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Antitumor effect of the conjugate of synthetic carbohydrate moiety of the tumor-associated ganglioside GM3 with hemocyanin in combination with the cytostatic cyclophosphamide

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Abstract

Based on the carbohydrate chains of tumor-associated ganglioside, polyvalent carbohydrate-protein conjugate 1 was synthesized suitable as a prototype of a cancer vaccine containing ∼400 residues of 3′-(N-acetyl-a-neuraminyl)lactose (3′-sialyllactose) per macromolecular complex of the hemocyanin protein of the Megathura crenulata keyhole limpet. The integrated antitumor effect of neoglycoconjugate 1 in combintion with the cytostatic cyclophosphamide was studied on the C57Bl/6 mice with transplanted melanoma B16/F0 cells.

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Authors and Affiliations

  1. National Research Center “Institute of Immunology”, Federal Medical-Biological Agency of Russia, 24/2, Kashirskoe sh., 115478, Moscow, Russian Federation

    O. V. Kozyreva, E. M. Novikova & R. N. Stepanenko

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninskii prosp., 119991, Moscow, Russian Federation

    E. A. Khatuntseva, Yu. E. Tsvetkov & N. E. Nifantiev

Authors
  1. O. V. Kozyreva
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  2. E. M. Novikova
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  3. E. A. Khatuntseva
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  4. Yu. E. Tsvetkov
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  5. N. E. Nifantiev
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  6. R. N. Stepanenko
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Corresponding author

Correspondence to R. N. Stepanenko.

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Dedicated to Academician of the Russian Academy of Sciences O. N. Chupakhin on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1431–1437, June, 2014.

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Kozyreva, O.V., Novikova, E.M., Khatuntseva, E.A. et al. Antitumor effect of the conjugate of synthetic carbohydrate moiety of the tumor-associated ganglioside GM3 with hemocyanin in combination with the cytostatic cyclophosphamide. Russ Chem Bull 63, 1431–1437 (2014). https://doi.org/10.1007/s11172-014-0614-7

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  • DOI: https://doi.org/10.1007/s11172-014-0614-7

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