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Unexpected, severe central nerve system toxicity of ofloxacine: report of two cases

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Abstract

Central nerve system toxicity of fluoroquinolones is well known but nearly always benign. Old age, concomittant central nerve system disease, drug interactions and/ or partial or total loss of renal function are the major risk factors. Although, in literature there is very limited number of severe central nerve system toxicity cases related to fluoroqinolones, prompt realization is vital as the only therapy is discontinuation of the drug. In this article, two cases of acute central nerve system toxicity of ofloxacin with an unexpected severity are described.

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Authors and Affiliations

  1. Urology Department, Gulhane Military Medical Faculty, Ankara, Turkey

    E. Oguz Guven & Mete Kilciler

  2. Beysukent Planlamacilar Sitesi 150. sok / No:36, Cayyolu / Ankara, Turkey

    E. Oguz Guven

  3. Urology Department, Ataturk Research Hospital, Ankara, Turkey

    Derya Balbay

Authors
  1. E. Oguz Guven
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  2. Derya Balbay
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  3. Mete Kilciler
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Correspondence to E. Oguz Guven.

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Guven, E.O., Balbay, D. & Kilciler, M. Unexpected, severe central nerve system toxicity of ofloxacine: report of two cases. Int Urol Nephrol 39, 647–649 (2007). https://doi.org/10.1007/s11255-006-0068-4

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  • DOI: https://doi.org/10.1007/s11255-006-0068-4

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