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Systematic analysis of the maize cyclophilin gene family reveals ZmCYP15 involved in abiotic stress response

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Abstract

Cyclophilins (CYPs) belong to the immunophilin superfamily, having the peptidyl prolyl cis/trans isomerase activity that can catalyze the cis/trans isomerisation process of proline residues. Previous studies have shown their importance in plants, but no comprehensive analysis of maize CYP family has been reported. In the present study, a whole-genome-wide analysis of maize CYP family was performed and 39 ZmCYP genes (ZmCYP1 to ZmCYP39) were identified from maize genome, which were unequally distributed on maize ten chromosomes. Phylogenetic analysis revealed a weak relationship among these ZmCYP genes. Furthermore, their gene structure and motif patterns also displayed variant within the gene family. Four segmental and one tandem duplicated gene pairs were found from 39 ZmCYP genes, respectively, indicating their roles in the expansion of maize CYP family. Expression analysis of 39 ZmCYP genes in maize tissues showed their differential tissue specific expression patterns. Quantitative real-time PCR analysis of 19 selected ZmCYP genes under salinity stress indicated their stress-inducible expression profile. Heterologous expression of ZmCYP15 in E. coli enhanced tolerance against abiotic stress. Subcellular localization analysis indicated ZmCYP15 was located in nucleus and cytoplasm. Our study describes the importance of the maize CYP gene family in stress response, and provides a reference for future study and application for maize genetic improvement.

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Acknowledgements

We thank all the members of the Key Laboratory of Crop Biology of Anhui Province for their assistance in this study. This research work was supported by National Natural Science Foundation (31571685) and Major projects of national natural science fund (91435110). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

QQW, YW and XYL conceived and designed this research. QQW, WBC and YW performed the experiment. QQW, NNS, JW and LMC analyzed the data. QQW, YW, HYJ and XYL contributed reagents/materials/analysis tools. QQW, YW and XYL wrote the manuscript. HYJ and XYL revised the manuscript.

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    1. Key Laboratory of Crop Biology of Anhui Province, Anhui Agricultural University, Hefei, China

      Qianqian Wang, Yu Wang, Wenbo Chai, Nannan Song, Jing Wang, Limin Cao, Haiyang Jiang & Xiaoyu Li

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    Qianqian Wang and Yu Wang have contributed equally to this work.

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    Wang, Q., Wang, Y., Chai, W. et al. Systematic analysis of the maize cyclophilin gene family reveals ZmCYP15 involved in abiotic stress response. Plant Cell Tiss Organ Cult 128, 543–561 (2017). https://doi.org/10.1007/s11240-016-1132-0

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