Abstract
Background Data is lacking on types and severities of drug-related problems (DRPs) in hospitalized surgical patients in China. Objective To identify and categorize types and causes of DRPs, and to assess severities of these DRPs. Setting An academic teaching hospital in Chongqing, China. Method We retrospectively reviewed all medication orders for patients in six surgical departments during a six-month period. DRPs were classified using the Pharmaceutical Care Network Europe (PCNE) classification, and the severity ratings of these DRPs were based on the National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP) classification. Main outcome measure The number, types, causes and severities of the DRPs. Results A total of 291,944 medication orders in 10,643 patients were reviewed, and 3548 DRPs were identified. The average DRP number per patient was 0.3. The most common problem was treatment effectiveness (39.9%) and the major cause of the problems was dose selection (47.0%). Total 80.1% of the DRPs were rated at severity categories B to D (causing no or potential harm), whereas 19.9% were rated as categories E to H (causing actual harm). Conclusion DRPs are common in surgical patients, and prospective pharmacist medication order review services are needed to improve patients’ pharmaceutical care.
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References
Pharmaceutical Care Network Europe (PCNE). The PCNE classification V8.02. http://www.pcne.org/upload/files/230_PCNE_classification_V8-02.pdf (2018). Accessed 16 Dec 2018.
World Health Organization. Medication Without Harm. http://apps.who.int/iris/bitstream/handle/10665/255263/WHO-HIS-SDS-2017.6-eng.pdf. Accessed 16 Dec 2018.
Lampert ML, Kraehenbuehl S, Hug BL. Drug-related problems: evaluation of a classification system in the daily practice of a Swiss University Hospital. Pharm World Sci. 2008;30(6):768–76.
Rashed AN, Wilton L, Lo CC, Kwong BY, Leung S, Wong IC. Epidemiology and potential risk factors of drug-related problems in Hong Kong pediatric wards. Br J Clin Pharmacol. 2014;77(5):873–9.
National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Taxonomy of Medication Errors. http://www.NCCMERP.org. Accessed 16 Dec 2018.
Schorr SG, Eickhoff C, Feldt S, Hohmann C, Schulz M. Exploring the potential impact of hospital ward-based pharmacy interns on drug safety. Pharmazie. 2014;69:316–20.
Hohmann C, Eickhoff C, Klotz JM, Schulz M, Radziwill R. Development of a classification system for drug-related problems in the hospital setting (APS-Doc) and assessment of the inter-rater reliability. J Clin Pharm Ther. 2012;37(3):276–81.
Taeqtmeyer AB, Kullak-Ublick GA, Widmer N, Falk V, Jetter A. Clinical usefulness of electronic drug-drug interaction checking in the care of cardiovascular surgery inpatients. Cardiology. 2012;123(4):219–22.
Basger BJ, Mole RJ. Application of drug-related problem (DRP) classification systems: a review of the literature. Eur J Clin Pharmacol. 2014;70:799–815.
Mao W, Vu H, Xie Z, Chen W, Tang S. Systematic review on irrational use of medicines in China and Vietnam. PLoS ONE. 2015;10(3):e0117710.
Funding
This work was funded by the Chongqing Health and Family Planning Commission Scientific Research Projects (No. 2018ZDXM014).
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All authors declare that they have no conflict of interests.
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Qu, C., Meng, L., Wang, N. et al. Identify and categorize drug-related problems in hospitalized surgical patients in China. Int J Clin Pharm 41, 13–17 (2019). https://doi.org/10.1007/s11096-018-0777-7
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DOI: https://doi.org/10.1007/s11096-018-0777-7