Skip to main content
SpringerLink
Log in

Study of Novel Platelet Lysate Film-Forming Spray on Burn Wounds in Rats

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

An Author Correction to this article was published on 16 August 2022

This article has been updated

This study was conducted to investigate the repair effect and mechanism of new platelet lysate film-forming spray (NPLFS) on rat skin burn wound model with a commonly used clinical dressing as the control. Forty-five SD rats were randomly divided into groups, including NPLFS treated (group A, n = 15), platelet-rich plasma (PRP) plaster group (group B, n = 15), and saline gauze cover group (group C, n = 15), fixed with 3M Tegaderm transparent film dressing. The healing rates on the 5th, 10th, 15th and 20th day, the histological hematoxylin and eosin (HE) staining changes on the 10th and 20th day, and the expression of CD31 on the 7th and 21th day after injury were observed. On the day 15 of treatment, the wounds in groups A and B were significantly reduced, while the degree of reduction in group C was not significant. On the day 20 of treatment, the wounds in groups A and B were completely healed and appeared flat, while the wounds in group C were only partly healed. On day 10, the HE staining showed significant increase in neovascularization in groups A and B as compared to group C (n = 3). The CD31 expression on day 20 after treatment showed that the integrated option densities (IODs) for rats in group A (20.13 ± 1.50) and group B (21.15 ± 0.79) were significantly higher than in group C (15.39 ± 1.41, P < 0.01). Therefore, NPLFS can promote the healing of burn wounds, and the effect is similar to that of PRP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Change history

References

  1. C. K. Murray, S. A. Roop, D. R. Hospenthal, et al., Mil. Med., 171, 826 – 829 (2006).

    Article  Google Scholar 

  2. N. E. Aronson, J. W. Sandere, and K. A. Moran, Clin. Infect. Dis., 43, 1045 – 1051 (2006).

    Article  Google Scholar 

  3. D. G. Klein, D. E. Fritsch, S. G. Amin, Crit. Care Nurs. Clin. North. Am., 7(4), 627 – 642 (1995).

    Article  CAS  Google Scholar 

  4. L. Ovington, Ostomy / Wound Management, 49(7), 8 – 12 (2003).

    PubMed  Google Scholar 

  5. J.Wang and L. M. Chen, Funct. Mater. Sci., 44(9), 1294 – 1297 (2013).

    CAS  Google Scholar 

  6. R. Singh and D. Singh, J. Mater. Sci. Mater. Med., 23(11), 2649 – 2658 (2012).

    Article  CAS  Google Scholar 

  7. J. Zhao, Development of PLA / PCL-Chitosan / Gelatin Composite Medical Dressing, Dongju University (2013).

  8. C. Tan and H. Shichinohe, Stem Cells Intern., 6104780 (2016).

  9. P. S. Babo, X. Cai, A. S. Plachokova, et al., Tissue Engin. Part A, 22, 1164 – 1175 (2016).

    Article  CAS  Google Scholar 

  10. J. Beattie, H. Al-Khataji, P. R. Noer, et al., Front. Endocrinol., 9, 510 (2018).

    Article  Google Scholar 

  11. Z. W. Yu, Y. Liang, and W. Q. Liang, Acta Pharm. Sinica, 48(5), 746 – 751 (2013).

    Google Scholar 

  12. C. J. Wang, N. Gu, Y. F. Sun, et al., Southeast Nat. Def. Med., 15(6), 577 – 580 (2013).

    CAS  Google Scholar 

  13. Y. B. Xu, G. Y. Liu, and L. Y. Shi, Chin. J. Blood Trans., 32(11), 1102 – 1105 (2019).

    CAS  Google Scholar 

  14. S. Shanbhag, A. Stavropoulos, S. Suliman, et al., Tissue Eng. Part B: Rev., 23(6), 552–569 (2017).

    Article  CAS  Google Scholar 

  15. G. Y. Liu, G. Q. Shan, Y. N. Zhang, et al., Chin. J. Blood Trans., 27(2), 139 – 142 (2014).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Blood Trafusion, General Hospital of Southern Theater Command, Guangzhou, 510010, China

    Yubing Xu, Guangya Liu, Zhanhong Zhu, Yu Zhang, Mou Zhou, Wei Zhang & Guiqiu Shan

Authors
  1. Yubing Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Guangya Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhanhong Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mou Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Guiqiu Shan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yubing Xu.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, Y., Liu, G., Zhu, Z. et al. Study of Novel Platelet Lysate Film-Forming Spray on Burn Wounds in Rats. Pharm Chem J 56, 446–450 (2022). https://doi.org/10.1007/s11094-022-02657-4

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-022-02657-4

Keywords

Search

Navigation