Abstract
Metabolites are reliable biomarkers for many diseases. However, their role in acute ischemic stroke (AIS) pathogenesis is not well understood. In this systematic review we aim to evaluate the current literature on the presence of metabolites in thrombi retrieved by mechanical thrombectomy from AIS patients. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guidelines, we searched OVID Medline, PubMed, OVID Embase, Scopus, and Web of Science until July 13, 2022. Metabolites lists were extracted, and pathway analysis was performed in MetaboAnalyst database. Four articles listing metabolites were included in this systematic review. D-Glucose, diacylglycerol, phytosphingosine, galabiosylceramide, glucosylceramide and 4-hydroxynonenal were reported to be associated with clots. Metabolomics data analysis showed that glycolysis, lactose, and sphingolipid metabolism pathways were enriched. In conclusion, results of the present study show that the thrombi niche has a glycolytic phenotype. Future studies should work to better understand the metabolic properties of AIS thrombi.
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Acknowledgements
Research reported in this publication was in part supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number NS105853. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Arul, S., Ghozy, S., Mereuta, O.M. et al. Metabolite signature in acute ischemic stroke thrombi: a systematic review. J Thromb Thrombolysis 56, 594–602 (2023). https://doi.org/10.1007/s11239-023-02869-9
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DOI: https://doi.org/10.1007/s11239-023-02869-9