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Performance of urinary biomarkers in differentiating dysfunctional voiding in women with overactive bladder syndrome: a prospective pilot study

  • Urology - Original Paper
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Abstract

Purpose

Dysfunctional voiding (DV) in women is a common disorder that causes bladder outlet obstruction (BOO) and may aggravate overactive bladder (OAB) symptoms. The diagnosis of DV relies on clinical alertness and videourodynamic study (VUDS). In this pilot study, we aimed to explore the diagnostic potential of urinary biomarkers in women with DV.

Methods

Women who visited our institute for the management of OAB were enrolled in this prospective study. Urine samples were collected before treatment and urinary proteins were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Patients with DV and patients with normal tracings were included in the study and control group, respectively. The patients with DV were further divided into two subgroups: those with and those without detrusor overactivity (DO). VUDS parameters and urinary protein levels were compared between each subgroup.

Results

A total of 67 women were enrolled. There were 47 patients with VUDS-diagnosed DV and 20 patients in the control group. Urinary 8-OHdG level (32.65 vs. 15.59, p < 0.001) and urinary TNF-α level (1.43 vs. 0.83, p = 0.031) were significantly higher in the DV group, and urinary IL-2 level (0.29 vs. 0.83, p < 0.001) was significantly lower in the DV group. Among the DV patients, urinary PGE2 level was higher in the DO group (240.4 vs 149.6, p = 0.049).

Conclusions

In women with DV, urinary 8-OHdG level is elevated compared to women with normal VUDS. Urinary PGE2 level is elevated in patients with DV and DO. These finding suggests increased reactive-oxidative stress response and detrusor hyperactivity in DV patients. Urinary biomarkers can serve as potential non-invasive diagnostic tools in women with OAB.

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All of the data are presented in the manuscript.

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Funding

No funding was received to assist with the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Urology, National Taiwan University Hospital and College of Medicine, No. 7, Chung-Shan South Road, Taipei, 100225, Taiwan

    Po-Ming Chow

  2. Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, 707, Sec. 3, Chung-Yang Rd, Hualien, Taiwan

    Hann-Chorng Kuo

Authors
  1. Po-Ming Chow
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  2. Hann-Chorng Kuo
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Contributions

PMC: manuscript writing, data management, data analysis. HCK: project development.

Corresponding author

Correspondence to Hann-Chorng Kuo.

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Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Consent to participate

Informed consents were obtained from all individual participants included in the study.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board of the Buddhist Tzu Chi University (TCGH IRB: 107-37-A).

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Chow, PM., Kuo, HC. Performance of urinary biomarkers in differentiating dysfunctional voiding in women with overactive bladder syndrome: a prospective pilot study. Int Urol Nephrol 54, 2497–2502 (2022). https://doi.org/10.1007/s11255-022-03265-7

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  • DOI: https://doi.org/10.1007/s11255-022-03265-7

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