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Feasibility of Imaging Small Animals on a 360° Whole-Body Cadmium Zinc Telluride SPECT Camera: a Phantom Study

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Abstract

Purpose

Single-photon emission computed tomography has found an important place in preclinical cancer research. Nevertheless, the cameras dedicated to small animals are not widely available. The present study aimed to assess the feasibility of imaging small animals by a newly released 360° cadmium zinc telluride camera (VERITON, Spectrum Dynamics, Israel) dedicated to human patients.

Procedures

A cylindrical phantom containing hot spheres was used to evaluate the intrinsic performance of the camera first without the presence of background activity and then with two contrasts between background and hot spheres (1/4 and 1/10). Acquisitions were repeated with different scan durations (10 and 20 min), two tested radioisotopes (Tc-99 m and I-123), and a set of reconstruction parameters (10 iterations [i] 8 subsets [s], 10i16s, 10i32s). A 3D-printed phantom mimicking a rat with four subcutaneous tumours was then used to test the camera under preclinical conditions.

Results

The results obtained from the micro-hollow sphere phantom showed that it was possible to visualize spheres with an inner diameter of 3.95 mm without background activity. Moreover, spheres with diameters of 4.95 mm can be seen in the condition of high contrast between background and spheres (1/10) and 7.86 mm with lower contrast (1/4). The rat-sized phantom acquisitions showed that 10- and 8-mm subcutaneous tumours were visible with a good contrast obtained for the two radioisotopes tested in this study. Both Tc-99 m and I-123 measurements demonstrated that a 10-min acquisition reconstructed with an ordered subset expectation maximization algorithm applying 10i32s was optimal to obtain sufficient image quality in terms of noise, resolution, and contrast.

Conclusion

Phantom results showed the ability of the system to detect sub-centimetre lesions for various radioisotopes. It seemed feasible to image small animals using a 360° cadmium zinc telluride gamma camera for preclinical cancer research purposes.

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Acknowledgements

Not applicable.

Funding

This study was funded by the Region de Normandie RIN 2017 and la Ligue Contre le Cancer.

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Authors and Affiliations

  1. Nuclear Medicine Department, University Hospital of Caen, Avenue de la Côte de Nacre, 14033, Caen, Cedex 9, France

    Cedric Desmonts & Nicolas Aide

  2. INSERM U1086 ANTICIPE, Normandy University, UNICAEN, Caen, France

    Cedric Desmonts, Nicolas Aide & Charline Lasnon

  3. Biomedical Department, Comprehensive Cancer Center F. Baclesse, UNICANCER, Caen, France

    Henry Austins

  4. Medical Physics Department, Comprehensive Cancer Center F. Baclesse, UNICANCER, Caen, France

    Cyril Jaudet

  5. Nuclear Medicine Department, Comprehensive Cancer Center F. Baclesse, UNICANCER, Caen, France

    Charline Lasnon

Authors
  1. Cedric Desmonts
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  2. Nicolas Aide
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  3. Henry Austins
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  4. Cyril Jaudet
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  5. Charline Lasnon
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Contributions

Study design and coordination: C.D., C.L.; Data collection: C.D., C.L.; Data analysis: C.D., C.J., C.L.; Phantom conception and printing: H.A., C.J., C.L.; Manuscript writing: C.D., N.A., C.L. All authors read and approved the final manuscript.

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Correspondence to Cedric Desmonts.

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Desmonts, C., Aide, N., Austins, H. et al. Feasibility of Imaging Small Animals on a 360° Whole-Body Cadmium Zinc Telluride SPECT Camera: a Phantom Study. Mol Imaging Biol 24, 1018–1027 (2022). https://doi.org/10.1007/s11307-022-01753-x

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  • DOI: https://doi.org/10.1007/s11307-022-01753-x

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