Abstract
Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are one of the most common morbidities in elderly men, especially in aging societies. Minimally invasive surgical treatments (MISTs) for BPH have gained an increasing interest in the current time. Rezum system is a novel MIST that uses water vapour-based convective thermal therapy to ablate prostatic tissue. According to our evaluation of the existing literature, Rezum offers a meaningful relief of LUTS with a high safety profile without compromising the sexual activity especially to those who are unfit for surgery or to those who do not desire to continue on lifelong pharmacotherapy.
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Abbreviations
- TUNA:
-
Transurethral needle ablation of the prostate
- TUMT:
-
Transurethral microwave thermotherapy
- MRI:
-
Magnetic resonance imaging
- MISTs:
-
Minimally invasive surgical treatments
- BPH:
-
Benign prostatic hyperplasia
- LUTS:
-
Lower urinary tract symptoms
- QoL:
-
Quality of life
- TURP:
-
Transurethral resection of the prostate
- BPHIII:
-
Benign prostatic hyperplasia impact index
- AUA:
-
American Urological association
- EAU:
-
European association of Urology
- EAU:
-
National institute of care excellence in UK
- PVR:
-
Post-voiding residual urine
- IIEF:
-
International index of erectile dysfunction
References
Oelke M, Kirschner-Hermanns R, Thiruchelvam N, Heesakkers J (2012) Can we identify men who will have complications from benign prostatic obstruction (BPO)?: ICI-RS 2011. Neurourol Urodyn. 31(3):322–326. https://doi.org/10.1002/nau.22222
Magistro G, Chapple CR, Elhilali M, Gilling P, McVary KT, Roehrborn CG et al. (2017) Emerging minimally invasive treatment options for male lower urinary tract symptoms[Figure presented]. Eur Urol. 72(6):986–997. https://doi.org/10.1016/j.eururo.2017.07.005
Helo S, Holland B, McVary KT (2017) Convective radiofrequency water vapor thermal therapy with rezūm system. Curr Urol Rep. 18(10):1–7
Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC et al. (2013) EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. Eur Urol 64(1):118–140
Pathak P, Helo S, McVary KT (2018) What’s new in Rezūm? Eur Urol Focus 4(1):32–35
McVary KT, Gange SN, Gittelman MC, Goldberg KA, Patel K, Shore ND et al. (2016) Erectile and ejaculatory function preserved with convective water vapor energy treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: randomized controlled study. J Sex Med. 13(6):924–933. https://doi.org/10.1016/j.jsxm.2016.03.372
Cantrill CH, Zorn KC, Elterman DS, Gonzalez RR (2019) water vapor thermal therapy for obstructive benign prostatic hyperplasia. Can J Urol. 26(1):9787–9793
Tanneru K, Jazayeri SB, Alam MU, Kumar J, Bazargani S, Kuntz G et al. (2021) An indirect comparison of newer minimally invasive treatments for benign prostatic hyperplasia: a network meta-analysis model. J Endourol. https://doi.org/10.1089/end.2020.0739
Gupta N, Rogers T, Holland B, Helo S, Dynda D, McVary KT (2018) Three-year treatment outcomes of water vapor thermal therapy compared to Doxazosin, finasteride and combination drug therapy in men with benign prostatic hyperplasia: cohort data from the MTOPS Trial. J Urol. 200(2):405–413. https://doi.org/10.1016/j.juro.2018.02.3088
Green Z, Westwood J, Somani BK (2019) What’s new in rezum: a transurethral water vapour therapy for BPH. Curr Urol Rep 20(7):1–7
Dixon C, Cedano ER, Mynderse L, Larson T. Transurethral convective water vapor as a treatment for lower urinary tract symptomatology due to benign prostatic hyperplasia using the Rezūm® system: evaluation of acute ablative capabilities in the human prostate. Res Reports Urol. 2015; 7: 13. http://www.dovepress.com/transurethral-convective-water-vapor-as-a-treatment-for-lower-urinary--peer-reviewed-article-RRU
Bhowmick P, Coad JE, Bhowmick S, Pryor JL, Larson T, De La Rosette J et al. (2004) In vitro assessment of the efficacy of thermal therapy in human benign prostatic hyperplasia. Int J Hyperth 20(4):421–439
Arezki A, Sadri I, Couture F, Schwartz R, Nguyen D-D, Zakaria AS et al. (2020) Reasons to go for Rezūm steam therapy: an effective and durable outpatient minimally invasive procedure. World J Urol. https://doi.org/10.1007/s00345-020-03457-9
McVary KT, Rogers T, Roehrborn CG (2019) Rezūm water vapor thermal therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia: 4-year results from randomized controlled study. Urology 126:171–179. https://doi.org/10.1016/j.urology.2018.12.041
Dixon C, Cedeno ER, Pacik D, Varga G, Vit V, Mynderse L (2014) Pd26–09 transurethral water vapor therapy for Bph; 1-year clinical results of the first-in-man and rezūm® I clinical trials using the rezūm® system. J Urol. 191(4):762. https://doi.org/10.1016/j.juro.2014.02.2096
Mynderse L, Hanson D, Robb R, Cedano ER, Pacik D, Varga G et al. (2014) MP71-11 rezūm® system water vapor treatment for benign prostatic hyperplasia: characterization with magnetic resonance imaging and 3D rendering. J Urol. 191(4):794. https://doi.org/10.1016/j.juro.2014.02.2170
Johnston M, Noureldin M, Abdelmotagly Y, Paramore L, Gehring T, Nedas T et al. (2020) Rezum water vapour therapy: promising early outcomes from the first UK series. BJU Int. https://doi.org/10.1111/bju.15203
Guelce D, Thomas D, Elterman D, Chughtai B. Recent advances in managing benign prostatic hyperplasia: the Rezūm System. F1000 Research. 2018;7(0):1916. https://f1000research.com/articles/7-1916/v1
Yalcin S, Tunc L. Indications, techniques, and role of new minimally invasive benign prostate hyperplasia surgical options. Türk Üroloji Dergisi/Turkish J Urol. 2020; https://www.turkishjournalofurology.com/en/indications-techniques-and-role-of-new-minimally-invasive-benign-prostate-hyperplasia-surgical-options-133644
S. Gravas , J.N. Cornu, M.J. Drake, M. Gacci CG, T.R.W. Herrmann, S. Madersbacher CM, Tikkinen KAO. EAU Guidelines Panel on Treatment of Non-neurogenic Male LUTS Guidelines: Management of Non-Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO). Eur Assoc Urol. 2018; http://uroweb.org/wp-content/uploads/EAU-Guidelines-on-the-Management-of-Non-neurogenic-Male-LUTS-2018-large-text.pdf
Roehrborn CG, Gange SN, Gittelman MC, Goldberg KA, Patel K, Shore ND et al. (2017) Convective thermal therapy: durable 2-year results of randomized controlled and prospective crossover studies for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia. J Urol. 197(6):1507–1516. https://doi.org/10.1016/j.juro.2016.12.045
Dixon C, Cedano ER, Pacik D, Vit V, Varga G, Wagrell L, et al. Two-year results after convective radiofrequency water vapor thermal therapy of symptomatic benign prostatic hyperplasia. Res Reports Urol. 2016; 8:207–16. https://www.dovepress.com/two-year-results-after-convective-radiofrequency-water-vapor-thermal-t-peer-reviewed-article-RRU
Darson MF, Alexander EE, Schiffman ZJ, Lewitton M, Light RA, Sutton MA et al. (2017) Procedural techniques and multicenter postmarket experience using minimally invasive convective radiofrequency thermal therapy with Rezūm system for treatment of lower urinary tract symptoms due to benign prostatic hyperplasia. Res Reports Urol 9:159–168
Mollengarden D, Goldberg K, Wong D, Roehrborn C (2018) Convective radiofrequency water vapor thermal therapy for benign prostatic hyperplasia: a single office experience. Prostate Cancer Prostatic Dis. 21(3):379–385. https://doi.org/10.1038/s41391-017-0022-9
Bole R, Gopalakrishna A, Kuang R, Alamiri J, Yang DY, Helo S et al. (2020) Comparative postoperative outcomes of Rezūm prostate ablation in patients with large versus small glands. J Endourol 34(7):778–781
Roehrborn CG, Barkin J, Gange SN, Shore ND, Giddens JL, Bolton DM et al. (2017) Five year results of the prospective randomized controlled prostatic urethral L.I.F.T. study. Can J Urol. 24(3):8802–8813
Ulchaker JC, Martinson M. Cost-effectiveness analysis of six therapies for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia. Clin Outcomes Res. 2017; 10:29–43. https://www.dovepress.com/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lowe-peer-reviewed-article-CEOR
Das AK, Leong JY, Roehrborn CG (2019) Office-based therapies for benign prostatic hyperplasia: a review and update. Can J Urol 26(4):2–7
Otto B, Barbieri C, Lee R, Te AE, Kaplan SA, Robinson B, et al. Incidental Prostate Cancer in Transurethral Resection of the Prostate Specimens in the Modern Era. Adv Urol. 2014; 2014: 1–4. http://www.hindawi.com/journals/au/2014/627290/
Abedi A, fallah karkan M, Allame F, Ranjbar A, Shadmehr A. Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran. Res Reports Urol. 2018 Jan; 10:1–6. https://www.dovepress.com/incidental-prostate-cancer-a-10-year-review-of-a-tertiary-center-tehra-peer-reviewed-article-RRU
Rosario DJ, Phillips JT, Chapple CR (2007) Durability and Cost-effectiveness of transurethral needle ablation of the prostate as an alternative to transurethral resection of the prostate when α-adrenergic antagonist therapy fails. J Urol. 177(3):1047–1051. https://doi.org/10.1016/j.juro.2006.10.042
Mynderse LA, Roehrborn CG, Partin AW, Preminger GM, Coté EP (2011) Results of a 5-year multicenter trial of a new generation cooled high energy transurethral microwave thermal therapy catheter for benign prostatic hyperplasia. J Urol. 185(5):1804–1810. https://doi.org/10.1016/j.juro.2010.12.054
Rassweiler J, Teber D, Kuntz R, Hofmann R (2006) Complications of transurethral resection of the prostate (TURP)—incidence, management, and prevention. Eur Urol. 50(5):969–980
Alothman A, Alharbi R, Alasker A, Ghazwani Y. Sloughing Prostatic tissue, a rare complication post Rezum therapy: a case report. Cureus. 2020. https://www.cureus.com/articles/46407-sloughing-prostatic-tissue-a-rare-complication-post-rezum-therapy-a-case-report
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Higazy, A., Osman, D. & Osman, T. Rezum: a novel minimally invasive treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia. A review article. Int Urol Nephrol 53, 1747–1756 (2021). https://doi.org/10.1007/s11255-021-02878-8
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DOI: https://doi.org/10.1007/s11255-021-02878-8