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Aquaporins as targets of pharmacological plant-derived compounds

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Abstract

Aquaporins (AQPs) are integral membrane proteins that serve as selective pores through which water and small solutes cross the plasma membranes of many human tissue and cell types. They have been identified in epithelia and endothelia involved in fluid transport, such as kidney tubules and glandular epithelia, glial cells, epidermis, and adipocytes. The pathophysiological roles of these proteins and the primary and secondary involvement of AQPs are becoming apparent in diverse clinical disorders, from diabetes insipidus to various forms of edema. The advanced understanding of aquaporin biology, from the structural determinants of channel permeability to the assignment of their physiological function in different organs, will allow the use of AQPs as targets for the therapy of a wide array of diseases. In this review, the mode of action of clinically-effective plant formulae on human AQPs-related diseases at the molecular, cellular, and organism levels is explored. The use of pharmacological plant-derived compounds as a possible strategy in the therapy of diseases related to altered water homeostasis should stimulate debate and further research objectives.

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References

  • Aburada T, Ikarashi N, Kagami M, Ichikawa Y, Sugitani M et al (2011) Yakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice. Phytother Res 25:897–903

    PubMed  Google Scholar 

  • Beitz E (2007) Jammed traffic impedes parasite growth. Proc Natl Acad Sci USA 104:13855–13856

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bellemère G, Von Stetten O, Oddos T (2008) Retinoic acid increases aquaporin 3 expression in normal human skin. J Invest Dermatol 128:542–548

    PubMed  Google Scholar 

  • Blocher J, Eckert I, Elster J, Wiefek J, Eiffert H, Schmidt H (2011) Aquaporins AQP1 and AQP4 in the cerebrospinal fluid of bacterial meningitis patients. Neurosci Lett 504:23–27

    CAS  PubMed  Google Scholar 

  • Bossini N, Savoldi S, Franceschini F, Mombelloni S, Baronio M et al (2001) Clinical and morphological features of kidney involvement in primary Sjogren’s syndrome. Nephrol Dial Transplant 16:2328–2336

    CAS  PubMed  Google Scholar 

  • Boury-Jamot M, Sougrat R, Tailhardat M, Le Varlet B, Bonté F et al (2006) Expression and function of aquaporins in human skin: is aquaporin-3 just a glycerol transporter? Biochim Biophys Acta Biomembr 1758:1034–1042

    CAS  Google Scholar 

  • Brooks HL, Regan JW, Yool AJ (2000) Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore region. Mol Pharmacol 57:1021–1026

    CAS  PubMed  Google Scholar 

  • Cai B, Jiang T (1994) Study on preventive and curative effects of liu wei di huang tang on tumors. J Tradit Chin Med 14:207–211

    CAS  PubMed  Google Scholar 

  • Cals-Grierson MM (2007) Modulation of activity of the adipocyte aquaglyceroporin channel by plant extracts. Int J Cosmet Sci 29:7–14

    PubMed  Google Scholar 

  • Cao C, Wan S, Jiang Q, Amaral A, Lu S et al (2007) All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J Cell Physiol 215:506–516

    Google Scholar 

  • Cao HY, Wu QH, Huang P, He JY (2009) Impacts of the formula of Suoquanwan (SQW) on expression of AQP-2 mRNA and AVPR-V2 mRNA in the kidney of rat polyuria model of Yang-deficiency. Zhongyaocai 32:926–928

    PubMed  Google Scholar 

  • Chen GX, Lao SX, Huang ZX (2005) Effect of Chinese herbs on expression of aquaporin 3, 4 gene in gastric mucosa of patients with Pi-Wei Damp-Heat syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 25:199–202

    PubMed  Google Scholar 

  • Danno K, Horio T, Takigawa M, Imamura S (1984) Role of oxygen intermediates in UV-induced epidermal cell injury. J Invest Dermatol 83:166–168

    CAS  PubMed  Google Scholar 

  • Detmers FJ, de Groot BL, Muller EM, Hinton A, Konings IB et al (2006) Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action. J Biol Chem 281:14207–14214

    CAS  PubMed  Google Scholar 

  • Devuyst O, Yool AJ (2010) Aquaporin-1: new developments and perspectives for peritoneal dialysis. Perit Dial Int 30:135–141

    CAS  PubMed  Google Scholar 

  • Faghiri Z, Skelly PJ (2009) The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake. FASEB J 23:2780–2789

    CAS  PubMed Central  PubMed  Google Scholar 

  • Fernandez-Llama P, Andrews P, Turner R, Saggi S, Dimari J et al (1999) Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats. J Am Soc Nephrol 10:1658–1668

    CAS  PubMed  Google Scholar 

  • Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T et al (2006) Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice. Proc Natl Acad Sci USA 103:13532–13536

    CAS  PubMed Central  PubMed  Google Scholar 

  • Fujiyoshi Y, Mitsuoka K, de Groot BL, Philippsen A, Grubmüller H et al (2002) Structure and function of water channels. Curr Opin Struct Biol 12:509–515

    CAS  PubMed  Google Scholar 

  • Gao J, Wang X, Chang Y, Zhang J, Song Q et al (2006) Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1. Anal Biochem 350:165–170

    CAS  PubMed  Google Scholar 

  • Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S et al (2004) Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem 279:31010–31017

    CAS  PubMed  Google Scholar 

  • Gruber JV, Holtz R (2010) Examining the genomic influence of skin antioxidants. In Vitro Mediat Inflamm 2010:1–10

    Google Scholar 

  • Hansen M, Kun JF, Schultz JE, Beitz E (2002) A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem 277:4874–4882

    CAS  PubMed  Google Scholar 

  • Hara M, Verkman AS (2003) Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. Proc Natl Acad Sci USA 100:7360–7365

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hara-Chikuma M, Verkman AS (2005) Aquaporin-3 functions as a glycerol transporter in mammalian skin. Biol Cell 97:479–486

    Google Scholar 

  • Huber VJ, Tsujita M, Yamazaki M, Sakimura K, Nakada T (2007) Identification of arylsulfonamides as aquaporin 4 inhibitors. Bioorg Med Chem Lett 17:1270–1273

    CAS  PubMed  Google Scholar 

  • Huber VJ, Tsujita M, Kwee IL, Nakada T (2009) Inhibition of aquaporin 4 by antiepileptic drugs. Bioorg Med Chem 17:418–424

    CAS  PubMed  Google Scholar 

  • Igarashi H, Huber VJ, Tsujita M, Nakada T (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol Sci 32:113–116

    PubMed Central  PubMed  Google Scholar 

  • Ishida H, Inaoka Y, Shibatani J, Fukushima M, Tsuji K (1999) Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries. Biol Pharm Bull 22:1189–1192

    CAS  PubMed  Google Scholar 

  • Isohama Y (2006) Aquaporin modification: a new molecular mechanism to concern. J Pharm Soc Jpn 126:70–73

    Google Scholar 

  • Jeong NY, Yoon YG, Rho JH, Lee JS, Lee SY et al (2011) The novel resveratrol analog HS-1793-induced polyploid LNCaP prostate cancer cells are vulnerable to downregulation of Bcl-xL. Int J Oncol 38:1597–1604

    CAS  PubMed  Google Scholar 

  • Kang DG, Sohn EJ, Lee HS (2003) Effects of glycyrrhizin on renal functions in association with the regulation of water channels. Am J Chin Med 31:403–413

    CAS  PubMed  Google Scholar 

  • Kang DG, Sohn EJ, Moon MK, Mun YJ, Woo WH et al (2006) Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats. J Ethnopharmacol 104:47–53

    PubMed  Google Scholar 

  • Kataya HA, Hamza AA (2008) Red cabbage (Brassica oleracea) ameliorates diabetic nephropathy in rats. Evid Based Complement Altern Med 5:281–287

    Google Scholar 

  • Khatun S, Cakilcio U, Chatterjee NC (2011) Phytochemical constituents vis-a-vis histochemical localization of forskolin in a medicinal plant Coleus forskohlii Briq. J Med Plant Res 5:711–718

    Google Scholar 

  • Kim JS, Na CS, Pak SC, Kim YG (2000a) Effects of yukmi, an herbal formula, on the liver of senescence accelerated mice (SAM) exposed to oxidative stress. Am J Chin Med 28:343–350

    CAS  PubMed  Google Scholar 

  • Kim SW, Jeon YS, Lee JU, Kang DG, Kook H et al (2000b) Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats. Kidney Int 57:1643–1650

    CAS  PubMed  Google Scholar 

  • Kim SW, Lee J, Nah MY, Kang DG, Ahn KY et al (2001) Cisplatin decreases the abundance of aquaporin water channels in rat kidney. J Am Soc Nephrol 12:875–882

    CAS  PubMed  Google Scholar 

  • King LS, Kozono D, Agre P (2004) From structure to disease: the evolving tale of aquaporin biology. Nat Rev Mol Cell Biol 5:687–698

    CAS  PubMed  Google Scholar 

  • Kondo H, Shimomura I, Kishida K, Kuriyama H, Makino Y et al (2002) Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem 269:1814–1826

    CAS  PubMed  Google Scholar 

  • Kramer W, Thormann J, Kindler M, Schlepper M (1987) Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittel Forsch 37:364–367

    CAS  Google Scholar 

  • Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252–4263

    CAS  PubMed  Google Scholar 

  • Kurita T, Nakamura K, Tabuchi M, Orita M, Ooshima K et al (2011) Effects of Gorei-san: a traditional japanese kampo medicine, on aquaporin 1,2,3,4 and V2R mRNA expression in rat kidney and forebrain. J Med Sci 11:30–38

    Google Scholar 

  • Kuwahara M, Fushimi K, Terada Y, Bai L, Marumo F et al (1995) cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem 270:10384–10387

    CAS  PubMed  Google Scholar 

  • Laird MD, Sangeetha SR, Swift AEB, Meiler SE, Vender JR et al (2010) Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4. J Neurochem 113:637–648

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lee JM, Johnson JA (2004) An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 37:139–143

    CAS  PubMed  Google Scholar 

  • Lee J, Yoo KS, Kang DG, Kim SW, Choi KC (2001) Gentamicin decreases the abundance of aquaporin water channels in rat kidney. Jap J Pharmacol 85:391–398

    PubMed  Google Scholar 

  • Li F, Wang SC, Ren QY, Wang W, Shang GW et al (2008) Novel exploration of cathartic pharmacology induced by rhubarb. Zhongguo Zhong Yao Za Zhi 33:481–484

    PubMed  Google Scholar 

  • Lin X, Sze SCW, Tong Y, Zhang Z, Feng Y et al (2010) Protective effect of Dendrobium officinale polysaccharides on experimental Sjogren’s syndrome. J Complement Integr Med 7:14

    Google Scholar 

  • Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P et al (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci USA 99:6053–6058

    CAS  PubMed Central  PubMed  Google Scholar 

  • Maeda N, Funahashi T, Hibuse T, Nagasawa A, Kishida K et al (2004) Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci USA 101:7801–17806

    Google Scholar 

  • Manley GT, Binder DK, Papadopoulos MC, Verkman AS (2004) New insights into water transport and edema in the central nervous system form phenotype analysis of aquaporin-4 null mice. Neuroscience 129:983–991

    CAS  PubMed  Google Scholar 

  • Marr N, Bichet DG, Hofes S, Savelkoul PJM, Konings IBM et al (2002) Cell-biologic and functional analyses of five new aquaporin 2 missense mutations that cause recessive nephrogenic diabetes insipidus. J Am Soc Nephrol 13:2267–2277

    CAS  PubMed  Google Scholar 

  • Migliati E, Meurice N, DuBois P, Fang JS, Somasekharan S et al (2009) Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Mol Pharmacol 76:105–112

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mishra BB, Tiwari VK (2011) Natural products: an evolving role in future drug discovery. Eur J Med Chem 46:4769–4807

    CAS  PubMed  Google Scholar 

  • Mola MG, Nicchia GP, Svelto M, Spray DC, Frigeri A (2009) Automated cell-based assay for screening of aquaporin inhibitors. Anal Chem 81:8219–8229

    CAS  PubMed Central  PubMed  Google Scholar 

  • Monzani E, Shtil AA, La Porta Caterina AM (2007) The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis. Curr Drug Targets 8:1132–1137

    CAS  PubMed  Google Scholar 

  • Nakamura Y, Suzuki Y, Tsujita M, Huber VJ, Yamada K et al (2011) Development of a novel ligand, [11C]TGN-020, for aquaporin 4 positron emission tomography imagine. ACS Chem Neurosci 2:568–571

    CAS  PubMed Central  PubMed  Google Scholar 

  • Newby ZER, O’Connell J, Robles-Colmenares Y, Khademi S, Miercke LJ et al (2008) Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Nat Struct Mol Biol 15:619–625

    CAS  PubMed Central  PubMed  Google Scholar 

  • Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75:311–335

    CAS  PubMed Central  PubMed  Google Scholar 

  • Nicchia GP, Frigeri A, Liuzzi GM, Svelto M (2003) Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes. FASEB J 17:508–1510

    Google Scholar 

  • Nicchia GP, Srinivas M, Li W, Brosnan CF, Frigeri A et al (2005) New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J 19:1674–1676

    CAS  PubMed  Google Scholar 

  • Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P et al (2002) Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82:205–244

    CAS  PubMed  Google Scholar 

  • Niemietz CM, Tyerman SD (2002) New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin. FEBS Lett 531:443–447

    CAS  PubMed  Google Scholar 

  • Noda Y, Sasaki S (2004) Molecular mechanisms and drug development in aquaporin water channel diseases: molecular mechanism of water channel aquaporin-2 trafficking. J Pharmacol Sci 96:249–254

    CAS  PubMed  Google Scholar 

  • Ohsawa T, Yukawa M, Takao C, Murayama M, Bando H (1992) Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity. Chem Pharm Bull 40:143–147

    CAS  PubMed  Google Scholar 

  • Pei J, Yool AJ (2010) Inhibitory activity of plant extracts on Plasmodium falciparum aquaporin. Proc Aust Physiol Pharmacol Soc 41:65

  • Petit K, Biard JF (2013) Marine natural products and related compounds as anticancer agents: an overview of their clinical status. Anticancer Agents Med Chem 13:603–631

    CAS  PubMed  Google Scholar 

  • Preston GM, Jung JS, Guggino WB, Agre P (1993) The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J Biol Chem 268:17–20

    CAS  PubMed  Google Scholar 

  • Promeneur D, Lunde LK, Amiry-Moghaddam M, Agre P (2013) Protective role of brain water channel AQP4 in murine cerebral malaria. Proc Natl Acad Sci USA 110:1035–1040

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rabb H, Chamoun F, Hotchkiss J (2001) Molecular mechanisms underlying combined kidney-lung dysfunction during acute renal failure. Contrib Nephrol 132:41–52

    CAS  PubMed  Google Scholar 

  • Ren Z, Wang Y, Duan T, Patel J, Liggett T et al (2012) Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica. J Immunol 189:4602–4611

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ribeiro MC, Hirt L, Bogousslavsky J, Regli L, Badaut J (2006) Time course of aquaporin expression after transient focal cerebral ischemia in mice. J Neurosci Res 83:1231–1240

    Google Scholar 

  • Sanders OI, Rensing C, Kuroda M, Mitra B, Rosen BP (1997) Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli. J Bacteriol 179:3365–3367

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sato Y, Hanawa T, Arai M, Cyong J, Fukuzawa M et al (2005) Introduction to KAMPO—Japanese Medicine. Elsevier Japan KK, Tokyo, p 134

    Google Scholar 

  • Seeliger D, Zapater C, Krenc D, Haddoub R, Flitsch S et al (2013) Discovery of novel human aquaporin-1 blockers. ACS Chem Biol 8:249–256

    CAS  PubMed  Google Scholar 

  • Shan SJ, Xiao T, Chen J, Geng SL, Li CPETAL (2012) Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. Int J Mol Med 29:625–629

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shen JJ, Lin CJ, Hiang JL, Hsieh KH, Kuo ML (2003) The effect of liu-wei-di-huang wan on cytokine gene expression from human peripheral blood lymphocytes. Am J Chin Med 31:247–257

    PubMed  Google Scholar 

  • Søgaard R, Zeuthen T (2008) Test of blockers of AQP1 water permeability by a high-resolution method: no effects of tetraethylammonium ions or acetazolamide. Pflugers Arch 456:285–292

    PubMed  Google Scholar 

  • Sohn EJ, Kang DG, Lee HS (2003) Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats. Pharmacol Toxicol 93:116–122

    CAS  PubMed  Google Scholar 

  • Song X, Xu A, Pan W, Wallin B, Kivlin R et al (2008) Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. Int J Mol Med 22:229–236

    CAS  PubMed  Google Scholar 

  • Suksamrarn A, Ponglikitmongkol M, Wongkrajang K, Chindaduan A, Kittidanairak S et al (2008) Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: isolation, chemical modification and estrogenic activity evaluation. Bioorg Med Chem 16:6891–6902

    CAS  PubMed  Google Scholar 

  • Sukul NC, De A, Sinhababu SP, Sukul A (2003) Potentized mercuric chloride and Nux vomica facilitate water permeability in erythrocytes of a fresh-water catfish Clarius batrachus under acute ethanol intoxication. J Altern Complement Med 9:719–725

    CAS  PubMed  Google Scholar 

  • Suzuki Y, Nakamura Y, Yamada K, Huber VJ, Tsujita M et al (2013) Aquaporin-4 positron emission tomography imaging of the human brain: first report. J Neuroimaging 23:219–223

    PubMed  Google Scholar 

  • Tamarappo BK, Verkman AS (1998) Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Invest 101:2257–2267

    Google Scholar 

  • Tang YP, Cai DF, Liu J (2006) Research on acting mechanism of rhubarb on aquaporin-4 in rats with blood-brain barrier injury after acute cerebral hemorrhage. Chinese Zhongguo Zhong Xi Yi Jie He Za Zhi 26:152–156

    Google Scholar 

  • Tanimura Y, Hiroaki Y, Fujiyoshi Y (2009) Acetazolamide reversibly inhibits water conduction by aquaporin-4. J Struct Biol 166:16–21

    CAS  PubMed  Google Scholar 

  • Tong YC, Hung YC, Lin SN, Cheng JT (1996) Treatment effect of “ryu-wei-ti-huang-wan” (a Chinese herbal prescription) on the sexual performance of male rats with streptozotocin-induced diabetes. Int J Urol 57:230–234

    CAS  Google Scholar 

  • Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M et al (2006) Structural mechanism of plant aquaporin gating. Nature 439:688–694

    PubMed  Google Scholar 

  • Tradtrantip L, Zhang H, Anderson MO, Saadoun S, Phuan PW et al (2012) Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB J 26:1–12

    Google Scholar 

  • Wacker SJ, Aponte-Santamaría C, Kjellbom P, Nielsen S, de Groot B et al (2013) The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site. Mol Membr Biol 30:246–260

    CAS  PubMed  Google Scholar 

  • Wang F, Feng XC, Li YM, Yang H, Ma TH (2006) Aquaporins as potential drug targets. Acta Pharm Sin 27:395–401

    CAS  Google Scholar 

  • Wang L, Zhou GB, Liu P, Song JH, Liang Y et al (2008) Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA 25:4826–4831

    Google Scholar 

  • Wang H, Jin R, Tian P, Zhuo Z (2009) Enhanced expression of aquaporin-9 in rat brain edema induced by bacterial lipopolysaccharides. J Huazhong Univ Sci Technolog Med Sci 29:150–155

    CAS  PubMed  Google Scholar 

  • Wang G, Gao F, Zhang W, Chen J, Wang T, Zhang G, Shen L (2012) Involvement of Aquaporin 3 in Helicobacter pylori-related gastric diseases. PLoS ONE 7:e49104

    CAS  PubMed Central  PubMed  Google Scholar 

  • Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongko M, Arao Y et al (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in Vitro and in Vivo indicate estrogen receptor–dependent mechanisms. Environ Health Perspect 117:1155–1161

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wu NL, Fang JY, Chen M, Wu CJ, Huang CC et al (2011) Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage. J Agric Food Chem 59:8391–8400

    CAS  PubMed  Google Scholar 

  • Xiao L, Ng TB, Feng YB, Yao T, Wong JH et al (2011) Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren’s syndrome. Phytomed Int J Phytother Phytopharmacol 18:194–198

    CAS  Google Scholar 

  • Yan SC (1988) Clinical and experimental research on Polyporus umbellatus polysaccharide in the treatment of chronic viral hepatitis. Zhongguo Zhong Xi Yi Jie He Za Zhi 131:41–43

    Google Scholar 

  • Yang B, Kim JK, Verkman AS (2006) Comparative efficacy of HgCl2 with candidate aquaporin-1 inhibitors DMSO, gold, TEA+ and acetazolamide. FEBS Lett 580:6679–6684

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yang B, Zhang H, Verkman AS (2008) Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg Med Chem 16:7489–7493

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yazawa Y, Yokota M, Sugiyama K (2000) Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A. Biol Pharm Bull 23:1298–1302

    CAS  PubMed  Google Scholar 

  • Yi NY, Chu W, Koang NK (1965) Pharmacologic studies on liu wei di huang t’ang (decoction of Rehmannia with 6 components): its action on kidney function and blood pressure of rats with renal hypertension. Chin Med J Peking 84:433–436

    CAS  Google Scholar 

  • Yool AJ (2007) Functional domains of aquaporin-1: keys to physiology, and targets for drug discovery. Curr Pharm Des 13:3212–3221

    CAS  PubMed  Google Scholar 

  • Yool AJ, Stamer WD, Regan JW (1996) Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. Science 273:1216–1218

    CAS  PubMed  Google Scholar 

  • Yool A, Brokl O, Pannabecker T, Dantzler W, Stamer W (2002) Tetraethylammonium block of water flux in aquaporin-1 channels expressed in kidney thinlimbs of Henle’s loop and a kidney-derived cell line. BMC Physiol 2:4

    PubMed Central  PubMed  Google Scholar 

  • Yu J, Yool AJ, Schulten K, Tajkhorshid E (2006) Mechanism of gating and ion conductivity of a possible tetrameric pore in aquaporin-1. Structure 14:1411–1423

    CAS  PubMed  Google Scholar 

  • Yuan D, Mori J, Komastu KI, Makino T, Kano T et al (2004) An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium. Biol Pharm Bull 27:867–870

    CAS  PubMed  Google Scholar 

  • Zador Z, Bloch O, Yao X, Manley GT (2007) Aquaporins: role in cerebral edema and brain water balance. Prog Brain Res 161:185–194

    CAS  PubMed  Google Scholar 

  • Zelenina M, Zelenin S, Bondar AA, Brismar H, Aperia A (2002) Water permeability of aquaporin-4 is decreased by protein kinase C and dopamine. Am J Physiol Renal Physiol 283:309–318

    Google Scholar 

  • Zhang W, Zitron E, Homme M, Kihm L, Morath C et al (2007) Aquaporin-1 channel function is positively regulated by protein kinase C. J Biol Chem 282:20933–20940

    CAS  PubMed  Google Scholar 

  • Zhang WS, Li F, Bao JQ (2008) Regulatory effect of anthraquinone derivatives from rhubarb on aquaporin 4 expression in colon of rats and in LoVo cell line. Zhongguo Zhong Xi Yi Jie He Za Zhi 28:818–823

    CAS  PubMed  Google Scholar 

  • Zhang G, Zeng X, Han L, Wei JA, Huang H (2010) Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus Fries in normal rats. J Ethnopharmacol 128:433–437

    CAS  PubMed  Google Scholar 

  • Zhang ZQ, Song YL, Chen ZH, Shen Y, Bai CX (2011) Deletion of aquaporin 5 aggravates acute lung injury induced by Pseudomonas aeruginosa. J Trauma 71:1305–1311

    CAS  PubMed  Google Scholar 

  • Zhao J, Moore AN, Clifton GL, Dash PK (2005) Sulphoraphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. J Neurosci Res 82:499–506

    CAS  PubMed  Google Scholar 

  • Zheng Y (2005) Shihu in China pharmacopoeia. Chemical Technology Press, Beijing, pp 61–63

    Google Scholar 

  • Zhu N, Feng X, He C, Gao H, Yang L et al (2011) Defective macrophage function in aquaporin-3 deficiency. FASEB J 25:4233–4239

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was funded by projects of the CICYT (AGL2012-40175-C02-01). M.C. Martínez-Ballesta thanks the Spanish Ministerio de Ciencia e Innovación for funding through the “Ramón y Cajal” programme [Ref RYC-2009-04574]. The authors thank Dr. D. Walker for correction of the written English in the manuscript.

Conflict of interests

The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. Department of Plant Nutrition, Centro de Edafología y Biología Aplicada del Segura—CSIC, Apdo. Correos 164, Espinardo, 30100, Murcia, Spain

    María del Carmen Martínez-Ballesta & Micaela Carvajal

  2. Servicio de Microbiología, Complejo Hospitalario Universitario La Coruña, 15006, La Coruña, Spain

    Germán Bou

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  1. María del Carmen Martínez-Ballesta
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  2. Germán Bou
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  3. Micaela Carvajal
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Correspondence to María del Carmen Martínez-Ballesta.

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del Carmen Martínez-Ballesta, M., Bou, G. & Carvajal, M. Aquaporins as targets of pharmacological plant-derived compounds. Phytochem Rev 13, 573–586 (2014). https://doi.org/10.1007/s11101-013-9314-4

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  • DOI: https://doi.org/10.1007/s11101-013-9314-4

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