Abstract
The objective of the present study was to investigate the comparative efficacy of recommended dose of selected anticoccidial drugs Salinomycin and Dinitolmide, while Cocciban at three dose levels on the hematobiochemical, fecal parameters and histopathology of broilers. For this purpose, 420-day-old commercial male broiler chicks were randomly divided into 7 treatment groups with 10 replications of 6 birds each and reared in battery brooders up to 42 days of age. Groups were designated as uninfected unmedicated (T1), infected unmedicated (T2), Cocciban 500 g/ton and infected (T3), Cocciban 750 g/ton and infected (T4), Cocciban 1000 g/ton and infected (T5), Salinomycin 500 g/ton and infected (T6), and Dinitolmide and infected (T7). Groups T2, T3, T4, T5, T6, and T7 were experimentally infected at 21-day-old by 50,000 oocysts of Eimeria species. The mean fecal, lesion scores and oocyst per gram of feces were significantly (p < 0.05) highest in infected unmedicated group, while lowest in the herbal Cocciban 1000 g/ton group than all other infected medicated groups. The hematological studies revealed a reduction in TEC, Hb, and PCV from 0 to 5th day of P.I. in all infected groups except healthy control group. The birds of all the infected groups improved in the values of TEC, Hb, PCV, blood glucose, and total serum protein on 7th day of P.I., but, the improvement was significantly (p < 0.05) better in herbal Cocciban 1000 g/ton treated birds than all other infected groups. Whereas, the TWBC counts were raised from 0 to 7th day of P.I. in all the infected groups compared to healthy control and no significant (p < 0.05) difference was observed in between the infected groups. The histopathological changes consisting of desquamation of epithelial cells, cellular infiltration, hemorrhages, edema, fibrous tissue proliferation, and developing stages of E. tenella at various depths of cecal wall were higher in all the infected groups when compared to Cocciban 1000 g/ton group.
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References
Basith Abdul, S., Rajavelu, G. and Murali Manohar, B. 1998. Biochemical studies in experimental Eimeria necatrix infection in chickens. Indian VetrinaryJournal, 75, 876-878.
Bayer, R. C, Chwan, C.B. and Bryan, T.A. 1976. Caecal mucosal response to coccidiosis in growing chicken. Poultry Science, 55, 1020-1025.
Biester, H.E. and Schwarte, L.H. 1969. Diseases of Poultry. 5th Edition, Oxford and IBH Publishing Company. New Delhi pp.1073.
Chandrakesan, P., Muralidharan, K., Dinesh Kumar, V., Gurusamy, P., Haridrishnan, T.J. and Natarajan Rani, K.S.V. 2009. Efficacy of a herbal complex against caecal coccidiosis in broiler chickens. Veterinarski Athiv, 79(2), 199-203.
Edds, G.T. and Simpson, C.F. 1976. Caecal coccidiosis in poultry as affected by prior exposure to aflatoxin B1. American Journal of Veterinary Research, 37, 65-68.
Freitas, F.L.C., Almeida, K.S., Machado, R.Z. and Machado, C.R. 2008. Lipid and glucose metabolism of broilers (Gallus domesticus) experimentally infected with Eimeria acervulina oocysts. Brazilian Journal of Poultry Science, 10(3), 157-162.
Gill, B.S. and Ray, H.N. 1957. Life cycle and cytology of E. tenella Railliet and Lucet, 1891 with notes on symptomatology and pathology of the infection. Proceedings of Zoological Society of Calcutta. pp 357-383.
Haghighi-Khoshkhoo, P., Shapor-Reza Shojaei, S., Akbari-Azad, G. and Roohi, M. 2009. Comparative investigation of efficacy of two sulfonamides on broiler coccidiosis infected by Iranian Eimeria spp in Iran. 2nd Mediterranean Summit of WPSA 79-82.
Hirani, N.D., Hasnani, J.J., Joshiand, R.S. and Prajapati, K.S. 2006. Haemato-biochemical studies on fowl coccidiosis in layer birds. Journal of Parasitic Diseases, 30(1), 85-88.
Jaipukar, S.G., Deshpande, P.D., Narladkar, B.W., Rajukar, S.R. and Kulkarni, G.B. 2004. Caecal cocccidiosis in broiler chicks: Haematological, pathological changes during treatment with herbal diarrhoeals. Journal of Veterinary Parasitology, 18, 135-38.
Johnson, J. and Ried, W.M. 1970. Anticoccidial agents. Lesion scoring techniques in battery and floor pen experiments with chicken. Experimental Parasitology, 38, 30-36.
Kurkure, N.V., Kolte, S.W., Bhandarkar, A.H. and Kalorey, D.R. 2006. Evaluation of herbal coccidiostat ‘Coxynil’ in broiler. Indian Journal of Experimental Biology, 44, 740-744.
Morehouse, N.F. and Baron, R.R. 1970. Coccidiosis: evaluation of coccidiostats by mortality, weight gains and fecal scores. Exp. Parasitol, 28(1), 25-9.
National Research Council. 1994. Nutrient Requirement of Poultry. 9th rev. ed. National press, Washington D C.
Pansare, P.A. and Lonkar. P.S. 2009. A herbal coccidiostat on pathology of coccidiosis in broilers – Effect of Coxynil. Poultry industry, Technical articles, health.
Shirley, M.W., Smith, A.L. and Tomley, F.M. 2005. The biology of avian Eimeria with an emphasis on their control by vaccination. Advances in Parasitology, 60, 285-330.
Singala, L.D., Pangasa, A. and Juyal, P.D. 2007. Caecal coccidiosis: efficacy of ayurvedic and allopathic coccidiostats in immunomodulated broiler Chicks. Proceedings of the 12th international conference of the association of institutions of tropical veterinary medicine.
Singh, V.S., Palod, J., Shukla, S.K. and Shukla, P.K. 2008. Influence of a herbal anticoccidials on growth, parasitological, hematological parameters and carcass traits of broilers experimentally infected with mixed field isolates of Eimeria species. Indian journal Animal Sciences, 78(10), 1057-1062.
Udaya Kumar, M., Padmavathi, P. and Ramesh, A.J. 1995. Effect of Aflatoxin B1 and Eimeria tenella infection on Mortality and Growth in Broiler Chicks. Indian Veterinary Journal, 1141-1144.
Udaya Kumar, M. and Padmavathi, P. 2000. Interaction of aflatoxin B1 and Eimeria tenella infection in broiler chickens. Journal of Veterinary Parasitology, 14(1), 39-43.
Yadav, A. and Gupta, S.K. 2001. Study of resistance against some ionophores in Eimeria tenella field isolates. Veterinary parasitology, 102(1-2), 69-75.
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The authors are thankful to Indian Herbs, Hyderabad, India, for funding the research.
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B, S., Preetam, V.C., Srinivas, G. et al. Effect of Cocciban herbal coccidiostats on hematobiochemical, fecal parameters and cecal histopathology of broiler chicken. Trop Anim Health Prod 51, 1375–1381 (2019). https://doi.org/10.1007/s11250-019-01831-3
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DOI: https://doi.org/10.1007/s11250-019-01831-3