Abstract
Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.
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References
André P, Villain F (2017) Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review. Int J Cosmet Sci 39(4):355–360
Bäumchen C, Roth AHFJ., Biedendieck R, Malten M, Follmann M, Sahm H, Bringer-Meyer S, Jahn D (2007) D-Mannitol production by resting state whole cell biotransformation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megentarium. Biotechnol J 2:1408–1416
Brunker P, Altenbuchner J, Kulbe KD, Mattes R (1997) Cloning, nucleotide sequence and expression of a mannitol dehydrogenase gene from Pseudomonas fluorescens DSM 50106 in Escherichia coli. Biochim Biophys Acta 1351(1–2):157–167
Chenault HK, Whitesides GM (1987) Regeneration of nicotinamide cofactors for use in organic synthesis. Appl Biochem Biotechnol 14(2):147–197
Costenoble R, Adler L, Niklasson C, Lide G (2003) Engineering of the metabolism of Saccharomyces cerevisiae for anaerobic production of mannitol. FEMS Yeast Res 3(1):17–25
Dai YW, Meng Q, Mu W, Zhang T (2017) Recent advances in the applications and biotechnological production of mannitol. J Funct Foods 36:404–409
Dols M, Chraibi W, Simeon MR, Lindley ND, Monsan PF (1997) Growth and energetics of Leuconostoc mesenteroides NRRL B-1299 during metabolism of various sugars and their sequences for dextransucrase production. Appl Environ Microbiol 63(6):2159–2165
Fontes CPML., Honorato TL, Rabelo MC, Rodrigues S (2009) Kinetic study of mannitol production using cashew apple juice as substrate. Bioprocess Biosyst Eng 32(4):493–499
Fontes CPML., Silveira MS, Guilherme A, Fernandes FAN, Rodrigues S (2013) Substitution of yeast extract by ammonium sulfate for mannitol production in cashew apple juice. Biocatal Agric Biotechnol 2(1):69–75
Gaspar P, Neves AR, Ramos A, Gasson MJ, Shearman CA, Santos H (2004) Engineering Lactococcus lactis for production of mannitol: High yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system. Appl Environ Microbiol 70(3):1466–1474
Hattori K, Suzuki T (1974) Large scale production of erythritol and its conversion to D-mannitol production by n-alkane grown Candida zeylanoides. Agric Biol Chem 38(6):1203–1208
Helantoa M, Aarnikunnasb J, Weymarna NV, Airaksinena U, Palvab A, Matti L (2005) Improved mannitol production by a random mutant of Leuconostoc pseudomesenteroides. J Biotechnol 116(3):283–294
Kaup B, Bringer MS, Sahm H (2004) Metabolic engineering of Escherichia coli: construction of an efficient biocatalyst for D-mannitol formation in a whole-cell biotransformation. Appl Microbiol Biot 64(3):333–339
Kaup B, Bringer MS, Sahm H (2005) D-Mannitol formation from D-glucose in a whole-cell biotransformation with recombinant Escherichia coli. Appl Microbiol Biot 69(4):397–403
Korakli ME, Schwarz GW, Hammes WP (2000) Production of mannitol by Lactobacillus sanfranciscensis. Adv Food Sci 22:1–4
Kulbe KD, Schwab U, Gudernatsch W (2010) Enzyme-catalyzed production of mannitol and gluconic acid. Product recovery by various procedures. Ann N Y Acad 506(1):552–568
Laxman S, Savergave RV, Gadre BK, Jogdand VV (2012) Two-stage fermentation process for enhanced mannitol production using Candida magnoliae mutant R9. Bioprocess Biosyst Eng 36(2):193–203
Martinez GH, Barker A, Horecker BL (1963) A specific mannitol dehydrogenase from Lactobacillus brevis. J Biol Chem 238:1598–1603
Meng Q, Zhang T, Wei WT, Mu WM, Miao M (2017) Production of mannitol from a High concentration of glucose by Candida parapsilosis SK26.001. Appl Biochem Biotechnol 181:391–406
Nidetzky B, Haltrich D, Schmidt K, Schmidt H, Weber A, Kulbe KD (1996) Simultaneous enzymatic synthesis of mannitol and gluconic acid: II. Development of a continuous process for a coupled NAD(H)-dependent enzyme system. Biocatal Biotransfor 14(1):46–53
Parmentier S, Arnaut F, Soetaert W, Vandamme EJ (2003) Application of NAD-dependent polyol dehydrogenases for enzymatic mannitol/sorbitol production with coenzyme regeneration. Commun Agric Appl Biol 68(2 Pt A):255–262
Parmentier S, Arnaut F, Soetaert W, Vandamme EJ (2005) Enzymatic production of D-mannitol with Leuconostoc pseudomesenteroides mannitol dehydrogenase coupled to a coenzyme regeneration system. Biocatal Biotransformation 23(1):1–7
Patra F, Tomar S, Arora S (2009) Technological and functional applications of low-calorie sweeteners from lactic acid bacteria. J Food Sci 74(1):16–23
Quain DE, Boulton CA (1987) Growth and metabolism of mannitol by strains of Saccharomyces cerevisiae. J Gen Microbiol 133(7):1675–1684
Racine FM, Saha BC (2007) Production of mannitol by Lactobacillus intermedius NRRL B-3693 in fed-batch and continuous cell-recycle fermentations. Process Biochem 42(12):1609–1613
Rapoport SI (2001) Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drug 10(10):1809–1818
Reed R, Davison I, Chudek J, Foster R (1985) The osmotic role of mannitol in the Phaeophyta: an appraisal. Phycologia 24(1):35–47
Saha BC (2006a) A low-cost medium for mannitol production by Lactobacillus intermedius NRRL B-3693. Appl Microbiol Biotechnol 72(4):676–680
Saha BC (2006b) Production of mannitol from inulin by simultaneous enzymatic saccharification and fermentation with Lactobacillus intermedius NRRL B-3693. Enzyme Microb Tech 39(5):991–995
Saha BC (2006c) Effect of salt nutrients on mannitol production by Lactobacillus intermedius NRRL B-3693. J Ind Microbiol Biotechnol 33(10):887–890
Saha BC, Racine FM (2010) Effects of pH and corn steep liquor variability on mannitol production by Lactobacillus intermedius NRRL B-3693. Appl Microbiol Biotechnol 87(2):553–560
Saha BC, Racine FM (2011) Biotechnological production of mannitol and its applications. Appl Microbiol Biotechnol 89(4):879–891
Schneider KH, Giffhom F (1989) Purification and properties of a polyol dehydrogenase from the phototrophic bacterium Rhodobacter sphaeroides. Eur J Biochem 184(1):15–19
Schneider KH, Giffhorn F, Kaplan S (1993) Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides. J Gen Microbiol 139(10):2475–2248
Soetaert W (1990) Production of mannitol with Leuconostoc mesenteroides. Mededelingen van de Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent 55:1549–1552
Soetaert W (1991) Synthesis of D-mannitol and L-sorbose by microbial hydrogenation and dehydrogenation of monosaccharides. Ph.D. Thesis, University of Gent, Gent
Soetaert W, Vanhooren PT, Vandamme EJ (1999) The production of mannitol by fermentation. Methods Biotechnol 10:261–275
Song SH, Vieille C (2009) Recent advances in the biological production of mannitol. Appl Microbiol Biot 84(1):55–62
Song KH, Lee JK, Song JY, Hong SG, Baek H, Kim SY, Hyun HH (2002) Production of mannitol by a novel strain of Candida magnolia. Biotechnol Lett 24(1):9–12
Stoop JM, Mooibroek H (1998) Cloning and characterization of NADP mannitol dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress. Appl Environ Microbiol 64(12):4689–4696
Tomaszewska L, Rywin SA, Gładkowski W (2012) Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol. J Ind Microbiol Biot 39(9):1333–1343
Vick RTB, Mandel DK, Dea DK, Blanch HW, Wilke CR (1983) The application of recycle to continuous fermentative lactic acid production. Biotechnol Lett 5(10):665–670
Wang P, Ma J, Zhang Y, Zhang M, Wu M, Dai Z, Jiang M (2016) Efficient secretory overexpression of Endoinulinase in Escherichia coli and the production of inulooligosaccharides. Appl Biochem Biotechnol 179(5):880–894
Weymarn NV, Kiviharju K, Leisola M (2002) High-level production of D-mannitol with membrane cell-recycle bioreactor. J Ind Microbiol Biot 29(1):44–49
Wichmann R, Wandrey C, Buckmann AF, Kula MR (1981) Continuous enzymatic transformation in an enzyme membrane reactor with simultaneous NAD(H) regeneration. Biotechnol Bioeng 23(12):2789–2802
Wisselink HW, Weusthuisa RA, Egginka G, Hugenholtza J, Grobben GJ (2002) Mannitol production by lactic acid bacteria: a review. Int Dairy J 12(2):151–161
Wisselink HW, Moers AP, Mars AE, Hoefnagel MHN, Vos WM, Hugenholtz J (2005) Overproduction of heterologous mannitol 1-phosphatase: a key factor for engineering mannitol production by Lactococcus lactis. Appl Environ Microbiol 71(3):1507–1514
Yoshikawa J, Habe H, Morita T, Fukuoka T, Imura T, Iwabuchi H, Uemura S, Tamura T, Kitamoto D (2014) Production of mannitol from raw glycerol by Candida azyma. J Biosci Bioeng 117(6):725–729
Yue M, Cao HL, Zhang JP, Li SG, Meng YY, Chen W, Huang LS, Du YG (2013) Improvement of mannitol production by Lactobacillus brevismutant 3-A5 based on dual-stage pH control and fed-batch fermentations. World J Microbiol Biot 29(10):1923–1930
Zhang M, Gu L, Cheng C, Zhu JR, Wu H, Ma JF, Dong WL, Kong XP, Jiang M, Ouyang PK (2017) High-yield production of mannitol by Leuconostoc pseudomesenteroides CTCC G123 from chicory-derived inulin hydrolysate. J Ind Microbiol Biot 44(8):1237–1244
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The Key Science and Technology Project of Jiangsu Province (BE2016389), Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation (JSBEM2016010).
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Zhang, M., Gu, L., Cheng, C. et al. Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies. World J Microbiol Biotechnol 34, 41 (2018). https://doi.org/10.1007/s11274-018-2425-8
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DOI: https://doi.org/10.1007/s11274-018-2425-8