Abstract
Introduction
The aim was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler monitoring using a 2–4 MHz probe.
Materials and methods
About 10 healthy volunteers underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA), thrombotripsy of the radial artery and a standard 20-min neurosonologic examination (NSE) in 2-week intervals. Platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, α-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a) were examined before, at the end and 24 h after a thrombotripsy. All adverse events were monitored.
Results
After a thrombotripsy of the MCA, PAI-1 antigen, tPA antigen, fibrinogen and AP activity were significantly decreased by a mean of 32, 23, 7, and 4% respectively (P < 0.05 in all cases). After a thrombotripsy of the RA, there was a significant decrease in tPA antigen alone by an average of 14% (P < 0.05). Standard NSE did not affect any of the measured factors.
Conclusions
Thrombotripsy with 1-hour TCD monitoring using a 2–4 MHz diagnostic probe may affect the fibrinolytic system in humans.
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Acknowledgment
The study was supported by the grant of Internal Grant Agency, Ministry of Health, Czech Republic, number NR/9487-3/2007.
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Školoudík, D., Fadrná, T., Bar, M. et al. Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2–4 MHz transcranial probe. J Thromb Thrombolysis 26, 119–124 (2008). https://doi.org/10.1007/s11239-007-0079-8
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DOI: https://doi.org/10.1007/s11239-007-0079-8