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Synthesis, structure, and properties of 2-[(4,6-di-tert-butyl-2,3-dihydroxyphenyl)thio]acetic acid amides

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Russian Chemical Bulletin Aims and scope

Abstract

New potential biologically active derivatives, in which the sterically hindered pyrocatechol moiety is linked through a 2-thioacetyl covalent bridge to a number of secondary amines, pharmacophore γ-aminobutyric acid, and 2-amino-4-dimethylamino-1,3,5-triazine, were synthesized. The structures of most of the synthesized compounds were studied by X-ray diffraction.

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Author information

Authors and Affiliations

  1. Institute of Physical and Organic Chemistry, Southern Federal University, 194/2 prosp. Stachki, 344090, Rostov-on-Don, Russian Federation

    L. Yu. Ukhin, D. V. Alexeenko, L. V. Belousova, T. N. Gribanova, A. S. Morkovnik, G. S. Borodkin, O. I. Dmitrieva & V. A. Podshibyakin

  2. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    L. G. Kuz’mina

  3. Federal Research Centre “Southern Scientific Centre of the Russian Academy of Sciences”, 41 ul. Chekhova, 344006, Rostov-on-Don, Russian Federation

    E. N. Shepelenko

Authors
  1. L. Yu. Ukhin
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  2. L. G. Kuz’mina
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  3. D. V. Alexeenko
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  4. L. V. Belousova
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  8. G. S. Borodkin
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  9. O. I. Dmitrieva
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Corresponding authors

Correspondence to L. Yu. Ukhin, L. G. Kuz’mina or E. N. Shepelenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1368–1376, July, 2021.

The study was financially supported by the Ministry of Science and Higher Education of the Russian Federation (state assignment 0852-2020-0031 in the field of scientific research of the Southern Federal University, project No. FENW-2020-0031) using facilities of the Center of Collective Use of the Southern Federal University.

This paper does not contain descriptions of studies on animals or humans.

The authors declare no competing interests.

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Ukhin, L.Y., Kuz’mina, L.G., Alexeenko, D.V. et al. Synthesis, structure, and properties of 2-[(4,6-di-tert-butyl-2,3-dihydroxyphenyl)thio]acetic acid amides. Russ Chem Bull 70, 1368–1376 (2021). https://doi.org/10.1007/s11172-021-3225-0

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  • DOI: https://doi.org/10.1007/s11172-021-3225-0

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