A conjugate of glycyrrhizic acid (GA) with L-phenylalanine methyl ester was synthesized using N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. Chemical modification of GA via addition of L-phenylalanine methyl ester moieties in the carbohydrate part of the glycoside was shown to form a marginally toxic compound with high anti-inflammatory activity in carrageenan- and formalin-induced mouse inflammation models and with pronounced antiulcer activity in rats. This was a significant advantage of this compound over known anti-inflammatory drugs.
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The work was performed on State Task Topic AAAA-A20-120012090029-0.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 3, pp. 16 – 19, March, 2020.
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Baltina, L.A., Sapozhnikova, T.A., Gabdrakhmanova, S.F. et al. Synthesis and Anti-Inflammatory and Antiulcer Activity of a Glycyrrhizic Acid Conjugate with L-Phenylalanine Methyl Ester. Pharm Chem J 54, 225–228 (2020). https://doi.org/10.1007/s11094-020-02184-0
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DOI: https://doi.org/10.1007/s11094-020-02184-0