Skip to main content
SpringerLink
Log in

The effect of continuous positive airway pressure (CPAP) on the quality of life in patients with multiple system atrophy

  • Sleep Breathing Physiology and Disorders • Short Communication
  • Published:
Sleep and Breathing Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the effect of continuous positive airway pressure (CPAP) on the quality of life (QoL) in patients with multiple system atrophy (MSA) and their caregivers.

Methods

We reviewed the electronic medical records of patients with MSA treated with CPAP (n = 15). After CPAP treatment, we checked the patient global impression of change (PGI-C) scale for sleep complaints and QoL for six patients who continued to use CPAP. QoL was also assessed for five caregivers of these patients.

Results

A total of 15 patients (6 women) were included. The mean age was 63.6 ± 8.1 years old and the mean disease duration was 4.9 years. The mean duration of CPAP treatment was 22.1 ± 10.6 months and the average compliance was 90%. Three patients died during CPAP treatment, and two patients discontinued CPAP after tracheostomy. For six patients who continued to use CPAP, sleep complaints minimally improved. Five patients reported an improved QoL, and all five caregivers reported improved caregivers’ QoL.

Conclusion

This study showed that the use of CPAP has a beneficial effect on sleep complaints and QoL of patients with MSA and their caregivers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Ghorayeb I, Yekhlef F, Chrysostome V, Balestre E, Bioulac B, Tison F (2002) Sleep disorders and their determinants in multiple system atrophy. J Neurol Neurosurg Psychiatry 72(6):798–800. https://doi.org/10.1136/jnnp.72.6.798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cortelli P, Calandra-Buonaura G, Benarroch EE, Giannini G, Iranzo A, Low PA et al (2019) Stridor in multiple system atrophy: consensus statement on diagnosis, prognosis, and treatment. Neurology 93(14):630–639. https://doi.org/10.1212/WNL.0000000000008208

    Article  PubMed  PubMed Central  Google Scholar 

  3. Giannini G, Calandra-Buonaura G, Mastrolilli F, Righini M, Bacchi-Reggiani ML, Cecere A et al (2016) Early stridor onset and stridor treatment predict survival in 136 patients with MSA. Neurology 87(13):1375–1383. https://doi.org/10.1212/WNL.0000000000003156

    Article  PubMed  Google Scholar 

  4. Silber MH, Levine S (2000) Stridor and death in multiple system atrophy. Mov Disord 15(4):699–704. https://doi.org/10.1002/1531-8257(200007)15:4%3c699::aid-mds1015%3e3.0.co;2-l

    Article  CAS  PubMed  Google Scholar 

  5. Iranzo A, Santamaria J, Tolosa E (2000) Continuous positive air pressure eliminates nocturnal stridor in multiple system atrophy. Barcelona Multiple System Atrophy Study Group. Lancet 356(9238):1329–30. https://doi.org/10.1016/s0140-6736(00)02824-5

    Article  CAS  PubMed  Google Scholar 

  6. Iranzo A, Santamaria J, Tolosa E, Vilaseca I, Valldeoriola F, Marti MJ et al (2004) Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy. Neurology 63(5):930–932. https://doi.org/10.1212/01.wnl.0000137043.76383.a4

    Article  CAS  PubMed  Google Scholar 

  7. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9):670–676. https://doi.org/10.1212/01.wnl.0000324625.00404.15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Sohn SI, Kim DH, Lee MY, Cho YW (2012) The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index. Sleep Breath 16(3):803–812. https://doi.org/10.1007/s11325-011-0579-9

    Article  PubMed  Google Scholar 

  9. Jung YJ, Kim HJ, Yoo D, Choi JH, Im JH, Yang HJ, Jeon B (2019) Various motor and non-motor symptoms in early multiple system atrophy. Neurodegener Dis 19(5–6):238–243. https://doi.org/10.1159/000507292

    Article  PubMed  Google Scholar 

  10. Watanabe H, Riku Y, Hara K, Kawabata K, Nakamura T, Ito M et al (2018) Clinical and imaging features of multiple system atrophy: challenges for an early and clinically definitive diagnosis. J Mov Disord 11(3):107–20. https://doi.org/10.14802/jmd.18020

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, South Korea

    Hee Jin Chang, Han-Joon Kim, Kyung Ah Woo, Jung Hwan Shin & Ki-Young Jung

Authors
  1. Hee Jin Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Han-Joon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung Ah Woo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jung Hwan Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ki-Young Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Han-Joon Kim or Ki-Young Jung.

Ethics declarations

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Seoul National University Hospital Ethics Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this retrospective study, formal consent is not required.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chang, H.J., Kim, HJ., Woo, K.A. et al. The effect of continuous positive airway pressure (CPAP) on the quality of life in patients with multiple system atrophy. Sleep Breath 27, 1481–1484 (2023). https://doi.org/10.1007/s11325-022-02739-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11325-022-02739-3

Keywords

Search

Navigation