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Flavonoid dihydromyricetin-mediated silver nanoparticles as potential nanomedicine for biomedical treatment of infections caused by opportunistic fungal pathogens

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Abstract

Dihydromyricetin-mediated silver nanoparticles (DMY-AgNPs) were synthesized and their efficacy against fungal pathogens tested in vitro. The shape of DMY-AgNPs appeared to be spherical with size of ~34 nm. Fourier-transform infrared (FT-IR) analysis indicated that –OH and C=O groups were involved in nanoparticle formation. The XRD pattern of DMY-AgNPs showed strong peaks at 38°, 44°, and 64°, corresponding to reflection from (111), (200), and (220) planes. Five opportunistic fungal pathogens, namely Aspergillus fumigatus, Aspergillus niger, Paecilomyces formosus, Candida albicans, and Candida parapsilosis, were isolated from patients suffering from respiratory tract infections. Growth of each fungal strain was inhibited by DMY-AgNPs. The zone of inhibition of DMY-AgNPs against A. fumigatus, A. niger, P. formosus, C. albicans, and C. parapsilosis was 17.6, 19.2, 22.2, 15.8, and 18.5 mm. The minimal inhibitory concentration was found to be 0.83, 0.73, 0.67, 0.95, and 0.89 µg mL−1, respectively. This is the first report on DMY-AgNPs as an effective antifungal agent. DMY-AgNPs are a potential alternative to commercially available antifungal fungicidals.

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Acknowledgements

The authors are very grateful to the Localization and Development Technology Platform for the Infectious Diseases Surveillance and the Detection Project at Kind Abdulaziz City for Science and Technology.

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Authors and Affiliations

  1. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Fuad Ameen

  2. National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh, 11442, Saudi Arabia

    Sami A. AlYahya, Muhammed A. Bakhrebah & Majed S. Nassar

  3. Biology Department, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

    Amal Aljuraifani

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  1. Fuad Ameen
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Correspondence to Fuad Ameen.

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Ameen, F., AlYahya, S.A., Bakhrebah, M.A. et al. Flavonoid dihydromyricetin-mediated silver nanoparticles as potential nanomedicine for biomedical treatment of infections caused by opportunistic fungal pathogens. Res Chem Intermed 44, 5063–5073 (2018). https://doi.org/10.1007/s11164-018-3409-x

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