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Technical feasibility of uro-dynamic MRI study of voiding biomechanics: a pilot study

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Abstract

Introduction

Dynamic volumetric MRI was used to non-invasively assess voiding biomechanics in a healthy male volunteer.

Methods

Using 3D Differential Subsampling with Cartesian Ordering (DISCO) Flex acquisition sequence, volumetric bladder images were obtained throughout the voiding effort. These were subsequently segmented using MIMICS. Segmented anatomical volumes were used to quantify total voided volume, post-void residual, volumetric displacement of urine over time, bladder neck angle, sphericity index, and prostatic urethral angle through the voiding effort.

Results

Bladder sphericity index correlated positively with flow rate. The greatest degree of bladder neck funneling correlated with the maximum urine flow rate. There was straightening of the prostatic urethral angle during voiding that also correlated positively with urine flow.

Conclusion

This pilot study confirms the potential of dynamic MRI to provide non-invasive assessment of lower urinary tract anatomy and biomechanics during voiding.

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Data availability

The participants of this study did not give written consent for their data to be shared publicly, so due to the sensitive nature of the research, supporting data are not available.

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Funding

The publishing of this study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases: R01 DK126850-01 and the National Institute of Diabetes and Digestive and Kidney Diseases Complications Consortium (Diacomp): DK 076169.

Author information

Authors and Affiliations

  1. Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, USA

    Juan Pablo Gonzalez-Pereira

  2. Department of Radiology, University of Wisconsin-Madison, Madison, USA

    Cody John Johnson & Shane Wells

  3. Department of Urology, University of Wisconsin-Madison, Madison, USA

    Wade Bushman

  4. Department of Mechanical Engineering, Department of Radiology, Department of Biomedical Engineering and Department of Urology, University of Wisconsin-Madison, Madison, USA

    Alejandro Roldan-Alzate

Authors
  1. Juan Pablo Gonzalez-Pereira
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  2. Cody John Johnson
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  3. Shane Wells
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  4. Wade Bushman
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  5. Alejandro Roldan-Alzate
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Corresponding author

Correspondence to Alejandro Roldan-Alzate.

Ethics declarations

Conflict of interest

All the authors declare no conflicts of interest.

Ethical approval

All subjects participated voluntarily and received a small compensation. The participants provide their written informed consent to participate in this University of Wisconsin-Madison IRB-approved study (2021–1247). Institution: University of Wisconsin-Madison. Ethical Approval Number (IRB ID): 2021-1247.

Patient consent

Patients have reviewed and signed the consent to participate in this study. This study is compliant with the Health Insurance Portability and Accountability Act.

Clinical trial registration number

This study does not require a clinical trial registration because it is a technical study that introduces a novel technology for assessing bladder anatomy non-invasively in a dynamic way but does not focus on a health condition or treatment.

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Cite this article

Gonzalez-Pereira, J.P., Johnson, C.J., Wells, S. et al. Technical feasibility of uro-dynamic MRI study of voiding biomechanics: a pilot study. Int Urol Nephrol 56, 893–899 (2024). https://doi.org/10.1007/s11255-023-03823-7

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  • DOI: https://doi.org/10.1007/s11255-023-03823-7

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