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ZrCl4 as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions

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Abstract

A highly atom-economic, one-pot synthesis of functionalized piperidines is reported by a multi-component condensation reaction between β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of ZrCl4. The advantages of this protocol are good yields, short reaction time, mild reaction conditions, no need for column chromatography, more readily available, inexpensive catalyst, and simple work-up procedure.

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Acknowledgment

We gratefully acknowledge the funding support received for this project from the Research Council of the University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

    Jasem Aboonajmi, Mir Rasul Mousavi, Malek Taher Maghsoodlou, Nourallah Hazeri & Amin Masoumnia

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  1. Jasem Aboonajmi
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  2. Mir Rasul Mousavi
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  3. Malek Taher Maghsoodlou
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  4. Nourallah Hazeri
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  5. Amin Masoumnia
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Correspondence to Malek Taher Maghsoodlou.

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Aboonajmi, J., Mousavi, M.R., Maghsoodlou, M.T. et al. ZrCl4 as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions. Res Chem Intermed 41, 1925–1934 (2015). https://doi.org/10.1007/s11164-013-1320-z

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  • DOI: https://doi.org/10.1007/s11164-013-1320-z

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