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Changes of visual field and optic nerve fiber layer in patients with OSAS

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Abstract

Background

The prevalence of primary open-angle glaucoma (POAG) increases in obstructive sleep apnea syndrome (OSAS). OSAS could increase cerebrospinal fluid pressure (CSFP) and binocular papilledema.

Methods

In this cross-sectional study, intraocular pressure (IOP), CSFP, mean deviation (MD), pattern standard deviation (PSD), optic disc indices, and retinal nerve fiber layer (RNFL) were compared among four groups with different extents of OSAS. Regression analysis was performed to correlate MD, PSD, and RNFL to polysomnography (PSG) index. For subgroups with severe OSAS, IOP and CSFP were compared. The prevalence of POAG was calculated.

Results

The severe OSAS had a significantly higher CSFP than the other three groups (p = 0.002, 0.036, and 0.017). Both moderate and severe groups showed significantly higher IOP than control group (p = 0.022 and 0.001). MD was correlated with average oxygen saturation (MSaO2) (p = 0.001). PSD was correlated with oxygen desaturation index (ODI) (p = 0.004). Significant differences were found in nasal RNFL and inferior RNFL among the four groups (p = 0.013, p = 0.004). Nasal RNFL correlated with the ODI (p = 0.048). For severe group, compared to normal RNFL group, CSFP was significantly lower in the thinned RNFL group (p = 0.039) and higher in the thickened RNFL group (p = 0.034). Totally, the prevalence of POAG was 5.49 %.

Conclusions

OSAS had a high prevalence of POAG. Visual field was damaged and the RNFL was thinned. Due to diverse CSFP, RNFL changed differently in the patients with severe OSAS.

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Conflicts of interest

No authors have conflict of interest in this study.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, 2nd Anzhen Street, Chaoyang District, Beijing, China, 100029

    Chen Xin & Jun Wang

  2. Department of Respiration, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

    Wei Zhang & Li Wang

  3. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Diya Yang

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  1. Chen Xin
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  2. Wei Zhang
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  3. Li Wang
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  4. Diya Yang
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  5. Jun Wang
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Correspondence to Jun Wang.

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Xin, C., Zhang, W., Wang, L. et al. Changes of visual field and optic nerve fiber layer in patients with OSAS. Sleep Breath 19, 129–134 (2015). https://doi.org/10.1007/s11325-014-0978-9

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  • DOI: https://doi.org/10.1007/s11325-014-0978-9

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