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Association of serum asprosin concentrations with obstructive sleep apnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Objective

Asprosin, a recently discovered adipokine, stimulates the release of hepatic glucose. The purpose of the current research was to determine the relation between serum asprosin and obstructive sleep apnea syndrome (OSAS).

Methods

The current investigation enrolled 152 patients with OSAS and 97 control subjects. Serum asprosin concentrations were measured and analyzed.

Results

Higher serum asprosin concentrations were found in patients with OSAS than in the controls. Logistic regression analysis demonstrated that serum asprosin concentrations were associated with an increased risk of OSAS. Patients with severe OSAS had significantly increased asprosin compared to mild and moderate groups. The group with moderate OSAS showed higher serum asprosin levels than the group with mild OSAS. Pearson correlation analysis demonstrated a positive relation between serum asprosin and disease severity. Simple linear regression analyses showed a significant correlation between serum asprosin with body mass index (BMI), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), and apnea-hypopnea index (AHI), and negatively correlated with high-density lipoprotein cholesterol (HDL-C). Multiple linear regression analysis revealed a significant correlation between serum asprosin with BMI, FPG, HOMA-IR, TG, AHI, and HDL-C.

Conclusion

There is a significant correlation between serum asprosin with the presence and severity of OSAS.

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Data availability

Data are available upon reasonable request.

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Author notes

  1. Jurong Ding and Shanmei Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Emergency, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China

    Jurong Ding & Shanmei Wang

  2. Intensive Care Unit of Respiratory Medicine, Tongji University Affiliated Shanghai Pulmonary Hospital, 507 Zhengmin Road, Yangpu District, Shanghai, 200433, China

    Wei Tan, Xinmiao Song & Li Zhang

Authors
  1. Jurong Ding
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  2. Shanmei Wang
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  3. Wei Tan
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  4. Xinmiao Song
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  5. Li Zhang
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Contributions

Li Zhang planned this study. Jurong Ding and Shanmei Wang collected the data and performed the ELISA measurement. Wei Tan and Xinmiao Song did the statistical work. All authors approved the paper publication.

Corresponding author

Correspondence to Li Zhang.

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The authors declare no conflict of interest.

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Ding, J., Wang, S., Tan, W. et al. Association of serum asprosin concentrations with obstructive sleep apnea syndrome. Sleep Breath 25, 1893–1896 (2021). https://doi.org/10.1007/s11325-021-02298-z

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  • DOI: https://doi.org/10.1007/s11325-021-02298-z

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