev Synthèse N° 18, Juillet: 35-44

  • Noha MM, Hanaa FH (2017) Protective effects of Eruca sativa (rocket) on Abamectin insecticide toxicity in male albino rats. Environ Sci Pollut Res 24(10):9702–9712

    Article  Google Scholar 

  • Putter I, Mac Connell JG, Preiser FA, Haidri AA, Ristich SS, Dybus RA (1981) Avermectins: novel insecticides, acaricides and nematicides fiom a soil microorganism. Experientia 37:963–964

    Article  CAS  Google Scholar 

  • Robinson WF, Huntable CR (1988) Clinicopathological principles for veterinary medicine. Cambridge Univ. Press, Sydney

    Book  Google Scholar 

  • Tag El-Din HA, Abbas HE, El-Kashoury AA (2003) Experimental studies of dicofol reproductive toxicity on male albino rats. Bull Fac Pharm Cairo Univ 41:179–188

    CAS  Google Scholar 

  • Uzunhisarcikli M, Kalender Y, Dirican K, Kalender S, Ogutcu A, Buyukkomurcu F (2007) Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and E. Pestic Biochem Physiol 87:115–122

    Article  CAS  Google Scholar 

  • Van den Berg KJ, Van Raaji JAGM, Bragt PC, Notten WRF (1991) Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65:15–19

    Article  Google Scholar 

  • Vinggaard AM, Hnida C, Breinholt V, Larsen JC (2000) Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol in Vitro 14:227–234

    Article  CAS  Google Scholar 

  • Vodo S, Bechi N, Petroni A, Muscoli C, Aloisi AM (2013) Testosterone-induced effects on lipids and inflammation. Mediators Inflammat 183041-183048

  • Witherspoon LR, Shuler SE (1984) Estimation of free thyroxine concentration: clinical methods and pitfalls. J Clin Immunoass 7:192–205

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt

    Hanaa Fawzy Hassan & Noha M. Meligi

Authors
  1. Hanaa Fawzy Hassan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noha M. Meligi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Hanaa Fawzy Hassan or Noha M. Meligi.

Additional information

Responsible editor: Philippe Garrigues

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hassan, H.F., Meligi, N.M. Effects of sublethal Abamectin exposure on some hormonal profiles and testicular histopathology in male albino rats and the possible ameliorative role of Eruca sativa . Environ Sci Pollut Res 24, 24690–24697 (2017). https://doi.org/10.1007/s11356-017-0112-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-017-0112-1

Keywords

Search

Navigation