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Anti-Methicillin-Resistant S. aureus Activity of Fruiting Body and Mycelial Culture Extracts of Xylaria longipes Nitschke (Ascomycota)

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Pharmaceutical Chemistry Journal Aims and scope

Resistance to penicillin by Staphylococcus aureus gave rise to methicillin-resistant S. aureus (MRSA) and the emergence of vancomycin-resistant S. aureus (VRSA) that was reported later. Finding an alternative antimicrobial in the treatment of Staphylococcal infections is the need of the hour. In this context, secondary metabolites of both the fruiting body and mycelia of wood-rotting fungi Xylaria longipes were evaluated for anti-MRSA activity. Thin layer chromatographic (TLC) separation and bioautography of the acetone extract revealed a strong anti-MRSA activity at Rf = 0.69 ± 0.28. The bioactive anti-MRSA compound was partially characterized by Fourier transform infrared (FTIR) spectroscopy and liquid chromatography—tandem mass spectrometry (LC-MS/MS). The analysis suggested anti-MRSA activity could be due to integric acid, eremoxylarin C, or a related compound.

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Authors and Affiliations

  1. Department of Microbiology, Yenepoya Medical College, Yenepoya (Deemed-to-be University), University Road, Deralakatte, Mangalore, Karnataka, 575018, India

    K. K. Keekan

  2. Yeneopoya Research Centre, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore, Karnataka, 575018, India

    K. K. Keekan

  3. Talam Biotech Limited, UCD Research and Innovation, NovaUCD, Belfield Innovation Park, University College Dublin, Stillorgan Road, Dublin 4, D04 V2P1, Ireland

    K. K. Keekan

  4. Department of Botany, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar, Hadapsar, Pune, Maharashtra, 411028, India

    K. R. Ranadive

  5. Department of Biosciences, Mangalore University, Mangalagangothri, Karnataka, 574199, India

    P. Naik

  6. Institute of Pharmaceutical Biology and Phytochemistry, University of Muenster, Correnstrasse 48, 48149, Münster, Germany

    J. Sendker

  7. Department of Microbiology, Pushpagiri Institute of Medical Sciences and Research Centre Thiruvalla, Kerala, 689101, India

    S. R. Padmaraj

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Keekan, K.K., Ranadive, K.R., Naik, P. et al. Anti-Methicillin-Resistant S. aureus Activity of Fruiting Body and Mycelial Culture Extracts of Xylaria longipes Nitschke (Ascomycota). Pharm Chem J 56, 958–965 (2022). https://doi.org/10.1007/s11094-022-02733-9

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  • DOI: https://doi.org/10.1007/s11094-022-02733-9

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