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Synthesis, Antibacterial and Anticancer Activity of 1,2-Substituted 2,3-Dihydro-1H-Benzo[4,5]Imidazo[1,2-c][1,3,2]Diazaphosphol-1-Oxides

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Pharmaceutical Chemistry Journal Aims and scope

A series of new 1,2-substituted 2,3-dihydro-1H-benzo[4,5]imidazo[1,2-c][1,3,2]diazaphosphol-1-oxides (5a – 5j) were synthesized and characterized by IR and NMR (1H, 13C, and 31P) spectral analysis. The resulting compounds were studied for their antibacterial and antiproliferative activity. Compounds 5f, 5c and 5g showed significantly higher antibacterial activity against both E. Coli and B. Subtilis compared to other compounds. Similarly, MTT assay using THP-I cells showed that all these compounds had significant antiproliferative activity compared to the solvent control, with compounds 5i, 5g and 5c showing more potency than others. The obtained results suggest that compounds 5a – 5j can have a wide variety of pharmaceutical applications.

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Acknowledgments

One of the authors, Dr. M. R. Ganesh, thanks DBT India for support (BT/PR9930/NDB/39/457/2013).

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Authors and Affiliations

  1. Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India

    V. Sankar

  2. Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India

    Vinnie Cheeran & M. R. Ganesh

  3. Department of Chemistry, SRM University AP-Amaravati, Guntur, Andhra Pradesh, 522502, India

    B. Sivakumar

Authors
  1. V. Sankar
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  2. Vinnie Cheeran
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  3. M. R. Ganesh
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  4. B. Sivakumar
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Correspondence to B. Sivakumar.

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Sankar, V., Cheeran, V., Ganesh, M.R. et al. Synthesis, Antibacterial and Anticancer Activity of 1,2-Substituted 2,3-Dihydro-1H-Benzo[4,5]Imidazo[1,2-c][1,3,2]Diazaphosphol-1-Oxides. Pharm Chem J 54, 827–833 (2020). https://doi.org/10.1007/s11094-020-02282-z

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  • DOI: https://doi.org/10.1007/s11094-020-02282-z

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