Abstract
Background
Donor/recipient size mismatching and correlation to allograft outcome remains poorly defined. This study assessed the impact of donor body weight (DBW) to recipient body weight (RBW) ratio on allograft function and survival.
Methods
A total of 898 deceased donor renal transplant recipients were included in the study. Patients were divided into quartiles depending on the ratio of DBW/RBW: Q1 (≤ 0.88), Q2 (0.89–1.00), Q3 (1.01–1.22) and Q4 (> 1.22). Donor and recipient characteristics were obtained from the national kidney transplant service database. Serum creatinine and estimated glomerular filtration rate (eGFR) at 1 and 5 years after transplant were compared.
Results
Q4 patients had a higher eGFR 1 year post-transplant (median 59.5 ml/min, IQR 46.8–76.2) compared to Q1–Q3 which had median eGFRs of 54.3, 54.8 and 55.3 ml/min, respectively (p < 0.001). At 5 years post-transplant, there were modest differences in the eGFR across the four quartiles, Q1–4 with median eGFRs of 56.9, 61.1, 61.2 and 58.6 ml/min, respectively (p = 0.02). However, there were no significant differences in 1- and 5-year allograft survival between groups.
Conclusions
In the setting of deceased donor renal transplantation, mismatching of donor to recipient weight had no impact on 5-year allograft survival, but a low DBW/RBW ratio is modestly associated with lower eGFR.
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References
Port FK, Dykstra DM, Merion RM et al (2005) Trends and results for organ donation and transplantation in the United States, 2004. Am J Transplant 5(4 Pt 2):843–849
Matas AJ, Smith JM, Skeans MA et al (2015) OPTN/SRTR 2013 annual data report: kidney. Am J Transplant 15(Suppl 2):1–34
Meier-Kriesche HU, Schold JD, Srinivas TR et al (2004) Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 4(3):378–383
Chertow GM, Milford EL, Mackenzie HS et al (1996) Antigen-independent determinants of cadaveric kidney transplant failure. JAMA 276(21):1732–1736
Bia MJ (1995) Nonimmunologic causes of late renal graft loss. Kidney Int 47(5):1470–1480
Brenner BM, Cohen RA, Milford EL (1992) In renal transplantation, one size may not fit all. J Am Soc Nephrol 3(2):162–169
Alcalde G, Escallada R, Rodrigo E et al (1997) Disproportion between kidney graft and recipient size is the main predictor of long-term proteinuria. Transplant Proc 29(1–2):127–128
El-Agroudy AE, Hassan NA, Bakr MA et al (2003) Effect of donor/recipient body weight mismatch on patient and graft outcome in living-donor kidney transplantation. Am J Nephrol 23(5):294–299
Giral M, Foucher Y, Karam G et al (2010) Kidney and recipient weight incompatibility reduces long-term graft survival. J Am Soc Nephrol 21(6):1022–1029
Goldberg RJ, Smits G, Wiseman AC (2010) Long-term impact of donor-recipient size mismatching in deceased donor kidney transplantation and in expanded criteria donor recipients. Transplantation 90(8):867–874
Dar TI, Tyagi V, Pahwa M et al (2014) A study to evaluate the effect of ratio of donor kidney weight to recipient body weight on renal graft function. Urol Ann 6(2):139–141
Gaston RS, Hudson SL, Julian BA et al (1996) Impact of donor/recipient size matching on outcomes in renal transplantation. Transplantation 61(3):383–388
Ghafari A, Etemadi J, Ardalan M (2008) Impact of donor/recipient body weight mismatch on allograft outcome in renal transplant recipients. Transplant Proc 40(1):135–136
Miles AM, Sumrani N, John S et al (1996) The effect of kidney size on cadaveric renal allograft outcome. Transplantation 61(6):894–897
Vianello A, Calconi G, Amici G et al (1996) Importance of donor/recipient body weight ratio as a cause of kidney graft loss in the short to medium term. Nephron 72(2):205–211
Lee LS, Auersvald LA, Claus EB et al (1997) Body size mismatch between donor and recipient and the development of chronic rejection in renal transplantation. Transplant Proc 29(1–2):111
Persijn GG, Smits J, De Meester J (1999) Nonimmunologic matching in renal transplantation. Transplant Proc 31(4):1772–1774
Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232(2):194–201
Kasiske BL, Umen AJ (1986) The influence of age, sex, race, and body habitus on kidney weight in humans. Arch Pathol Lab Med 110(1):55–60
Brenner BM, Milford EL (1993) Nephron underdosing: a programmed cause of chronic renal allograft failure. Am J Kidney Dis 21(5 Suppl 2):66–72
Nishimura Y, Tomikawa S, Beck Y et al (1998) Kidney graft weight as an important risk factor for long-term graft survival. Transplant Proc 30(1):107–110
Novick AC, Gephardt G, Guz B et al (1991) Long-term follow-up after partial removal of a solitary kidney. N Engl J Med 325(15):1058–1062
Meier-Kriesche HU, Arndorfer JA, Kaplan B (2002) The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death. Transplantation 73(1):70–74
Kasiske BL, Snyder JJ, Gilbertson D (2002) Inadequate donor size in cadaver kidney transplantation. J Am Soc Nephrol 13(8):2152–2159
Elbadri A, Traynor C, Veitch JT et al (2015) Factors affecting eGFR 5-year post-deceased donor renal transplant: analysis and predictive model. Ren Fail 37(3):417–423
Pourmand G, Taheri M, Mehrsai AR et al (2001) Impact of donor nephron mass on outcomes in renal transplantation. Transplant Proc 33(5):2828–2829
Han SS, Yang SH, Oh YJ et al (2011) Graft volume as the surrogate marker for nephron number affects the outcomes of living-donor kidney transplantation. Clin Transplant 25(3):E327–E335
Taherimahmoudi M, Mehrsai A, Nikoobakht M et al (2007) Does donor nephron mass have any impact on graft survival? Transplant Proc 39(4):914–916
Poggio ED, Hila S, Stephany B et al (2006) Donor kidney volume and outcomes following live donor kidney transplantation. Am J Transplant 6(3):616–624
Scott DM, Ehrmann IE, Ellis PS et al (1997) Why do some females reject males? The molecular basis for male-specific graft rejection. J Mol Med (Berl) 75(2):103–114
Tan JC, Wadia PP, Coram M et al (2008) H-Y antibody development associates with acute rejection in female patients with male kidney transplants. Transplantation 86(1):75–81
Zukowski M, Kotfis K, Biernawska J et al (2011) Donor–recipient gender mismatch affects early graft loss after kidney transplantation. Transplant Proc 43(8):2914–2916
McGee J, Magnus JH, Islam TM et al (2010) Donor–recipient gender and size mismatch affects graft success after kidney transplantation. J Am Coll Surg 210(5):718–725
Miller AJ, Kiberd BA, Alwayn IP et al (2017) Donor-recipient weight and sex mismatch and the risk of graft loss in renal transplantation. Clin J Am Soc Nephrol 12(4):669–676
Puoti F, Ricci A, Nanni-Costa A et al (2016) Organ transplantation and gender differences: a paradigmatic example of intertwining between biological and sociocultural determinants. Biol Sex Differ 7:35
Rosenberger J, Geckova AM, van Dijk JP et al (2005) Prevalence and characteristics of noncompliant behaviour and its risk factors in kidney transplant recipients. Transpl Int 18(9):1072–1078
Shibue T, Kondo K, Iwaki Y et al (1987) Effect of sex on kidney transplants. Clin Transpl 25:351–360
Panajotopoulos N, Ianhez LE, Neumann J et al (1990) Immunological tolerance in human transplantation. The possible existence of a maternal effect. Transplantation 50(3):443–445
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
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Wong, L., Counihan, A., O’Kelly, P. et al. The impact of donor and recipient weight incompatibility on renal transplant outcomes. Int Urol Nephrol 50, 551–558 (2018). https://doi.org/10.1007/s11255-017-1745-1
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DOI: https://doi.org/10.1007/s11255-017-1745-1