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High mobility group box protein-1 crossing cell borders may incite an inflammatory “tornado” in renal disease

  • Nephrology – Translational Section
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References

  1. Landsman D, Bustin M (1993) A signature for the HMG-1 box DNA-binding proteins. Bioessays 15(8):539–546

    Article  CAS  PubMed  Google Scholar 

  2. Sims GP, Rowe DC, Rietdijk ST et al (2010) HMGB1 and RAGE in inflammation and cancer. Annual Rev Immunol 28:367–388

    Article  CAS  Google Scholar 

  3. Oyama Y, Hashiguchi T, Taniguchi N et al (2010) High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Lab Invest 90(6):853–866

    Article  CAS  PubMed  Google Scholar 

  4. Rendon-Mitchell B, Ochani M, Li J et al (2003) IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism. J Immunol 170(7):3890–3897

    CAS  PubMed  Google Scholar 

  5. Wang H, Bloom O, Zhang M et al (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285(5425):248–251

    Article  CAS  PubMed  Google Scholar 

  6. Yang H, Wang H, Czura CJ et al (2005) The cytokine activity of HMGB1. J Leukoc Biol 78(1):1–8

    Article  CAS  PubMed  Google Scholar 

  7. Mantell LL, Parrish WR, Ulloa L (2006) Hmgb-1 as a therapeutic target for infectious and inflammatory disorders. Shock 25(1):4–11

    Article  CAS  PubMed  Google Scholar 

  8. Li J, Xie H, Wen T et al (2010) Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus. J Rheumatol 37(4):766–775

    Article  CAS  PubMed  Google Scholar 

  9. Yan XX, Lu L, Peng WH et al (2009) Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis 205(2):544–548

    Article  CAS  PubMed  Google Scholar 

  10. Yang H, Ochani M, Li J et al (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci USA 101(1):296–301

    Article  CAS  PubMed  Google Scholar 

  11. Kaczorowski DJ, Tsung A, Billiar TR (2009) Innate immune mechanisms in ischemia/reperfusion. Front Biosci 1:91–98

    Google Scholar 

  12. D’Agati V, Schmidt AM (2010) RAGE and the pathogenesis of chronic kidney disease. Nat Rev Nephrol 6(6):352–360

    Article  PubMed  Google Scholar 

  13. Chen G, Ward MF, Sama AE et al (2004) Extracellular HMGB1 as a proinflammatory cytokine. J Interferon Cytokine Res 24(6):329–333

    Article  PubMed  Google Scholar 

  14. Zhao J, Tramontano A, Makker SP (2007) Albumin-stimulated TGFbeta-1 in renal tubular cells is associated with activation of MAP kinase. Int Urol Nephrol 39(4):1265–1271

    Article  CAS  PubMed  Google Scholar 

  15. Fiuza C, Bustin M, Talwar S et al (2003) Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood 101(7):2652–2660

    Article  CAS  PubMed  Google Scholar 

  16. Oh YJ, Youn JH, Ji Y et al (2009) HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism. J Immunol 182(9):5800–5809

    Article  CAS  PubMed  Google Scholar 

  17. Hruby Z, Kopec W, Szewczyk Z (1985) Activity of circulating monocytes in patients with chronic glomerulonephritis. Int Urol Nephrol 17(4):379–387

    Article  CAS  PubMed  Google Scholar 

  18. Hruby Z, Lowry RP, Forbes RD et al (1988) Immune mechanisms and molecular mediators of glomerular injury in experimental nephritis. Summary of current results and continuing studies. Int Urol Nephrol 20(5):513–517

    Article  CAS  PubMed  Google Scholar 

  19. Jiang C, Ting AT, Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391(6662):82–86

    Article  CAS  PubMed  Google Scholar 

  20. Lee JH, Woo JH, Woo SU et al (2008) The 15-deoxy-delta 12, 14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. J Immunol 181(12):8642–8649

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

PRM is funded by Sonderforschungsbereich (SFB) 854, project 1 and ME1365/7-1.

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Correspondence to P. R. Mertens.

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Shpacovitch, V., Mertens, P.R. High mobility group box protein-1 crossing cell borders may incite an inflammatory “tornado” in renal disease. Int Urol Nephrol 42, 847–850 (2010). https://doi.org/10.1007/s11255-010-9829-1

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  • DOI: https://doi.org/10.1007/s11255-010-9829-1

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