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5-Chloropyrazole-4-carboxaldehydes as synthon in heterocyclic synthesis

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Abstract

This review presents a systematic and comprehensive survey of the method of preparation and the chemical reactivity of 5-chloropyrazole-4-carbaldehyde. These compounds are important intermediates for the synthesis of a variety of otherwise difficult to obtain, synthetically useful, and novel heterocyclic systems.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science and Arts, Ulla, Taibah University, Madina, Saudi Arabia

    Moustafa A. Gouda

  2. Chemistry Department, Faculty of Science, Mansoura University, 35516, Mansoura, Egypt

    Moustafa A. Gouda & Khaled M. Elattar

  3. Photochemistry Department (Heterocyclic Unit), National Research Center, 12622, Dokki, Giza, Egypt

    Ameen A. Abu-Hashem

  4. Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Saudi Arabia

    Ameen A. Abu-Hashem

  5. Phytochemistry & Plant Systematic Department Pharmaceutical Industries Research Division, National Research Centre, 12622, Dokki, Giza, Egypt

    Hamada H. Saad

  6. Chemistry Department, Faculty of Education, Sert University, Sert, Libya

    Khaled M. Elattar

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  1. Moustafa A. Gouda
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Gouda, M.A., Abu-Hashem, A.A., Saad, H.H. et al. 5-Chloropyrazole-4-carboxaldehydes as synthon in heterocyclic synthesis. Res Chem Intermed 42, 2119–2162 (2016). https://doi.org/10.1007/s11164-015-2139-6

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