Abstract
Arterial stent deployment by balloon or self-expandable structure introduces shear forces and radial forces that can damage or remove the endothelial cell layer. These factors can subsequently cause failure by restenosis or endothelial leaks. These conditions can be exacerbated by pulsatile blood flow and arterial asymmetry, which can cause migration or displacement. In mechanical or finite-element models which attempt to explain this motion, friction between the stent materials and endothelial cells is eclipsed by pressure, or assumptions that cells are moved along with the stent. During device deployment or migration, some relative motion between stent materials and endothelial cells occurs. This study aims to quantify friction between a polished glass pin and a single layer of arterial endothelial cells, and include observations of cell damage in an attempt to better understand the biological response to tribological stresses. Measured friction coefficient values were on the order of μ = 0.03–0.06.
Similar content being viewed by others
References
Ho, S.P., Nakabayashi, N., Iwasaki, Y., Boland, T., Laberge, M.: Frictional properties of Poly(Mpc-Co-Bma) phospholipid polymer for catheter applications. Biomaterials 24(28), 5121–5129 (2003)
Lim, I.: Biocompatibility of stent materials. MIT Undergrad. Res. J. 11(Fall 2004), 33–37 (2004)
Costa, K.D., Sim, A.J., Yin, F.C.P.: Non-hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. J. Biomech. Eng. Trans. Asme 128(2), 176–184 (2006)
Volodos, S.M., Sayers, R.D., Gostelow, J.P., Bell, P.R.F.: An investigation into the cause of distal endoleaks: role of displacement force on the distal end of a stent-graft. J. Endovas. Ther 12(1), 115–120 (2005)
Liffman, K., Sutalo, I.D., Lawrence-Brown, M.M.D., Semmens, J.B., Aldham, B.: Movement and dislocation of modular stent-grafts due to pulsatile flow and the pressure difference between the stent-graft and the aneurysm sac. J. Endovas. Ther 13(1), 51–61 (2006)
Resch, T., Malina, M., Lindblad, B., Malina, J., Brunkwall, J., Ivancev, K.: The impact of stent design on proximal stentgGraft fixation in the abdominal aorta: an experimental study. Eur. J. Vasc. Endovasc. Surg. 20(2), 190–195 (2000)
Jedwab, M.R., Clerc, C.O.: A study of the geometrical and mechanical-properties of a self-expanding metallic stent theory and experiment. J. Appl. Biomat. 4(1), 77–85 (1993)
Morris, L., Delassus, P., Walsh, M., Mcgloughlin, T.: A mathematical model to predict the in vivo pulsatile drag forces acting on bifurcated stent grafts used in endovascular treatment of abdominal aortic aneurysms (Aaa). J. Biomech 37(7), 1087–1095 (2004)
Li, Z., Kleinstreuer, C.: Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model. J. Biomech 39(12), 2264–2273 (2006)
Li, Z., Kleinstreuer, C., Farber, M.: Computational analysis of biomechanical contributors to endovascular graft failure. Biomech. Model Mechanobiol. 4(4), 221–234 (2005)
Walke, W., Paszenda, Z., Filipiak, J.: Experimental and numerical biomechanical analysis of vascular stent. J. Mater. Process. Technol. 164, 1263–1268 (2005)
Wang, R., Ravi-Chandar, K.: Mechanical response of a metallic aortic stent - Part I: Pressure-diameter relationship. J. Appl. Mech. Trans. Asme 71(5), 697–705 (2004)
Wang, R., Ravi-Chandar, K.: Mechanical response of a metallic aortic stent - Part Ii: A beam-on-elastic foundation model. J. Appl. Mech. Trans. Asme 71(5), 706–712 (2004)
Laroche, D., Delorme, S., Anderson, T., Diraddo, R.: Computer prediction of friction in balloon angioplasty and stent implantation. Biomed. Simul., Proc. 4072, 1–8 (2006)
Holzapfel, G., Stadler, M., Gasser, T.C.: Changes in the mechanical environment of stenotic arteries during interaction with stents: computational assessment of parametric stent designs. J. Biomech. Eng. Trans. Asme 127(1), 166–180 (2005)
Fisher, A.B., Chien, S., Barakat, A.I., Nerem, R.M.: Endothelial cellular response to altered shear stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 281(3), L529–L533 (2001)
Sato, H., Katano, M., Takigawa, T., Masuda, T.: Estimation for the elasticity of vascular endothelial cells on the basis of atomic force microscopy and Young’s modulus of gelatin gels. Polym. Bull. 47(3–4), 375–381 (2001)
Sato, M., Nagayama, K., Kataoka, N., Sasaki, M., Hane, K.: Local mechanical properties measured by atomic force microscopy for cultured bovine endothelial cells exposed to shear stress. J. Biomech. 33(1), 127–135 (2000)
Yeh, H.I., Lu, S.K., Tian, T.Y., Hong, R.C., Lee, W.H., Tsai, C.H.: Comparison of endothelial cells grown on different stent materials. J. Biomed. Mater. Res. A 76A(4), 835–841 (2006)
Rennie, A.C., Dickrell, P.L., Sawyer, W.G.: Friction coefficient of soft contact lenses: measurements and modeling. Tribol. Lett. 18(4), 499–504 (2005)
Keselowsky, B.G., Collard, D.M., Garcia, A.J.: Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding. Biomaterials 25(28), 5947–5954 (2004)
Keselowsky, B.G., Garcia, A.J.: Quantitative methods for analysis of integrin binding and focal adhesion formation on biomaterial surfaces. Biomaterials 26(4), 413–418 (2005)
Keselowsky, B.G., Wang, L., Schwartz, Z., Garcia, A.J., Boyan, B.D.: Integrin alpha(5) controls osteoblastic proliferation and differentiation responses to titanium substrates presenting different roughness characteristics in a roughness independent manner. J. Biomed. Mater. Res. A 80A(3), 700–710 (2007)
Butcher, J.T., Tressel, S., Johnson, T., Turner, D., Sorescu, G., Jo, H., Nerem, R.M.: Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences - influence of shear stress. Arterioscler. Thromb. Vasc. Biol. 26(1), 69–77 (2006)
Galbraith, C.G., Skalak, R., Chien, S.: Shear stress induces spatial reorganization of the endothelial cell cytoskeleton. Cell Motil. Cytoskeleton 40(4), 317–330 (1998)
Mohan, I.V., Harris, P.L., Van Marrewijk, C.J., Laheij, R.J., How, T.V.: Factors and forces influencing stent-graft migration after endovascular aortic aneurysm repair. J. Endovasc. Ther. 9, 748–755 (2002)
Ratner B.D., Bryant S.J.: Biomaterials: where we have been and where we are going. Annu. Rev. Biomed. Eng. 6, 41–75 (2004)
Brash J.L.: Protein adsorption at the solid-solution interface in relation to blood-material interactions. In: Horbett T.A., Brash J.L. (eds) Proteins at Interfaces, pp. 490–506. American Chemical Society, Washington, DC (1987)
Andrade, J.D., Hlady, V.V.: Protein adsorption and materials biocompatibility: a tutorial review and suggested hypotheses. Adv. Polym. Sci. 79, 1–63 (1986)
Keselowsky, B.G., Collard, D.M., Garcia, A.J.: Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc. Natl. Acad. Sci. U.S.A 102(17), 5953–5957 (2005)
Keselowsky, B.G., Collard, D.M., Garcia, A.J.: Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J. Biomed. Mater. Res. A 66A(2), 247–259 (2003)
Acknowledgements
The authors would like to acknowledge very helpful conversations regarding testing procedures and cell culturing with Prof. Roger Tran-Son-Tay, Prof. Malisa Sarntinoranont, and Jessica Cobb at the University of Florida.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dunn, A.C., Zaveri, T.D., Keselowsky, B.G. et al. Macroscopic Friction Coefficient Measurements on Living Endothelial Cells. Tribol Lett 27, 233–238 (2007). https://doi.org/10.1007/s11249-007-9230-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11249-007-9230-0