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Metabolic status of lactating cows given a hepatoprotectant and different feed energy sources

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Abstract

The present study aimed to evaluate the effects of hepatoprotective agents added to diets containing different energy sources on the metabolic status of lactating dairy cows in confinement. Sixteen Holstein × Gir crossbred midlactation cows with a body weight of 553 ± 85 kg were included in this feeding trial. These animals were arranged in a 4 × 4 Latin square experimental design. A 2 × 2 factorial arrangement was employed in this feeding experiment. Experimental treatments consisted of the administration of diets supplemented with a hepatoprotectant and diets without hepatoprotectant. These diets contained varying amounts of ground corn or citrus pulp as energy sources. Serum markers for energy metabolism and proteins were evaluated and liver enzymes were measured. Blood samples were collected in the morning before (0 h) and 4 h after the animals were fed these diets. There was no interaction between the hepatoprotective agent and the dietary energy sources for the metabolic status variables. Ground corn as an energy source yielded higher serum concentrations of glucose, HDL (high-density lipoprotein) cholesterol, and globulins, whereas b-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), total cholesterol, albumin, and aspartate aminotransferase (AST) yielded the highest concentrations in diets containing citrus pulp. There was interaction between time and hepatoprotective agent in serum LDL (low-density lipoprotein) cholesterol concentration. The present study shows that ground corn diets increased the synthesis of glucogenic nutrients, whereas citrus pulp used as an energy source altered the lipid status of lactating cows. The hepatoprotective agent increased postprandial serum LDL cholesterol levels.

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Funding

We are grateful to Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; project 140767/2017-7) and Agência Paulista de Tecnologia dos Agronegócios (APTA) for supporting this study.

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Authors and Affiliations

  1. Centro de Ciências Agrárias, Universidade Federal da Paraíba, Rodovia BR 079 Km 12, Areia, Paraíba, Brazil

    Jessyca Karen Pinheiro, Severino Gonzaga Neto & José Maria Cesar Neto

  2. Polo Regional Alta Mogiana, Agência Paulista de Tecnologia dos Agronegócios, Avenida Rui Barbosa, Colina, Sao Paulo, Brazil

    Ricardo Dias Signoretti

  3. Faculdade de Medicina, Universidade Federal de Juiz de Fora, Rua Espírito Santo 993, Juiz de Fora, Minas Gerais, Brazil

    Lara Toledo Henriques

  4. Centro de Saúde e Tecnologia Rural, Universidade Federal de Campina Grande, Avenida Universitária, Patos, Paraíba, Brazil

    Jovanna Karine Pinheiro

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  1. Jessyca Karen Pinheiro
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  2. Severino Gonzaga Neto
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  3. Ricardo Dias Signoretti
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  4. Lara Toledo Henriques
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  5. José Maria Cesar Neto
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  6. Jovanna Karine Pinheiro
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Correspondence to Jessyca Karen Pinheiro.

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This research project was approved by the Animal Ethics Committee (AEC) of the Federal University of Paraíba (UFPB, Brazil), reference number 4117200519. All the authors consent to participate in publication.

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Pinheiro, J.K., Gonzaga Neto, S., Signoretti, R.D. et al. Metabolic status of lactating cows given a hepatoprotectant and different feed energy sources. Trop Anim Health Prod 53, 184 (2021). https://doi.org/10.1007/s11250-021-02631-4

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