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Synthesis and antimicrobial evaluation of ferulic acid derivatives

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Abstract

A series of ferulic acid derivatives (1–38) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity against different Gram-positive and Gram-negative bacterial and fungal strains by the tube dilution method. Results of antimicrobial screening indicated that compound 1 was the most active antimicrobial agent (pMICam = 1.83 μM/ml).

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Anurag Khatkar, Arun Nanda, Pradeep Kumar & Balasubramanian Narasimhan

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  1. Anurag Khatkar
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  2. Arun Nanda
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  3. Pradeep Kumar
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  4. Balasubramanian Narasimhan
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Correspondence to Balasubramanian Narasimhan.

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Khatkar, A., Nanda, A., Kumar, P. et al. Synthesis and antimicrobial evaluation of ferulic acid derivatives. Res Chem Intermed 41, 299–309 (2015). https://doi.org/10.1007/s11164-013-1192-2

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