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Thyroid-associated autoimmune coagulation disorders

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Abstract

Abnormalities of blood coagulation are not rarely observed in patients with thyroid dysfunctions and may range from subclinical laboratory abnormalities to clinically significant hemorrhagic or thrombotic complications. In this review, we summarize the current knowledge on thyroid-associated autoimmune coagulation disorders (i.e., autoimmune thrombocytopenic purpura, antiphospholipid syndrome, and autoantibodies against coagulation factor VIII) and discuss their laboratory characteristics, clinical impact, and recent progresses in the understanding of pathogenesis. Finally, we conclude that the prompt recognition of possible concomitant autoimmune coagulation disorders is important for the correct management of these patients.

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Authors and Affiliations

  1. Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

    Massimo Franchini

  2. Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona, Italy

    Giuseppe Lippi

  3. Laboratorio di Patologia Clinica, Ospedale “Carlo Poma”, Mantova, Italy

    Franco Manzato

  4. Dipartimento di Medicina, Struttura Complessa di Medicina Interna, Ospedale “Carlo Poma”, Mantova, Italy

    Pier Paolo Vescovi

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  1. Massimo Franchini
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  2. Giuseppe Lippi
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  3. Franco Manzato
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  4. Pier Paolo Vescovi
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Correspondence to Massimo Franchini.

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Franchini, M., Lippi, G., Manzato, F. et al. Thyroid-associated autoimmune coagulation disorders. J Thromb Thrombolysis 29, 87–91 (2010). https://doi.org/10.1007/s11239-009-0327-1

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