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Outcomes of death and prolonged renal insufficiency in ethylene glycol poisoned patients

  • Nephrology - Original Paper
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Abstract

Background

Despite the severity of ethylene glycol intoxication, there is a paucity of studies that analyze prognostic factors. This study aims to determine prognostic factors with impact on core outcomes like death and prolonged kidney injury (KI) in ethylene glycol poisoned patients.

Methods

We retrospectively assessed prevalence, clinical and biochemical features in one large data set from two regional hospitals from the North-East region of Romania, between January 2012 and October 2017.

Secondly, we compared prognostic factors of cases treated with dialysis plus antidote (N = 28 patients) with cases who received antidote only and supportive therapy (N = 28 patients).

Results

Of the 56 cases included, 16 deaths (28.57%) were recorded. The symptomatology at admission was more severe among patients requiring hemodialysis: a lower mean value for initial pH, lower initial alkaline reserve (AR) and higher mean values for initial serum creatinine (Cr1).

The data analysis (survivors/deceased) showed a correlation between pH, Glasgow Coma Score (GCS), and increased mortality. In addition, we found a correlation between initial mean values for pH, AR (mmol/L), Cr1 (mg/dL), and peak Cr24 (mg/dL) with outcomes of RI or death.

Conclusions

Compared with survivors, patients who died or had prolonged kidney injury were more likely to exhibit clinical signs such as coma, seizures, and acidosis. Hemodialysis and antidote should be started early and continued until acidosis is corrected.

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Funding

This study was not funded by any grant.

Author information

Author notes

  1. Gabriela Raluca Grigorasi and Ionut Nistor both authors contributed equally to the paper.

Authors and Affiliations

  1. University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania

    Gabriela Raluca Grigorasi, Ionut Nistor, Mihaela Corlade-Andrei, Luminita Voroneanu, Dimitrie Siriopol, Mugurel Apetrei, Diana Carmen Cimpoesu & Adrian Covic

  2. Emergency Department, Clinical Emergency County Hospital “St. Spiridon”, Iasi, Romania

    Gabriela Raluca Grigorasi, Mihaela Corlade-Andrei & Diana Carmen Cimpoesu

  3. Department of Nephrology, Dr CI Parhon” Hospital, Iasi, Romania

    Ionut Nistor, Luminita Voroneanu, Dimitrie Siriopol, Mugurel Apetrei & Adrian Covic

Authors
  1. Gabriela Raluca Grigorasi
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  2. Ionut Nistor
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  3. Mihaela Corlade-Andrei
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  4. Luminita Voroneanu
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  7. Diana Carmen Cimpoesu
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Corresponding authors

Correspondence to Gabriela Raluca Grigorasi or Diana Carmen Cimpoesu.

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All the authors declares that they had no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Grigorasi, G.R., Nistor, I., Corlade-Andrei, M. et al. Outcomes of death and prolonged renal insufficiency in ethylene glycol poisoned patients. Int Urol Nephrol 54, 149–155 (2022). https://doi.org/10.1007/s11255-021-02837-3

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  • DOI: https://doi.org/10.1007/s11255-021-02837-3

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