Abstract
Susceptibility to natural scrapie in sheep is associated with polymorphisms at codons 136, 154 and 171 of the prion protein (PrP) gene. To assess the risk of scrapie in sheep raised in China, DNA from 30 sheep of two breeds was isolated, amplified and sequenced for the PrP gene. The ovine PrP gene was found to be highly homogenous. The genotype associated with high susceptibility to scrapie (VRQ) was absent, whereas that associated with the resistance (ARR) was present in 6.7% of sheep examined. ARK was also rare (6.7%). ARQ that is associated with an intermediate susceptibility was the genotype observed in the most of sheep examined (86.6%). These data suggest that Chinese sheep of Mongolian sheep breed are susceptible to scrapie.
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Acknowledgments
This work was supported by National Key Technology Research and Development Program (Project No. 2006BAD06A13 and 2008BAI54B06) from the Ministry of Science and Technology, China.
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Han, CX., Liu, HX., Lu, YX. et al. Polymorphism of prion protein gene in sheep of Inner Mongolian, China. Virus Genes 42, 153–155 (2011). https://doi.org/10.1007/s11262-010-0549-5
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DOI: https://doi.org/10.1007/s11262-010-0549-5