Skip to main content
SpringerLink
Log in

Introducing an Electrochemical Sensor Based on Two Layers of Ag Nanoparticles Decorated Graphene for Rapid Determination of Methadone in Human Blood Serum

  • Original Paper
  • Published:
Topics in Catalysis Aims and scope Submit manuscript

Abstract

In the present study, a highly efficient electrochemical sensor for methadone measurement through the use of a glassy carbon electrode modified with two layers of graphene/Ag nanoparticles ((Gr/AgNPs)2/GCE) nanocomposite is introduced. The morphological, elemental and electrochemical properties of the as-prepared nanocomposite were evaluated by scanning electron microscopy, energy dispersive spectroscopy. The influence of different experimental parameters such as pH and scan rate on the voltammetric response of methadone was also addressed. Exhibiting a peak potential at + 0.79 V (vs. Ag/AgCl), the as-prepared electrode manifested an improvement in its catalytic activity toward methadone oxidation. Under optimal conditions, the developed sensor exhibited an excellent response toward methadone in the concentration range of 1.0–200.0 µM with a detection limit of 0.12 µM. Moreover, the proposed electrode offered superior selectivity for methadone reflecting its efficiency for the real samples such as human blood serum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Ribeiro A (2019) Anal Bioanal Chem 411:2177

    Article  CAS  PubMed  Google Scholar 

  2. Dole VP, Nyswander M (1965) J Am Med Assoc 193:646

    Article  CAS  Google Scholar 

  3. Eap CB, Buclin T, Baumann P (2002) Clin Pharmacokinet 41:1153

    Article  CAS  PubMed  Google Scholar 

  4. Cooper JR (1992) J Am Med Assoc 267:281

    Article  CAS  Google Scholar 

  5. Zweben JE, Payte JT (1990) West J Med 152:588

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Marsh A, Evans MB, Strang J (1995) J Pharm Biomed Anal 13:829

    Article  CAS  PubMed  Google Scholar 

  7. ElSohly MA, Feng S, Murphy TP (2001) J Anal Toxicol 25:40

    Article  CAS  PubMed  Google Scholar 

  8. Han B, Du Y, Wang E (2008) Microchem J 89:137

    Article  CAS  Google Scholar 

  9. Montero R, Gallego M, Valcárcel M (1990) Anal Chim Acta 234:433

    Article  CAS  Google Scholar 

  10. Somaini L, Saracino MA, Marcheselli C, Zanchini S, Gerra G, Raggi MA (2011) Anal Chim Acta 702:280

    Article  CAS  PubMed  Google Scholar 

  11. Taheri S, Jalali F, Fattahi N, Jalili R, Bahrami G (2015) J Sep Sci 38:3545

    Article  CAS  PubMed  Google Scholar 

  12. Diong SH, Yusoff NSM, Sim MS, Aziddin RER, Chik Z, Rajan P, Rusdi Abdul R, Chemi N, Mohamed Z (2014) J Anal Toxicol 38:660

    Article  CAS  PubMed  Google Scholar 

  13. Meng L, Zhang W, Meng P, Zhu B, Zheng K (2015) J Chromatogr B 989:46

    Article  CAS  Google Scholar 

  14. Schumacher S, Seitz H (2016) J Immunol Methods 436:34

    Article  CAS  PubMed  Google Scholar 

  15. Barroso M, Dias M, Vieira DN, LóPez-Rivadulla M, Queiroz JA (2010) Biomed Chromatogr 24:1240

    Article  CAS  PubMed  Google Scholar 

  16. Karimi-Maleh H, Karimi F, Alizadeh M, Sanati AL (2020) Chem Rec 20:682

    Article  CAS  PubMed  Google Scholar 

  17. Karimi-Maleh H, Karimi F, Malekmohammadi S, Zakariae N, Esmaeili R, Rostamnia S, Yola ML, Atar N, Movagharnezhad S, Rajendran S, Razmjou A, Orooji Y, Agarwal S, Gupta VK (2020) J Mol Liq 310:113185

    Article  CAS  Google Scholar 

  18. Karimi-Maleh H, Cellat K, Arıkan K, Savk A, Karimi F, Şen F (2020) Mater Chem Phys 250:23042

    Article  CAS  Google Scholar 

  19. Afkhami A, Soltani-Felehgari F, Madrakian T (2014) Talanta 128:203

    Article  CAS  PubMed  Google Scholar 

  20. Alipour E, Majidi MR, Hoseindokht O (2015) J Chin Chem Soc 62:461

    Article  CAS  Google Scholar 

  21. Soleimani M, Afshar MG, Ganjali MR (2013) Sens Lett 11:1983

    Article  CAS  Google Scholar 

  22. Karim-Nezhad G, Khorablou Z (2017) Anal Bioanal Electrochem 9:689

    CAS  Google Scholar 

  23. Karimi-Maleh H, Karimi F, Orooji Y, Mansouri G, Razmjou A, Aygun A, Sen F (2020) Sci Rep 10:11699

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Karimi-Maleh H, Alizadeh M, Orooji Y, Karimi F, Baghayeri M, Rouhi J, Tajik S, Beitollahi H, Agarwal S, Gupta VK, Rajendran S, Rostamnia S, Fu L, Saberi-Movahed F, Malekmohammadi S (2021) Ind Eng Chem Res 60:816

    Article  CAS  Google Scholar 

  25. Karimi-Maleh H, Yola ML, Atar N, Orooji Y, Karimi F, Kumar PS, Rouhi J, Baghayeri M (2021) J Colloid Interface Sci 592:174

    Article  CAS  PubMed  Google Scholar 

  26. Nodehi M, Baghayeri M, Veisi H (2021) Talanta 230:122288

    Article  CAS  PubMed  Google Scholar 

  27. Akça A, Karaman O, Karaman C (2021) ECS J Solid State Sci 10:041003

    CAS  Google Scholar 

  28. Karaman C, Karaman O, Atar N, Yola ML (2021) Electrochim Acta 380:138262

    Article  CAS  Google Scholar 

  29. Karaman C, Karaman O, Atar N, Yola ML (2021) Microchim Acta 188:182

    Article  CAS  Google Scholar 

  30. Karimi-Maleh H, Orooji Y, Karimi F, Alizadeh M, Baghayeri M, Rouhi J, Tajik S, Beitollahi H, Agarwal S, Gupta VK, Rajendran S, Ayati A, Fu L, Sanati AL, Tanhaei B, Sen F, Asrami PN, Al-Othman A (2021) Biosens Bioelectron 184:113252

    Article  CAS  PubMed  Google Scholar 

  31. Karimi-Maleh H, Arotiba OA (2020) J Colloid Interface Sci 560:208

    Article  CAS  PubMed  Google Scholar 

  32. Li Y, Li K, Song G, Liu J, Zhang K, Ye B (2013) Sens Actuators B 182:401

    Article  CAS  Google Scholar 

  33. Karaman C (2021) Electroanalysis 33:1356

    Article  CAS  Google Scholar 

  34. Pruneanu S, Biris AR, Pogacean F, Lazar DM, Ardelean S, Watanabe F, Dervishi E, Biris AS (2012) ChemPhysChem 13:3632

    Article  CAS  PubMed  Google Scholar 

  35. Baghayeri M, Ghanei-Motlagh M, Tayebee R, Fayazi M, Narenji F (2020) Anal Chim Acta 1099:60

    Article  CAS  PubMed  Google Scholar 

  36. Liu A, Yuan M, Zhao M, Lu C, Zhao T, Li P, Tang W (2014) J Alloys Compd 586:99

    Article  CAS  Google Scholar 

  37. Zhang S, Shao Y, Liao HG, Liu J, Aksay IA, Yin G, Lin Y (2011) Chem Mater 23:1079

    Article  CAS  Google Scholar 

  38. Liu A, Xu T, Ren Q, Yuan M, Dong W, Tang W (2012) Electrochem Commun 25:74

    Article  CAS  Google Scholar 

  39. Shi Q, Mu S (2012) J Power Sources 203:48

    Article  CAS  Google Scholar 

  40. AlAqad KM, Abulkibash AM, Al Hamouz OCS, Saleh TA (2017) Chem Data Collect 11–12:168

    Article  Google Scholar 

  41. Golinelli DLC, Machado SAS, Cesarino I (2017) Electroanalysis 29:1014

    Article  CAS  Google Scholar 

  42. Noor AM, Shahid MM, Rameshkumar P, Huang NM (2016) Microchim Acta 183:911

    Article  CAS  Google Scholar 

  43. Otari SV, Kumar M, Anwar MZ, Thorat ND, Patel SKS, Lee D, Lee JH, Lee JK, Kang YC, Zhang L (2017) Sci Rep 7:1

    Article  CAS  Google Scholar 

  44. Jia M, Wang T, Liang F, Hu J (2012) Electroanalysis 24:1864

    Article  CAS  Google Scholar 

  45. Togashi T, Saito K, Matsuda Y, Sato I, Kon H, Uruma K, Ishizaki M, Kanaizuka K, Sakamoto M, Ohya N, Kurihara M (2014) J Nanosci Nanotechnol 14:6022

    Article  CAS  PubMed  Google Scholar 

  46. MacHmudah S, Sato T, Wahyudiono, Sasaki M, Goto M (2012) High Pressure Res 32:60

    Article  CAS  Google Scholar 

  47. Pal A, Shah S, Devi S (2009) Mater Chem Phys 114:530

    Article  CAS  Google Scholar 

  48. Gudikandula K, Charya Maringanti S (2016) J Exp Nanosci 11:714

    Article  CAS  Google Scholar 

  49. Baghayeri M, Amiri A, Farhadi S (2016) Sens Actuators B 225:354

    Article  CAS  Google Scholar 

  50. Hu Y, Jin J, Wu P, Zhang H, Cai C (2010) Electrochim Acta 56:491

    Article  CAS  Google Scholar 

  51. Pariente F, Lorenzo E, Tobalina F, Abruña HD (1995) Anal Chem 67:3936

    Article  CAS  Google Scholar 

  52. Alberti G, Palombari R, Pierri F (1997) Solid State Ion 97:359

    Article  CAS  Google Scholar 

  53. Yang N, Wan Q, Yu J (2005) Sens Actuators B 110:246

    Article  CAS  Google Scholar 

  54. Nodehi M, Baghayeri M, Behazin R, Veisi H (2021) Microchem J 162:105825

    Article  CAS  Google Scholar 

  55. Amiri-Aref M, Raoof JB, Ojani R (2013) Colloids Surf B Biointerfaces 109:287

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Hakim Sabzevari University, PO Box 397, Sabzevar, Iran

    Mehdi Baghayeri & Vida Ebrahimi

  2. Research Institute of Police Science and Social Studies, PO Box 19395-6516, Tehran, Iran

    Samaneh Nabavi

  3. Young Researchers and Elite Club, Sabzevar Branch, Islamic Azad University, Sabzevar, Iran

    Ehteram Hasheminejad

Authors
  1. Mehdi Baghayeri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samaneh Nabavi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ehteram Hasheminejad
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vida Ebrahimi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MB: The first corresponding author; proposing of this study; Methodology, writing-original draft preparation, SN: The second corresponding author; reviewing and editing, EH: Investigation, synthesized and characterized the nanocomposite, VE: student and performed the electrochemical experiments.

Corresponding authors

Correspondence to Mehdi Baghayeri or Samaneh Nabavi.

Ethics declarations

Conflict of interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baghayeri, M., Nabavi, S., Hasheminejad, E. et al. Introducing an Electrochemical Sensor Based on Two Layers of Ag Nanoparticles Decorated Graphene for Rapid Determination of Methadone in Human Blood Serum. Top Catal 65, 623–632 (2022). https://doi.org/10.1007/s11244-021-01483-4

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11244-021-01483-4

Keywords

Search

Navigation