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Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

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Abstract

The aim of the present study was to investigate the frequency and the possible association between thrombophilic mutations of factor V Leiden (FVL) and prothrombin G20210A with preeclampsia among Kurdish population of Western Iran. We studied 198 women with preeclampsia including 128 women with mild and 70 women with severe forms and 101 healthy pregnant women with uncomplicated pregnancy. Among cases there were 23 women with early onset preeclampsia and 175 cases with late-onset preeclampsia. The sample was genotyped by polymerase chain reaction-restriction fragment-length polymorphism using Mnl I and Hind III for FVL and prothrombin G20210A, respectively. The frequency of heterozygous FVL mutation was 7.6% among all preeclamptic women (8.6% in mild and 5.7% in severe preeclamptic women) and 7.9% in controls (P > 0.05). However, the prevalence of heterozygous FVL were 10.5 and 3.9% among severe preeclamptic women with early onset and late-onset preeclampsia, respectively (P > 0.05). The prevalence of prothrombin G20210A were 1.6, 2.9, and 3% among women with mild preeclamsia, severe preeclampsia and controls, respectively (P > 0.05). The level of serum triglycerides (TG) was significantly higher among women with preeclampsia compared to healthy pregnant women that was not associated with the two thrombophilic mutations. Our results indicate that neither FVL nor prothrombin G20210A could be a risk factor for preeclampsia in our population. However, high prevalence of FVL in preeclamptic women with early onset compared to those with late-onset preeclampsia may suggest a role for this mutation in predisposition to early onset preeclampsia that need to be confirmed with larger sample size.

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Acknowledgments

This work was performed in partial fulfillment of the requirements for MD of Dr. Faranak Jalilvand, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Shohreh Malek-Khosravi & Faranak Jalilvand

  2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Zohreh Rahimi & Ziba Rahimi

  3. Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Daneshgah Avenue, Kermanshah, P.O. Box 67148-69914, Iran

    Zohreh Rahimi

  4. Division of Neuroscience & Behavior, NIAAA, National Institutes of Health, Rockville, MD, USA

    Abbas Parsian

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  1. Shohreh Malek-Khosravi
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  2. Zohreh Rahimi
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  4. Faranak Jalilvand
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Correspondence to Zohreh Rahimi.

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Malek-Khosravi, S., Rahimi, Z., Rahimi, Z. et al. Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran. J Thromb Thrombolysis 33, 109–115 (2012). https://doi.org/10.1007/s11239-011-0653-y

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