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Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism

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International Journal of Clinical Pharmacy Aims and scope Submit manuscript

Abstract

Background Testosterone administration was found to have a protective effect on thyroid autoimmunity in men with autoimmune (Hashimoto’s) thyroiditis. Objective The present study was aimed at assessing whether oral dehydroepiandrosterone affects thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with subclinical hypothyroidism induced by Hashimoto’s thyroiditis. Setting The study was conducted at Medical University of Silesia, Katowice, Poland. Method The study enrolled 32 elderly men with autoimmune hypothyroidism and low dehydroepiandrosterone-sulfate levels. Based on patient preference, the participants either received oral dehydroepiandrosterone (50 mg daily; n = 16) or remained untreated (n = 16). Apart from measuring antibody titers and hormone levels, we calculated baseline and post-treatment values of three structure parameters of thyroid homeostasis. Main outcome measure Serum titers of thyroid peroxidase and thyroglobulin antibodies. Results At baseline, there were no significant differences in the investigated parameters between both groups of men. All participants completed the study. Oral dehydroepiandrosterone increased dehydroepiandrosterone-sulfate and testosterone levels, as well as had a neutral effect on estradiol levels. The increase in dehydroepiandrosterone-sulfate correlated with treatment-induced changes in serum testosterone. Moreover, dehydroepiandrosterone reduced titers of thyroid peroxidase and thyroglobulin antibodies, decreased serum thyrotropin levels, reduced Jostel’s thyrotropin index as well as increased thyroid’s secretory capacity. Treatment-induced changes in thyroid antibody titers, thyrotropin levels, Jostel’s thyrotropin index and thyroid’s secretory capacity correlated with the increase in dehydroepiandrosterone-sulfate and testosterone levels. Conclusion The obtained results show that exogenous dehydroepiandrosterone may exert a beneficial effect on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in men with autoimmune thyroiditis and subclinical hypothyroidism.

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Notes

  1. Risky drinking was defined as alcohol consumption exceeding 14 standard drinks per week or 4 standard drinks per day; binge drinking was defined as five or more standard drinks on a single occasion; while a standard drink was defined as one 12-oz bottle of beer, one 5-oz glass of wine, or 1.5 oz of distilled spirits.

  2. Aminoglutethimide, amiodarone, anabolic steroids, antithyroid agents, bexarotene, cholecalciferol and its analogs, cholestyramine, colestipol, dopamine, estrogens, fluorouracil, furosemide, glucocorticoids, interferon-α, interleukin-2, iodides, lithium, methadone, mitotane, myo-inositol, nonsteroidal anti-inflammatory drugs, octreotide, perchlorates, salicylates, selenium, slow-release nicotinic acid or tamoxifen.

Abbreviations

CI:

Confidence interval

DHEA:

Dehydroepiandrosterone

DHEA-S:

Dehydroepiandrosterone-sulfate

IU:

International unit

SD:

Standard deviation

SPINA:

Structure parameter inference approach

TgAb:

Thyroglobulin antibodies

TPOAb:

Thyroid peroxidase antibodies

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Acknowledgements

The authors would like to thank Ewa Zmuda, a professional translator, for English language editing.

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This work was not supported by any external source of funding.

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Authors and Affiliations

  1. Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752, Katowice, Poland

    Robert Krysiak, Witold Szkróbka & Bogusław Okopień

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  1. Robert Krysiak
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  2. Witold Szkróbka
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  3. Bogusław Okopień
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Correspondence to Robert Krysiak.

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Krysiak, R., Szkróbka, W. & Okopień, B. Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism. Int J Clin Pharm 43, 998–1005 (2021). https://doi.org/10.1007/s11096-020-01207-w

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  • DOI: https://doi.org/10.1007/s11096-020-01207-w

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