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Reductive activation of arenecarbonitriles for the reactions with some carbon-centered electrophiles: the reaction mechanisms and synthetic applications

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Abstract

Synthetic and mechanistic aspects of the developed approach to the activation of aromatic nitriles are considered. The approach is based on the transformation of aromatic nitriles into stable anionic reduced forms. The latter, as shown for the reactions with alkyl halides and cyanoarenes, are promising reactants for the reactions with carbon-centered electrophiles.

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  1. N. N. Vorozhtsov Novosibirsk Iinstitute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent’eva, 630090, Novosibirsk, Russian Federation

    T. A. Vaganova, E. V. Panteleeva & V. D. Shteingarts

  2. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    E. V. Panteleeva & V. D. Shteingarts

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  1. T. A. Vaganova
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  2. E. V. Panteleeva
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 754–765, April, 2008.

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Vaganova, T.A., Panteleeva, E.V. & Shteingarts, V.D. Reductive activation of arenecarbonitriles for the reactions with some carbon-centered electrophiles: the reaction mechanisms and synthetic applications. Russ Chem Bull 57, 768–779 (2008). https://doi.org/10.1007/s11172-008-0116-6

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