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Sequence comparison of the right end of fowl adenovirus genomes

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Abstract

The nucleotide sequence at the right end of the genomes of fowl adenoviruses (FAdVs) representing species groups C (FAdV-4 CA and FAdV-10 C-2B), D (FAdV-2 CA), and E (FAdV-8 CA) was determined and analyzed and compared to FAdV-1 (species group A virus) and FAdV-9 A-2A (species group B virus). High nucleotide sequence identities and amino acid identities (74–94%) were found among viruses in the same species group. Homologues to known open reading frames (ORFs) of the right end of the reported FAdV genomes, such as lipase and Gam-1, were also found in all analyzed viral genomes. Homologues to a few FAdV ORFs were found in viruses other than FAdVs as well. Several novel FAdV ORFs were also found. Most identified ORFs have unknown function and thus further studies are necessary to establish their importance in virus replication. ORF content within the right end of the FAdV genomes varied among FAdVs, while the gene order and orientation of shared ORFs are conserved between different FAdVs.

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Acknowledgments

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA), Canada. Thanks go to Nadejda Romanova for providing technical support for some of the sequencing.

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Authors and Affiliations

  1. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1

    Juan Carlos Corredor, Amalia Garceac & Éva Nagy

  2. Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada, N1G 2W1

    Peter J. Krell

Authors
  1. Juan Carlos Corredor
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  2. Amalia Garceac
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  3. Peter J. Krell
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  4. Éva Nagy
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Corresponding author

Correspondence to Éva Nagy.

Additional information

Amalia Garceac and Juan Carlos Corredor share equally with first authorship. The sequences reported in this work have been deposited in GenBank with accession numbers EF458160-EF458163.

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Corredor, J.C., Garceac, A., Krell, P.J. et al. Sequence comparison of the right end of fowl adenovirus genomes. Virus Genes 36, 331–344 (2008). https://doi.org/10.1007/s11262-007-0194-9

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  • DOI: https://doi.org/10.1007/s11262-007-0194-9

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