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Prevalence and co-incidence of geriatric syndromes according to glomerular filtration rate in older patients

  • Nephrology - Original Paper
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Abstract

Background

Geriatric syndromes are complex clinical manifestations and significant causes of mortality and morbidity. This study was aimed to determine the frequency and co-incidence of geriatric syndromes in older patients with chronic kidney disease (CKD).

Methods

Older patients were included in this cross-sectional retrospective study. All patients were questioned in terms of geriatric syndromes including dementia, polypharmacy, malnutrition, frailty, probable sarcopenia, urinary incontinence, falls, fear of falling, depression, insomnia, and excessive daytime sleepiness. Geriatric syndromes were evaluated according to Glomerular Filtration Rate (GFR) ≥ 60 ml/min/1.73 m2, 30–59 ml/min/1.73 m2 and < 30 ml/min/1.73 m2.

Results

Of the 1320 patients included, the mean age was 79.6 ± 7.8 and 929 (70%) were female. GFR groups ≥ 60 ml/min/1.73 m2, 30–59 ml/min/1.73 m2, and < 30 ml/min/1.73 m2 comprised of 55%, 38%, and 7% patients, respectively. The rate of ≥ 3 syndromes in the same person was 66.4% in the group with GFR ≥ 60 ml/min/1.73 m2. After age and sex adjusted; it was observed that frailty was 2.5 times, probable sarcopenia 2.4 times, and malnutrition 2.7 times more in those with GFR 30–59 ml/min/1.73 m2 compared to those with GFR ≥ 60 ml/min/1.73 m2 (p < 0.05). Dementia 1.4, frailty 1.55, polypharmacy 2.0, and urinary incontinence were 1.6 times more common in those with a GFR < 30 ml/min/1.73 m2 (p < 0.05).

Conclusions

Each of the geriatric syndromes and their co-incidence are high in older CKD patients. Geriatricians and nephrologists should be aware of geriatric syndromes in older CKD patients, and they should cooperate for the management of these patients.

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Funding

No funding, grants or financial support was received.

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Authors and Affiliations

  1. Division of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey

    Pinar Soysal & Emel Caliskan Bozyel

  2. Division of Nephrology, MuÅŸ State Hospital, MuÅŸ, Turkey

    Cihan Heybeli

  3. Division of Geriatric Medicine, Manisa State Hospital, Manisa, Turkey

    Saadet Koc Okudur

  4. Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK

    Lee Smith

  5. Division of Nephrology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey

    Rumeyza Kazancioglu

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  1. Pinar Soysal
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  4. Emel Caliskan Bozyel
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  5. Lee Smith
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  6. Rumeyza Kazancioglu
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Contributions

All authors contributed to the study conception and design. Conceptualization: PS; data curation: PS; formal analysis: CH; supervision: RK; writing—original draft: PS, SKO; writing—review & editing: PS, RK, LS. The first draft of the manuscript was written by PS and SKO and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Pinar Soysal.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted (IRB approval number 97706721–900-) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Soysal, P., Heybeli, C., Koc Okudur, S. et al. Prevalence and co-incidence of geriatric syndromes according to glomerular filtration rate in older patients. Int Urol Nephrol 55, 469–476 (2023). https://doi.org/10.1007/s11255-022-03356-5

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  • DOI: https://doi.org/10.1007/s11255-022-03356-5

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