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To Measure is to Know: A Perspective on the Work of Dr. Margareta Hammarlund-Udenaes

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References

  1. Abbott NJ, Rönnbäck L, Hansson E. Astrocyte–endothelial interactions at the blood–brain barrier. Nat Rev Neurosci [Internet]. Nature Publishing Group; 2006 Jan;7(1):41–53. https://doi.org/10.1038/nrn1824.

  2. Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ. Structure and function of the blood–brain barrier. Neurobiol Dis. Academic Press; 2010 Jan;37(1):13–25. https://doi.org/10.1016/j.nbd.2009.07.030.

  3. Ekblom M, Gårdmark M, Hammarlund-Udenaes M. Estimation of unbound concentrations of morphine from microdialysate concentrations by use of nonlinear regression analysis in vivo and in vitro during steady state conditions. Life Sci. 1992;51(6):449–60. https://doi.org/10.1016/0024-3205(92)90413-j.

  4. Hammarlund-Udenaes M, Fridén M, Syvänen S, Gupta A. On the rate and extent of drug delivery to the brain. Pharm. Res. 2008 Aug;25(8):1737–50. https://doi.org/10.1007/s11095-007-9502-2.

  5. Hammarlund-Udenaes M. Microdialysis as an Important Technique in Systems Pharmacology—a Historical and Methodological Review. AAPS J. 2017 Sep;19(5):1294–1303. https://doi.org/10.1208/s12248-017-0108-2.

  6. Xie R, Hammarlund-Udenaes M. Blood-brain barrier equilibration of codeine in rats studied with microdialysis. Pharm Res. 1998 Apr;15(4):570–5. https://doi.org/10.1023/a:1011929910782.

  7. Boström E, Simonsson USH, Hammarlund-Udenaes M. In vivo blood-brain barrier transport of oxycodone in the rat: Indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drug Metab Dispos. 2006 Sep;34(9):1624–31. https://doi.org/10.1124/dmd.106.009746.

  8. Boström E, Hammarlund-Udenaes M, Simonsson USH. Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine. Anesthesiology. 2008 Mar;108(3):495–505. https://doi.org/10.1097/ALN.0b013e318164cf9e.

  9. Fridén M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M. In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids. Drug Metab Dispos. 2007 Sep;35(9):1711–9. https://doi.org/10.1124/dmd.107.015222.

  10. Loryan I, Hammarlund-Udenaes M, Syvänen S. Brain distribution of drugs: pharmacokinetic considerations. 2020 Dec 1. https://doi.org/10.1007/164_2020_405.

  11. Kalvass JC, Maurer TS. Influence of nonspecific brain and plasma binding on CNS exposure: Implications for rational drug discovery. Biopharm Drug Dispos. 2002 Nov;23(8):327–38. https://doi.org/10.1002/bdd.325.

  12. Fridén M, Ducrozet F, Middleton B, Antonsson M, Bredberg U, Hammarlund-Udenaes M. Development of a high-throughput brain slice method for studying drug distribution in the central nervous system. Drug Metab Dispos. 2009 Jun;37(6):1226–33. https://doi.org/10.1124/dmd.108.026377.

  13. Fridén M, Bergström F, Wan H, Rehngren M, Ahlin G, Hammarlund-Udenaes M, et al. Measurement of unbound drug exposure in brain: Modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug Metab Dispos. 2011 Mar;39(3):353–62. https://doi.org/10.1124/dmd.110.035998.

  14. Gupta A, Chatelain P, Massingham R, Jonsson EN, Hammarlund-Udenaes M. Brain distribution of cetirizine enantiomers: Comparison of three different tissue-to-plasma partition coefficients: Kp, Kp,u, and Kp,uu. Drug Metab Dispos. 2006 Feb;34(2):318–23. https://doi.org/10.1124/dmd.105.007211.

  15. de Lange ECM, Hammarlund-Udenaes M. Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients. Clin. Pharmacol. Ther. 2015 Apr;97(4):380–94. https://doi.org/10.1002/cpt.76.

  16. Wong SL, Wang Y, Sawchuk RJ. Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using Microdialysis. Pharm Res An Off J Am Assoc Pharm Sci. 1992 Mar;9(3):332–8. https://doi.org/10.1023/a:1015834701136.

  17. Wang Y, Wong SL, Sawchuk RJ. Microdialysis calibration using retrodialysis and zero-net flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus. Pharm Res An Off J Am Assoc Pharm Sci. 1993 Oct;10(10):1411–9. https://doi.org/10.1023/a:1018906821725.

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Acknowledgements

The authours would like to acknowledge Dr. Hammarlund-Udenaes for her valuable input towards the preparation of this mansucript.

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Authors and Affiliations

  1. Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota Twin Cities, 308 Harvard St SE, Minneapolis, Minnesota, 55455, USA

    Jessica I. Griffith & William F. Elmquist

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  1. Jessica I. Griffith
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  2. William F. Elmquist
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Correspondence to Jessica I. Griffith.

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Griffith, J.I., Elmquist, W.F. To Measure is to Know: A Perspective on the Work of Dr. Margareta Hammarlund-Udenaes. Pharm Res 39, 1297–1301 (2022). https://doi.org/10.1007/s11095-022-03225-x

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