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Performance of the EORTC questionnaire for the assessment of quality of life in head and neck cancer patients EORTC QLQ-H&N35: a methodological review

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Abstract

Purpose

The EORTC QLQ-H&N35 (H&N35) is widely used to measure quality of life in head and neck cancer patients. The aims of this study were to obtain insight into a) the languages in which the H&N35 has been used and the psychometric properties in those languages, b) the study designs, and c) its acceptance by patients and investigators.

Methods

A systematic literature review was performed searching for all original papers that had used at least one item of the H&N35. Identified papers were read and the information about methodological issues abstracted statistically analysed.

Results

A total of 136 papers were identified. The H&N35 was administered in 19 different languages in 27 countries. The study design was cross-sectional in the majority of studies (53 %), prospective cohort studies (31 %), phase-II-trials (7 %), phase-III-trials (6 %) and case–control studies (1 %). The scales with the highest percentages of missing values were Sexuality (11.5 %) and Speech (7 %). The median Cronbach’s alpha of the multi-item scales ranged from 0.61 (Senses) to 0.93 (Sexuality). Construct validity was rarely investigated. On average, 12 scales (range 0-18) of the instrument were used by the investigators. The scale most often used was swallowing (in 85 % of studies) and least often used was Weight Gain (39 %).

Conclusion

The H&N35 is widely used throughout the world, mainly in observational studies, and has demonstrated robust psychometric features in different languages. However, some methodological problems reported imply that the instrument can be improved in some areas.

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Authors and Affiliations

  1. Institute of Medical Biostatistics, Epidemiology, and Informatics, University of Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany

    Susanne Singer

  2. Department of Oncology, Hospital de Navarra, Pamplona, Spain

    Juan Ignacio Arraras

  3. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan

    Wei-Chu Chie

  4. Psychosocial Oncology and Clinical Practice Research Group, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK

    Sheila E. Fisher

  5. Department of Radiation Therapy, University Hospital Schleswig–Holstein, Campus Kiel, Germany

    Razvan Galalae & Claudia Schmalz

  6. Department of Otolaryngology and Head and Neck Surgery, Sahlgrenska University Hospital, Gøteborg University, Gøteborg, Sweden

    Eva Hammerlid

  7. Clinic of Hospital Dentistry, School of Dentistry, University of Athens, Athens, Greece

    Ourania Nicolatou-Galitis

  8. Otolaryngology/Head & Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands

    Irma Verdonck-de Leeuw

  9. Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria

    Eva Gamper

  10. Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany

    Susanne Singer, Judith Keszte & Dirk Hofmeister

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  1. Susanne Singer
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Singer, S., Arraras, J.I., Chie, WC. et al. Performance of the EORTC questionnaire for the assessment of quality of life in head and neck cancer patients EORTC QLQ-H&N35: a methodological review. Qual Life Res 22, 1927–1941 (2013). https://doi.org/10.1007/s11136-012-0325-1

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